Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Angeles Duran"'
Autor:
Anxo Martinez-Ordoñez, Hiroto Kinoshita, Tania Cid-Diaz, Angeles Duran, Marta Osrodek, Maria T. Diaz-Meco, Jorge Moscat
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103303- (2024)
Summary: Applying Opal multiplex immunofluorescence (OMI) to characterize intestinal tissues of genetically engineered mouse models provides an excellent tool for studying complex processes. However, detecting appropriate signals from multiple target
Externí odkaz:
https://doaj.org/article/a7f238d9bb394ea9b94266059e852c5d
Autor:
Yu Muta, Juan F. Linares, Anxo Martinez-Ordoñez, Angeles Duran, Tania Cid-Diaz, Hiroto Kinoshita, Xiao Zhang, Qixiu Han, Yuki Nakanishi, Naoko Nakanishi, Thekla Cordes, Gurpreet K. Arora, Marc Ruiz-Martinez, Miguel Reina-Campos, Hiroaki Kasashima, Masakazu Yashiro, Kiyoshi Maeda, Ana Albaladejo-Gonzalez, Daniel Torres-Moreno, José García-Solano, Pablo Conesa-Zamora, Giorgio Inghirami, Christian M. Metallo, Timothy F. Osborne, Maria T. Diaz-Meco, Jorge Moscat
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract The metabolic and signaling pathways regulating aggressive mesenchymal colorectal cancer (CRC) initiation and progression through the serrated route are largely unknown. Although relatively well characterized as BRAF mutant cancers, their po
Externí odkaz:
https://doaj.org/article/7936ce2ec8a04c66b79574c289fddb37
Autor:
Mayuki Omatsu, Yuki Nakanishi, Kosuke Iwane, Naoki Aoyama, Angeles Duran, Yu Muta, Anxo Martinez-Ordoñez, Qixiu Han, Nobukazu Agatsuma, Kenta Mizukoshi, Munenori Kawai, Go Yamakawa, Mio Namikawa, Kensuke Hamada, Yuichi Fukunaga, Takahiro Utsumi, Makoto Sono, Tomonori Masuda, Akitaka Hata, Osamu Araki, Munemasa Nagao, Takaaki Yoshikawa, Satoshi Ogawa, Yukiko Hiramatsu, Motoyuki Tsuda, Takahisa Maruno, Toshiaki Kogame, Hiroaki Kasashima, Nobuyuki Kakiuchi, Masahiro M. Nakagawa, Kenji Kawada, Masakazu Yashiro, Kiyoshi Maeda, Yasuyuki Saito, Takashi Matozaki, Akihisa Fukuda, Kenji Kabashima, Kazutaka Obama, Seishi Ogawa, Nader Sheibani, Maria T. Diaz-Meco, Jorge Moscat, Hiroshi Seno
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Mesenchymal activation, characterized by dense stromal infiltration of immune and mesenchymal cells, fuels the aggressiveness of colorectal cancers (CRC), driving progression and metastasis. Targetable molecules in the tumor microenvironment
Externí odkaz:
https://doaj.org/article/faf191500a2f4f9e8f8e32b58ac4ba14
Autor:
Anxo Martinez-Ordoñez, Tania Cid-Diaz, Angeles Duran, Qixiu Han, Jorge Moscat, Maria T. Diaz-Meco
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102243- (2023)
Summary: Imaging organoid culture provides an excellent tool for studying complex diseases such as cancer. However, retaining the morphology of intact organoids for immunolabeling has been challenging. Here, we describe a protocol for immunofluoresce
Externí odkaz:
https://doaj.org/article/12e40ca87e424f45b1641e5dd9553d85
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101635- (2022)
Summary: Air-liquid organotypic culture models enable the study of the cellular crosstalk in the tumor microenvironment. This 3D assay recapitulates the tumor niche more faithfully than 2D culture systems and represents a versatile platform that can
Externí odkaz:
https://doaj.org/article/2f1b844e394e4772baeb0915e5d617a5
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ
Autor:
Jianfeng Huang, Juan F. Linares, Angeles Duran, Wenmin Xia, Alan R. Saltiel, Timo D. Müller, Maria T. Diaz-Meco, Jorge Moscat
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
p62 is a signaling hub protein that contributes to the control of energy expenditure. Here the authors investigate the relative roles of p62 and a similar protein, NBR1, and show that NBR1 is required for the repression of thermogenesis in adipocytes
Externí odkaz:
https://doaj.org/article/1f44af61cd1540b195d9f442e64e2d81
Autor:
Hiroaki Kasashima, Angeles Duran, Tania Cid-Diaz, Yu Muta, Hiroto Kinoshita, Eduard Batlle, Maria T. Diaz-Meco, Jorge Moscat
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100297- (2021)
Summary: In vivo interrogation of the functional role of genes implicated in colorectal cancer (CRC) is limited by the need for physiological models that mimic the disease. Here, we describe a protocol that provides the steps required for the orthoto
Externí odkaz:
https://doaj.org/article/74501688acdc46989f1bbf4596c7544d
Autor:
Hiroaki Kasashima, Angeles Duran, Tania Cid-Diaz, Yotaro Kudo, Maria T. Diaz-Meco, Jorge Moscat
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100185- (2020)
Summary: This protocol provides the steps required for a mouse liver orthotopic implantation model. The reliable pre-clinical animal models that have similar characteristics to hepatocellular carcinoma (HCC) are a powerful tool to unveil the mechanis
Externí odkaz:
https://doaj.org/article/2e80bf2ebd594560aaadb1533afd5ce5
Autor:
Phillip M. Shelton, Angeles Duran, Yuki Nakanishi, Miguel Reina-Campos, Hiroaki Kasashima, Victoria Llado, Li Ma, Alex Campos, Damián García-Olmo, Mariano García-Arranz, Dolores C. García-Olmo, Susana Olmedillas-López, Javier F. Caceres, Maria T. Diaz-Meco, Jorge Moscat
Publikováno v:
Cell Reports, Vol 23, Iss 4, Pp 1178-1191 (2018)
Summary: Most colorectal cancer (CRC)-related deaths are due to liver metastases. PKCζ is a tumor suppressor in CRC with reduced expression in metastasis. Given the importance of microRNAs (miRNAs) in regulating cellular plasticity, we performed an
Externí odkaz:
https://doaj.org/article/90339dc9bd2348feb85281d308cdb24b
Autor:
Juan F. Linares, Angeles Duran, Miguel Reina-Campos, Pedro Aza-Blanc, Alex Campos, Jorge Moscat, Maria T. Diaz-Meco
Publikováno v:
Cell Reports, Vol 12, Iss 8, Pp 1339-1352 (2015)
The mTORC1 complex is central to the cellular response to changes in nutrient availability. The signaling adaptor p62 contributes to mTORC1 activation in response to amino acids and interacts with TRAF6, which is required for the translocation of mTO
Externí odkaz:
https://doaj.org/article/2c6d5ee8e18143f5916dabd65e713201