Výsledky vyhledávání - "Angelica K. Gierut"

Akademický článek

Nonclassical Ly6C− Monocytes Drive the Development of Inflammatory Arthritis in Mice

Autor: Alexander V. Misharin, Carla M. Cuda, Rana Saber, Jason D. Turner, Angelica K. Gierut, G. Kenneth Haines III, Sergejs Berdnikovs, Andrew Filer, Andrew R. Clark, Christopher D. Buckley, Gökhan M. Mutlu, G.R. Scott Budinger, Harris Perlman

Publikováno v: Cell Reports, Vol 9, Iss 2, Pp 591-604 (2014)

Different subsets and/or polarized phenotypes of monocytes and macrophages may play distinct roles during the development and resolution of inflammation. Here, we demonstrate in a murine model of rheumatoid arthritis that nonclassical Ly6C− monocyt

Externí odkaz: https://doaj.org/article/5f76a3ed4772478ea981cc4cf21d01b1

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Innate Immunity and Rheumatoid Arthritis

Autor: Harris Perlman, Angelica K. Gierut, Richard M. Pope

Publikováno v: Rheumatic Disease Clinics of North America. 36:271-296

Innate immunity, with macrophages playing a central role, is critically important in the pathogenesis of RA. Although environmental insults such as smoking have been implicated in the initiation of rheumatoid arthritis (RA) in patients who express th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372be8a2579269432c82b97b4bcc42a4
https://doi.org/10.1016/j.rdc.2010.03.004

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Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation

Autor: Rana Saber, G. R. Scott Budinger, Harris Perlman, Chandra Mohan, Carla M. Cuda, Jack Hutcheson, Christian Stehlik, Alexander V. Misharin, Stephen M. Hedrick, G. Kenneth Haines, Angelica K. Gierut

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 192(12)

Caspase-8, an executioner enzyme in the death receptor pathway, was shown to initiate apoptosis and suppress necroptosis. In this study, we identify a novel, cell death–independent role for caspase-8 in dendritic cells (DCs): DC-specific expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86dc574648fc4357c8e2b65f53b98c5b
https://pubmed.ncbi.nlm.nih.gov/24808358

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Autor: José Biller, Angelica K. Gierut, Amre Nouh, Ewa Borys

Publikováno v: Frontiers in Neurology, Vol 5 (2014)
Frontiers in Neurology

Amyloid-beta related angiitis (ABRA) of the central nervous system (CNS) is a rare disorder with overlapping features of primary angiits of the CNS (PACNS) and cerebral amyloid angiopathy (CAA). We evaluated a 74-year-old man with intermittent left s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d588a6e6a1e99992c802ffa2f9a3db8d
http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00013/full

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Development of a new humanized mouse model to study acute inflammatory arthritis

Autor: Richard S. Hotchkiss, Angelica K. Gierut, Harris Perlman, G. Kenneth Haines, Alexander V. Misharin, Shawn Rose

Publikováno v: Journal of Translational Medicine
Journal of Translational Medicine, Vol 10, Iss 1, p 190 (2012)

Background Substantial advances have been generated in understanding the pathogenesis of rheumatoid arthritis (RA). Current murine models of RA-like disease have provided great insights into the molecular mechanism of inflammatory arthritis due to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3933dd0b3de1f1207481cba1c43276c1
https://doi.org/10.1186/1479-5876-10-190

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Cyclin-dependent kinase inhibitor p21, via its C-terminal domain, is essential for resolution of murine inflammatory arthritis

Autor: Angelica K. Gierut, Dimitrios Balomenos, Hemant Agrawal, Harris Perlman, G. Kenneth Haines, Deborah V. Novack, Evan W. Weber, Alexander V. Misharin, Carla M. Cuda, Melissa Mavers

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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OBJECTIVE: The mechanism responsible for persistent synovial inflammation in rheumatoid arthritis (RA) is unknown. Previously, we demonstrated that expression of the cyclin-dependent kinase inhibitor p21 is reduced in synovial tissue from RA patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9054ba2be43b857433152516070b2e89
https://pubmed.ncbi.nlm.nih.gov/21898359

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