Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Angelica Benavides-Serrato"'
Autor:
Brent Holmes, Angelica Benavides-Serrato, Jacquelyn T. Saunders, Sunil Kumar, Robert N. Nishimura, Joseph Gera
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 9, Pp 951-965 (2021)
The Hippo and mTOR signaling cascades are major regulators of cell growth and division. Aberrant regulation of these pathways has been demonstrated to contribute to gliomagenesis and result in enhanced glioblastoma proliferation and invasive characte
Externí odkaz:
https://doaj.org/article/b01e8986ccf741549a1fff9a968ce1fb
Autor:
Angelica Benavides-Serrato, Jihye Lee, Brent Holmes, Kenna A Landon, Tariq Bashir, Michael E Jung, Alan Lichtenstein, Joseph Gera
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212160 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0176599.].
Externí odkaz:
https://doaj.org/article/6135fc6ac3384c2cb1bc61b7bb8498c8
Autor:
Angelica Benavides-Serrato, Jihye Lee, Brent Holmes, Kenna A Landon, Tariq Bashir, Michael E Jung, Alan Lichtenstein, Joseph Gera
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176599 (2017)
A small molecule which specifically blocks the interaction of Rictor and mTOR was identified utilizing a high-throughput yeast two-hybrid screen and evaluated as a potential inhibitor of mTORC2 activity in glioblastoma multiforme (GBM). In vitro, CID
Externí odkaz:
https://doaj.org/article/dfba5d1f920047d6a7daff473ec6327c
Autor:
Tariq Bashir, Cheri Cloninger, Nicholas Artinian, Lauren Anderson, Andrew Bernath, Brent Holmes, Angelica Benavides-Serrato, Nesrin Sabha, Robert N Nishimura, Abhijit Guha, Joseph Gera
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47741 (2012)
Hyperactivation of the mTORC2 signaling pathway has been shown to contribute to the oncogenic properties of gliomas. Moreover, overexpression of the mTORC2 regulatory subunit Rictor has been associated with increased proliferation and invasive charac
Externí odkaz:
https://doaj.org/article/721fd34cf976430c8349f3a93c63e338
Autor:
Jacquelyn T. Saunders, Sunil Kumar, Angelica Benavides-Serrato, Brent Holmes, Kennedy E. Benavides, Muhammad T. Bashir, Robert N. Nishimura, Joseph Gera
Publikováno v:
Journal of Neuro-Oncology. 163:207-218
Introduction HGF/c-MET signaling is a significant driver of glioblastoma (GBM) growth and disease progression. Unfortunately, c-MET targeted therapies have been found to be largely ineffective suggesting additional redundant mechanisms of c-MET activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af1f1b527e20811fcb6f4bcd6e455df
https://doi.org/10.1007/s11060-023-04331-5
https://doi.org/10.1007/s11060-023-04331-5
Autor:
Sunil Kumar, Robert N. Nishimura, Jacquelyn T Saunders, Angelica Benavides-Serrato, Brent Holmes, Joseph Gera
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 9, Pp 951-965 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
The Hippo and mTOR signaling cascades are major regulators of cell growth and division. Aberrant regulation of these pathways has been demonstrated to contribute to gliomagenesis and result in enhanced glioblastoma proliferation and invasive characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93125b3b9c909d064550cda15a19ad9f
https://doi.org/10.1016/j.neo.2021.07.005
https://doi.org/10.1016/j.neo.2021.07.005
Autor:
Angelica Benavides-Serrato, Jacquelyn T. Saunders, Sunil Kumar, Brent Holmes, Kennedy E. Benavides, Muhammad T. Bashir, Robert N. Nishimura, Joseph Gera
Publikováno v:
Cancer Letters. 562:216178
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db70e0ae294e800283f2b8fe19eb2237
https://doi.org/10.1016/j.canlet.2023.216178
https://doi.org/10.1016/j.canlet.2023.216178
Autor:
Sunil Kumar, Jacquelyn T Saunders, Angelica Benavides-Serrato, Brent Holmes, Joseph Gera, Robert N. Nishimura
Publikováno v:
J Neurooncol
INTRODUCTION: Recent studies have suggested that dysregulated Hippo pathway signaling may contribute to glioblastoma proliferation and invasive characteristics. The downstream effector of the pathway, the Yes-associated protein (YAP) oncoprotein, has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc6760bfbaf4c5571c9977c3531abf2
https://doi.org/10.1007/s11060-021-03699-6
https://doi.org/10.1007/s11060-021-03699-6
Autor:
Joseph Gera, Adam J Schreck, Angelica Benavides-Serrato, Kenna A. Landon, Brent Holmes, Jacquelyn T Saunders, Robert N. Nishimura
Publikováno v:
J Neurooncol
INTRODUCTION: Clinical trials directed at mechanistic target of rapamycin (mTOR) inhibition have yielded disappointing results in glioblastoma (GBM). A major mechanism of resistance involves the activation of a salvage pathway stimulating internal ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8169220e6a6ddb15c4dde224d2feea58
https://doi.org/10.1007/s11060-019-03274-0
https://doi.org/10.1007/s11060-019-03274-0
Autor:
Jacquelyn T Saunders, Alan Lichtenstein, Brent Holmes, Robert N. Nishimura, Angelica Benavides-Serrato, Joseph Gera
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 1
International Journal of Molecular Sciences, Vol 21, Iss 1, p 344 (2020)
Volume 21
Issue 1
International Journal of Molecular Sciences, Vol 21, Iss 1, p 344 (2020)
Internal ribosome entry site (IRES)-mediated protein synthesis has been demonstrated to play an important role in resistance to mechanistic target of rapamycin (mTOR) targeted therapies. Previously, we have demonstrated that the IRES trans-acting fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca042568c98ca76a9f1b40dfbc01751