Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

Autor: Pau Martin-Malpartida, Marta Batet, Zuzanna Kaczmarska, Regina Freier, Tiago Gomes, Eric Aragón, Yilong Zou, Qiong Wang, Qiaoran Xi, Lidia Ruiz, Angela Vea, José A. Márquez, Joan Massagué, Maria J. Macias

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Smad transcription factors are part of the TGF-β signal transduction pathways and are recruited to the genome by cell lineage-defining factors. Here, the authors identify specific Smad binding GC-rich motifs and provide structural information showin

Externí odkaz: https://doaj.org/article/2fc17c23ddc242eeb5acfe143eb35089

Criteria for referring patients to Spanish Atherosclerosis Society lipid units

Autor: Miguel Ángel Sánchez-Chaparro, Pablo Pérez-Martínez, Diana Ibarretxe, Manuel Suárez-Tembra, Pedro Valdivielso, Emilio Ros, Sergio Martínez, Ana Cenarro, Miguel Ángel Sánchez, Daiana Ibarretxe, Manuel Suárez, Ovidio Muñiz, Pablo Pérez, Agustín Blanco, Angela Vea, Rocio Toro, Enric Serra, Manuel Jesus Romero, Carmen Rodriguez, Anna Pardo, Laura Márquez, Alberto de los Santos, Miguel Ángel Corrales, Assumpta Caixàs, Marta Bueno

Publikováno v: Clínica e Investigación en Arteriosclerosis (English Edition). 31:26-30

The Spanish Arteriosclerosis Society has accredited more than 70 lipid units across the country. The main criteria for patients to be referred to these units are presented. These are not only grouped by the type of dyslipidaemia or the lipid levels,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfec30e341662b06db1b2bba6d2ee203
https://doi.org/10.1016/j.artere.2019.01.002

Circulating non-coding RNAs in biomarker-guided cardiovascular therapy: a novel tool for personalized medicine?

Autor: Carlos Brotons, Liam Couch, Angela Vea, David de Gonzalo-Calvo, Vicenta Llorente-Cortés, Jan Fiedler, Christian Bär, Thomas Thum

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
European Heart Journal

Current clinical guidelines emphasize the unmet need for technological innovations to guide physician decision-making and to transit from conventional care to personalized cardiovascular medicine. Biomarker-guided cardiovascular therapy represents an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a467db29d60e0d194651d71eba03face
https://doi.org/10.1093/eurheartj/ehy234

Plasma microRNA profiling reveals novel biomarkers of epicardial adipose tissue: A multidetector computed tomography study

Autor: Sonia Benitez, David Vilades, Angela Vea, Andreu Ferrero-Gregori, Vicenta Llorente-Cortés, Francesc Carreras, Jesus Sanchez Vega, David de Gonzalo-Calvo, Pablo Martínez-Camblor, Laura Nasarre, Olga Bornachea, José Luis Sánchez-Quesada, Núria Puig, Rubén Leta

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Clinical Medicine, Vol 8, Iss 6, p 780 (2019)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Journal of Clinical Medicine
Volume 8
Issue 6

Epicardial adipose tissue (EAT) constitutes a novel parameter for cardiometabolic risk assessment and a target for therapy. Here, we evaluated for the first time the plasma microRNA (miRNA) profile as a source of biomarkers for epicardial fat volume

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abaeba85edd7c61c2ec0302e46145081
http://hdl.handle.net/10261/185043

Molecular basis for the protective effects of low-density lipoprotein receptor-related protein 1 (LRP1)-derived peptides against LDL aggregation

Autor: Aleyda Benitez-Amaro, Olga Bornachea, Teresa Tarragó, Vicenta Llorente-Cortés, Cristina Chiva, Sonia Benitez, Roger Prades, Sandra Villegas, José Luis Sánchez-Quesada, Andrea Rivas-Urbina, David de Gonzalo-Calvo, Eduard Sabidó, Laura Nasarre, Gabriel Serra-Mir, Chiara Pallara, Angela Vea

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau

Aggregated LDL is the first ligand reported to interact with the cluster II CR9 domain of low-density lipoprotein receptor-related protein 1 (LRP1). In particular, the C-terminal half of domain CR9, comprising the region Gly1127-Cys1140 exclusively r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85f15b30f5386c57ce4d6ebebe38ec5
http://hdl.handle.net/10261/201668