Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Angela Tramonti"'
Autor:
Eleonora Pilesi, Giulia Tesoriere, Angelo Ferriero, Elisa Mascolo, Francesco Liguori, Luca Argirò, Chiara Angioli, Angela Tramonti, Roberto Contestabile, Cinzia Volontè, Fiammetta Vernì
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-13 (2024)
Abstract Vitamin B6 is a water-soluble vitamin which possesses antioxidant properties. Its catalytically active form, pyridoxal 5’-phosphate (PLP), is a crucial cofactor for DNA and amino acid metabolism. The inverse correlation between vitamin B6
Externí odkaz:
https://doaj.org/article/fa51980441b04013bdda26692f01a735
Autor:
Marco Malatesta, Emanuele Fornasier, Martino Luigi Di Salvo, Angela Tramonti, Erika Zangelmi, Alessio Peracchi, Andrea Secchi, Eugenia Polverini, Gabriele Giachin, Roberto Battistutta, Roberto Contestabile, Riccardo Percudani
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The increasing availability of experimental and computational protein structures entices their use for function prediction. Here we develop an automated procedure to identify enzymes involved in metabolic reactions by assessing substrate con
Externí odkaz:
https://doaj.org/article/14c67f718fbf493085d50d336b285301
Autor:
Rita Trirocco, Martina Pasqua, Angela Tramonti, Bianca Colonna, Alessandro Paiardini, Gianni Prosseda
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Shigella, the aetiological agent of human bacillary dysentery, controls the expression of its virulence determinants through an environmentally stimulated cascade of transcriptional activators. VirF is the leading activator and is essential
Externí odkaz:
https://doaj.org/article/3a1d8dba9a0249699f1926fb4804ac2c
Autor:
Rita Trirocco, Martina Pasqua, Angela Tramonti, Milena Grossi, Bianca Colonna, Alessandro Paiardini, Gianni Prosseda
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT The pathogenicity of Shigella, the intracellular pathogen responsible for human bacillary dysentery, depends on a coordinated and tightly regulated expression of its virulence determinants. This is the result of a cascade organization of its
Externí odkaz:
https://doaj.org/article/b1faa50eba4f4689bed407a2e0d7a367
Autor:
Alexandra I. Boyko, Irina S. Karlina, Lev G. Zavileyskiy, Vasily A. Aleshin, Artem V. Artiukhov, Thilo Kaehne, Alexander L. Ksenofontov, Sergey I. Ryabov, Anastasia V. Graf, Angela Tramonti, Victoria I. Bunik
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundThe DHTKD1-encoded 2-oxoadipate dehydrogenase (OADH) oxidizes 2-oxoadipate—a common intermediate of the lysine and tryptophan catabolism. The mostly low and cell-specific flux through these pathways, and similar activities of OADH and ubi
Externí odkaz:
https://doaj.org/article/c348e03e0bc340388c2b955d9ea9932f
Autor:
Natalia V. Balashova, Lev G. Zavileyskiy, Artem V. Artiukhov, Leonid A. Shaposhnikov, Olga P. Sidorova, Vladimir I. Tishkov, Angela Tramonti, Anastasia A. Pometun, Victoria I. Bunik
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Oxidized nicotinamide adenine dinucleotide (NAD+) is a biological molecule of systemic importance. Essential role of NAD+ in cellular metabolism relies on the substrate action in various redox reactions and cellular signaling. This work introduces an
Externí odkaz:
https://doaj.org/article/7c51da80f9bf48feafbe67a19e643485
Autor:
Elisa Mascolo, Anna Barile, Lorenzo Stufera Mecarelli, Noemi Amoroso, Chiara Merigliano, Arianna Massimi, Isabella Saggio, Torben Hansen, Angela Tramonti, Martino Luigi Di Salvo, Fabrizio Barbetti, Roberto Contestabile, Fiammetta Vernì
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract In eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B6 salvage pathway to produce pyridoxal 5′-phosphate (PLP), the active form of the vitamin, which is implicated in numerous crucial metabolic reactions. In Drosophila, mutations in the
Externí odkaz:
https://doaj.org/article/98cbd0cfb2e64e8c8b4f5fe2009a0e66
Autor:
Roberto Contestabile, Martino Luigi di Salvo, Victoria Bunik, Angela Tramonti, Fiammetta Vernì
Publikováno v:
Open Biology, Vol 10, Iss 3 (2020)
A perturbed uptake of micronutrients, such as minerals and vitamins, impacts on different human diseases, including cancer and neurological disorders. Several data converge towards a crucial role played by many micronutrients in genome integrity main
Externí odkaz:
https://doaj.org/article/3902a06c081a49d09f6b0f72605c3de8
Autor:
Dalila Boi, Fani Souvalidou, Davide Capelli, Federica Polverino, Grazia Marini, Roberta Montanari, Giorgio Pochetti, Angela Tramonti, Roberto Contestabile, Daniela Trisciuoglio, Patrizia Carpinelli, Camilla Ascanelli, Catherine Lindon, Alessandro De Leo, Michele Saviano, Roberto Di Santo, Roberta Costi, Giulia Guarguaglini, Alessandro Paiardini
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 13122 (2021)
Neuroblastoma is a severe childhood disease, accounting for ~10% of all infant cancers. The amplification of the MYCN gene, coding for the N-Myc transcription factor, is an essential marker correlated with tumor progression and poor prognosis. In neu
Externí odkaz:
https://doaj.org/article/95ae0f8e2a4a42f28065143f67055798
Autor:
Anna Barile, Philippa Mills, Martino L. di Salvo, Claudio Graziani, Victoria Bunik, Peter Clayton, Roberto Contestabile, Angela Tramonti
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 12013 (2021)
Several variants of the enzyme pyridox(am)ine 5′-phosphate oxidase (PNPO), responsible for a rare form of vitamin B6-dependent neonatal epileptic encephalopathy known as PNPO deficiency (PNPOD), have been reported. However, only a few of them have
Externí odkaz:
https://doaj.org/article/a79e06e8f164490eb7795b7699cbda64