Red Blood Cell-Derived Iron Alters Macrophage Function in COPD

Autor: James M. Baker, Molly Hammond, Josiah Dungwa, Rajesh Shah, Angeles Montero-Fernandez, Andrew Higham, Simon Lea, Dave Singh

Publikováno v: Biomedicines, Vol 9, Iss 12, p 1939 (2021)

Lung macrophage iron levels are increased in COPD patients. Lung macrophage iron levels are thought to be increased by cigarette smoke, but the role of red blood cells (RBCs) as a source of iron has not been investigated. We investigate RBCs as a pot

Externí odkaz: https://doaj.org/article/9a715e801c01449398825a4069b3d002

Histopathology features of the lung in COVID-19 patients

Autor: Angeles Montero-Fernandez, M., Pardo-Garcia, Ricardo

Publikováno v: In Diagnostic Histopathology March 2021 27(3):123-127

Renal hemofiltration prevents metabolic acidosis and reduces inflammation during normothermic machine perfusion of the vascularized composite allograft—A preclinical study

Autor: James E. Fildes, John P Stone, Jason Wong, Timothy R Entwistle, Jak Kerr, Matthew Shaw, Dilan Dabare, Kavit Amin, Angeles Montero-Fernandez, Abbey Geraghty, David Brough

Publikováno v: Stone, JP, Amin, KR, Geraghty, A, Kerr, J, Shaw, M, Dabare, D, Wong, JK, Brough, D, Entwistle, TR, Montero-Fernandez, A & Fildes, JE 2022, ' Renal hemofiltration prevents metabolic acidosis and reduces inflammation during normothermic machine perfusion of the vascularized composite allograft—A preclinical study ', Artificial Organs, vol. 46, no. 2, pp. 259-272 . https://doi.org/10.1111/aor.14089

Introduction: Recent experimental evidence suggests normothermic machine perfusion of the vascularized composite allograft results in improved preservation compared to static cold storage, with less reperfusion injury in the immediate post-operative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afee957e588839d4433b6220aa3fee2
https://doi.org/10.1111/aor.14089

COPD lung studies of Nrf2 expression and the effects of Nrf2 activators

Autor: Jian Li, James Baker, Andrew Higham, Rajesh Shah, Angeles Montero-Fernandez, Clare Murray, Nicky Cooper, Cathy Lucas, Craig Fox, Dave Singh, Simon Lea

Publikováno v: Li, J, Baker, J, Higham, A, Shah, R, Montero-Fernandez, A, Murray, C, Cooper, N, Lucas, C, Fox, C, Singh, D & Lea, S 2022, ' COPD lung studies of Nrf2 expression and the effects of Nrf2 activators ', Inflammopharmacology, vol. 30, no. 4, pp. 1431-1443 . https://doi.org/10.1007/s10787-022-00967-3

Background Nrf2 regulates cellular antioxidant defence in lung cells, including epithelial cells and alveolar macrophages (AM). The Nrf2/Keap-1 pathway can be modulated by activators with different modes of action; electrophilic compounds and protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ce5cf954210f2573271f88e0e7eba6
https://pubmed.ncbi.nlm.nih.gov/35441963

Histopathology features of the lung in COVID-19 patients

Autor: M. Angeles Montero-Fernandez, Ricardo Pardo-Garcia

Publikováno v: Diagnostic Histopathology (Oxford, England)
Diagnostic Histopathology

COVID-19 is the infectious disease caused by the recently discovered coronavirus, SARS-CoV-2, unknown before the outbreak in Wuhan, China, in December 2019. COVID-19 is a pandemic, infectious disease that has simultaneously affected many countries gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e4819b14a7784de50a0fef6e8dc963
http://europepmc.org/articles/PMC7717771