Molecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gating.

Autor: Jorge Fernández-Trillo, Francisco Barros, Angeles Machín, Luis Carretero, Pedro Domínguez, Pilar de la Peña

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24674 (2011)

A conserved eag domain in the cytoplasmic amino terminus of the human ether-a-go-go-related gene (hERG) potassium channel is critical for its slow deactivation gating. Introduction of gene fragments encoding the eag domain are able to restore normal

Externí odkaz: https://doaj.org/article/0cd719c081424fe2af7881d1474d5fc5

Mapping of interactions between the N- and C-termini and the channel core in HERG K+ channels

Autor: Pedro Domínguez, Francisco Barros, Pilar de la Peña, Jorge Fernández-Trillo, Angeles Machín

Publikováno v: Biochemical Journal. 451:463-474

The characteristic gating properties of the HERG [human eag (ether-a-go-go)-related gene] potassium channel determine its contribution to cardiac repolarization and in setting the electrical behaviour of a variety of cells. In the present study we an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba5120b222fc496bd3fc23a81c1515e
https://doi.org/10.1042/bj20121717

Isolation and characterization of a new Vesivirus from rabbits

Autor: David O. Matson, Alvin W. Smith, José M. Martín-Alonso, Angeles Machín, Nathan K. Keefer, Gloria del Barrio, Patrick L. Iversen, Lorenzo González-Molleda, Douglas E. Skilling, Francisco Parra

Publikováno v: Virology. 337(2):373-383

This report describes the isolation, cDNA cloning, complete genome nucleotide sequence, and partial characterization of a new cultivable calicivirus isolated from juvenile feeder European rabbits (Oryctolagus cuniculus) showing symptoms of diarrhea.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597842396296b20da0542f4ecf3aff3b

Identification of the Amino Acid Residue Involved in Rabbit Hemorrhagic Disease Virus VPg Uridylylation

Autor: José M. Martín Alonso, Francisco Parra, Angeles Machín

Publikováno v: Journal of Biological Chemistry. 276:27787-27792

The virus genome-linked protein (VPg) coding region from rabbit hemorrhagic disease virus (RHDV) (isolate AST/89) was expressed in Escherichia coli by using a glutathione S-transferase-based vector. The recombinant polypeptide could be purified in go

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88582e8543dc816bb83357871e7c2632
https://doi.org/10.1074/jbc.m100707200

Cell type influences the molecular mechanisms involved in hormonal regulation of ERG K+ channels

Autor: Pablo Miranda, Luis Carretero, Jorge Fernández-Trillo, Pilar de la Peña, Angeles Machín, Pedro Domínguez, Francisco Barros

Publikováno v: Scopus
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
RUO. Repositorio Institucional de la Universidad de Oviedo
instname

While the thyrotropin-releasing hormone (TRH) effect of raising intracellular Ca(2+) levels has been shown to rely on G(q/11) and PLC activation, the molecular mechanisms involved in the regulation of ERG K(+) channels by TRH are still partially unkn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a970fef76b42497b7953b4e541edacb0
http://hdl.handle.net/10651/23782