Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Angeles, Almeida"'
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106199- (2023)
Mitochondrial reactive oxygen species (mROS) have been generally considered harmful byproducts wanted to clear when elevated to avoid brain damage. However, the abundance of mROS in astrocytes is very high -about one order of magnitude above that in
Externí odkaz:
https://doaj.org/article/7979a4cd33634a7493036d1f1d216732
Autor:
Irene Lopez-Fabuel, Marina Garcia-Macia, Costantina Buondelmonte, Olga Burmistrova, Nicolo Bonora, Paula Alonso-Batan, Brenda Morant-Ferrando, Carlos Vicente-Gutierrez, Daniel Jimenez-Blasco, Ruben Quintana-Cabrera, Emilio Fernandez, Jordi Llop, Pedro Ramos-Cabrer, Aseel Sharaireh, Marta Guevara-Ferrer, Lorna Fitzpatrick, Christopher D. Thompton, Tristan R. McKay, Stephan Storch, Diego L. Medina, Sara E. Mole, Peter O. Fedichev, Angeles Almeida, Juan P. Bolaños
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
CLN7 neuronal ceroid lipofuscinosis is an inherited lysosomal storage disease typically with childhood onset of neurodegenerative symptoms. Here the authors report that in a mouse model of CLN7 disease neuronal reactive oxygen species and the activit
Externí odkaz:
https://doaj.org/article/3a651b3190b84e729467d309cc661713
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and the main cause of dementia in the elderly. The disease has a high impact on individuals and their families and represents a growing public health and socio-economic burde
Externí odkaz:
https://doaj.org/article/cd0fc783b14746169b3ba149b08515af
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, which is causally related to the accumulation of abnormally folded amyloid-β (Aβ) peptide and hyperphosphorylated tau protein aggregates. The
Externí odkaz:
https://doaj.org/article/78252a68aa4d45fab935ec7ff38e59c5
Autor:
Olga Burmistrova, Ana Olias-Arjona, Rebeca Lapresa, Daniel Jimenez-Blasco, Tatiana Eremeeva, Dmitry Shishov, Sergei Romanov, Kristina Zakurdaeva, Angeles Almeida, Peter O. Fedichev, Juan P. Bolaños
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract The glycolytic rate in neurons is low in order to allow glucose to be metabolized through the pentose-phosphate pathway (PPP), which regenerates NADPH to preserve the glutathione redox status and survival. This is controlled by 6-phosphofruc
Externí odkaz:
https://doaj.org/article/883ca8c766f94de9a52ed1902af7bd39
Publikováno v:
Essays in Biochemistry. 67:17-26
Astrocytes show unique anatomical, morphological, and metabolic features to take up substrates from the blood and metabolize them for local delivery to active synapses to sustain neuron function. In the present review, we specifically focus on key mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22ff41510874a5d2dc25d258673135e3
https://doi.org/10.1042/ebc20220075
https://doi.org/10.1042/ebc20220075
Autor:
Carlos Vicente-Gutierrez, Nicolo Bonora, Daniel Jimenez-Blasco, Irene Lopez-Fabuel, Georgina Bates, Michael P. Murphy, Angeles Almeida, Juan P. Bolaños
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101917- (2021)
Cells naturally produce mitochondrial reactive oxygen species (mROS), but the in vivo pathophysiological significance has long remained controversial. Within the brain, astrocyte-derived mROS physiologically regulate behaviour and are produced at one
Externí odkaz:
https://doaj.org/article/9462a7ade17b47cc88f555f221fcda57
Autor:
Seila Fernandez-Fernandez, Veronica Bobo-Jimenez, Raquel Requejo-Aguilar, Silvia Gonzalez-Fernandez, Monica Resch, Monica Carabias-Carrasco, Joaquim Ros, Angeles Almeida, Juan P. Bolaños
Publikováno v:
Redox Biology, Vol 19, Iss , Pp 52-61 (2018)
Loss of brain glutathione has been associated with cognitive decline and neuronal death during aging and neurodegenerative diseases. However, whether decreased glutathione precedes or follows neuronal dysfunction has not been unambiguously elucidated
Externí odkaz:
https://doaj.org/article/1a2bfe24eb2e4c2aa575d43ec958f2d2
Autor:
Rebeca Vecino, Maria C. Burguete, Teresa Jover-Mengual, Jesus Agulla, Verónica Bobo-Jiménez, Juan B. Salom, Angeles Almeida, Maria Delgado-Esteban
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Brain preconditioning (PC) refers to a state of transient tolerance against a lethal insult that can be evoked by a prior mild event. It is thought that PC may induce different pathways responsible for neuroprotection, which may involve the
Externí odkaz:
https://doaj.org/article/7d5f510a33134e7a88cb679243ce66fa
Autor:
Emilia Barrio, Rebeca Vecino, Irene Sánchez-Morán, Cristina Rodríguez, Alberto Suárez-Pindado, Juan P. Bolaños, Angeles Almeida, Maria Delgado-Esteban
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7275 (2021)
One of the most important mechanisms of preconditioning-mediated neuroprotection is the attenuation of cell apoptosis, inducing brain tolerance after a subsequent injurious ischemia. In this context, the antiapoptotic PI3K/AKT signaling pathway plays
Externí odkaz:
https://doaj.org/article/c9b5088967254056821d1f18654a7825