Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Angela Zacher"'
Autor:
Michael Weller, Guido Reifenberger, Markus Loeffler, Andreas von Deimling, Torsten Pietsch, Jörg C. Tonn, Gabriele Schackert, Manfred Westphal, Matthias Simon, Michael Sabel, Marcel Kamp, Bastian Malzkorn, Angela Zacher, Dorothee Gramatzki, Kerstin Kaulich, Bettina Hentschel, Jörg Felsberg
Supplementary Table 1. Overview of the individual survival times, MGMT promoter methylation status and results of EGFRvIII testing by immunohistochemistry (IHC) or reverse transcription-PCR (RT-PCR) in primary tumors (PT) and recurrent tumors (RT) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c21fd55e333de4597b4002762a3d14
https://doi.org/10.1158/1078-0432.22461966.v1
https://doi.org/10.1158/1078-0432.22461966.v1
Autor:
Michael Weller, Guido Reifenberger, Markus Loeffler, Andreas von Deimling, Torsten Pietsch, Jörg C. Tonn, Gabriele Schackert, Manfred Westphal, Matthias Simon, Michael Sabel, Marcel Kamp, Bastian Malzkorn, Angela Zacher, Dorothee Gramatzki, Kerstin Kaulich, Bettina Hentschel, Jörg Felsberg
Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about half of these tumors express the EGFRvIII variant. The prognostic role of EGFRvIII in EGFR-amplified glioblastoma patients and changes in EGFRvIII expression in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428b8d7395b86f3e04f80ef213f5d298
https://doi.org/10.1158/1078-0432.c.6524967.v1
https://doi.org/10.1158/1078-0432.c.6524967.v1
Autor:
Caroline von Achenbach, Doriano Fabbro, Dorothee Gramatzki, Emese Szabo, Kerstin Kaulich, Guido Reifenberger, Angela Zacher, Michael Weller
Molecular genetic aberrations in the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway are common in human cancers including glioblastoma, yet, novel therapeutic approaches targeting this pathway in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85694ec50ab80a4520c104351486aba6
https://www.zora.uzh.ch/id/eprint/176282/
https://www.zora.uzh.ch/id/eprint/176282/
Autor:
Dorothee Gramatzki, Doriano Fabbro, G. Reifenberger, Michael Weller, Angela Zacher, Kerstin Kaulich, Emese Szabo, C von Achenbach
Publikováno v:
Neuro Oncol
BACKGROUND Molecular genetic aberrations in the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway are common in human cancers including glioblastoma, yet, novel therapeutic approaches targeting this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f3f598c375ce966aabb140a62a1957
https://europepmc.org/articles/PMC6796173/
https://europepmc.org/articles/PMC6796173/
Autor:
Stefanie Stepanow, Jörg Felsberg, Marietta Wolter, Guido Reifenberger, Angela Zacher, Karl Köhrer, Kerstin Kaulich, Bastian Malzkorn
Publikováno v:
Brain Pathology. 27:146-159
Current classification of gliomas is based on histological criteria according to the World Health Organization (WHO) classification of tumors of the central nervous system. Over the past years, characteristic genetic profiles have been identified in
Autor:
Verena, Körber, Jing, Yang, Pankaj, Barah, Yonghe, Wu, Damian, Stichel, Zuguang, Gu, Michael Nai Chung, Fletcher, David, Jones, Bettina, Hentschel, Katrin, Lamszus, Jörg Christian, Tonn, Gabriele, Schackert, Michael, Sabel, Jörg, Felsberg, Angela, Zacher, Kerstin, Kaulich, Daniel, Hübschmann, Christel, Herold-Mende, Andreas, von Deimling, Michael, Weller, Bernhard, Radlwimmer, Matthias, Schlesner, Guido, Reifenberger, Thomas, Höfer, Peter, Lichter
Publikováno v:
Cancer cell. 35(4)
We studied how intratumoral genetic heterogeneity shapes tumor growth and therapy response for isocitrate dehydrogenase (IDH)-wild-type glioblastoma, a rapidly regrowing tumor. We inferred the evolutionary trajectories of matched pairs of primary and
Autor:
Gustavo B. Baretton, J. Sperveslage, Falko Fend, Wilko Weichert, Thomas Mayr, Sven Weidner, S. Lerke, Burkhard Hirsch, Karl Köhrer, Martin-Leo Hansmann, Stefanie Stepanow, Silke Lassmann, Peter Schirmacher, V. Kovaleva, Michael Hummel, Daniela Aust, T. Kirchner, Kerstin Kaulich, Andreas Jung, Guido Reifenberger, Angela Zacher, Volker Endris, Manfred Dietel, E. von der Wall, Nicole Pfarr, L. Burbat, Irina Bonzheim, Martin Werner
Publikováno v:
Virchows Archiv
The simultaneous detection of multiple somatic mutations in the context of molecular diagnostics of cancer is frequently performed by means of amplicon-based targeted next-generation sequencing (NGS). However, only few studies are available comparing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aaaad90252e42ca2df1a837cc1b0f0b
https://mediatum.ub.tum.de/doc/1531306/document.pdf
https://mediatum.ub.tum.de/doc/1531306/document.pdf
Autor:
Christiane A. Opitz, Andreas von Deimling, Ahmed Sadik, Michael Weller, Ulrich Sure, Michael Sabel, Michael Platten, Joachim P. Steinbach, Anca L. Grosu, Martin Bendszus, Stefan M. Pfister, Dietmar Krex, Tobias Kessler, Anne Hertenstein, David T.W. Jones, Ghazaleh Tabatabai, Wolfgang Wick, Melanie Bewerunge-Hudler, Damian Stichel, Guido Reifenberger, Angela Zacher, Felix Sahm
BACKGROUND: O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status is a predictive biomarker in glioblastoma. We investigated whether this marker furthermore defines a molecularly distinct tumor subtype with clinically different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485501fc15764106ebd86189b69175a2
https://www.ncbi.nlm.nih.gov/pubmed/29016808
https://www.ncbi.nlm.nih.gov/pubmed/29016808
Autor:
Jörg, Felsberg, Bettina, Hentschel, Kerstin, Kaulich, Dorothee, Gramatzki, Angela, Zacher, Bastian, Malzkorn, Marcel, Kamp, Michael, Sabel, Matthias, Simon, Manfred, Westphal, Gabriele, Schackert, Jörg C, Tonn, Torsten, Pietsch, Andreas, von Deimling, Markus, Loeffler, Guido, Reifenberger, Michael, Weller
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 23(22)
Autor:
Verena Körber, Damian Stichel, Katrin Lamszus, Andreas von Deimling, Christel Herold-Mende, David T.W. Jones, Pankaj Barah, Michael Sabel, Michael N. C. Fletcher, Thomas Höfer, Zuguang Gu, Kerstin Kaulich, Jörg Felsberg, Bettina Hentschel, Guido Reifenberger, Angela Zacher, Jörg C. Tonn, Gabriele Schackert, Daniel Hübschmann, Michael Weller, Jing Yang, Matthias Schlesner, Peter Lichter, Yonghe Wu, Bernhard Radlwimmer
Publikováno v:
Cancer Cell. 35:692-704.e12
We studied how intratumoral genetic heterogeneity shapes tumor growth and therapy response for isocitrate dehydrogenase (IDH)-wild-type glioblastoma, a rapidly regrowing tumor. We inferred the evolutionary trajectories of matched pairs of primary and