Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Angela Styhler"'
Publikováno v:
Biomarkers of Hip Implant Function ISBN: 9780128215968
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e494e6eb2bc946100b9eaac68e45d3b
https://doi.org/10.1016/b978-0-12-821596-8.00005-7
https://doi.org/10.1016/b978-0-12-821596-8.00005-7
Autor:
Obakanyin J. Akinfosile, Ravindra V. Badhe, Mark Barba, Andrew R. Beadling, Reshid Berber, Divya Bijukumar, Benjamin Bloch, Michael G. Bryant, Alister J. Hart, Laura-Maria Horga, Harry Hothi, Peter James, Marc-Olivier Kiss, Andrew Manktelow, Vincent Massé, Mathew T. Mathew, Anne Neville, Shiraz A. Sabah, Angela Styhler, Pascal-André Vendittoli, Ilona Świtkowska
Publikováno v:
Biomarkers of Hip Implant Function ISBN: 9780128215968
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6ddd3ea27d3d6bd725cf2cb4b364a79
https://doi.org/10.1016/b978-0-12-821596-8.00009-4
https://doi.org/10.1016/b978-0-12-821596-8.00009-4
Autor:
Jocelyne Guay, Lei Zhang, Hao Wang, Yeeman K. Ramtohul, Sébastien Gagné, Zheng Huang, Angela Styhler
Publikováno v:
SLAS Discovery. 15:169-176
A multiplexed cell assay has been optimized to measure the activities of fatty acyl-CoA elongase, delta-5 desaturase (Delta5D), delta-6 desaturase (Delta6D), and delta-9 desaturase (Delta9D) together using (14)C-labeled tracers in HepG2 cells, which
Autor:
F. Otu, Joseph A. Mancini, Dwight Macdonald, Rebecca Dias, Daniel Dube, L. Zhang, Patrick Lacombe, Pascal Jean Denis Goetghebeur, Angela Styhler, David Claveau, Suzanna Liu, Yves Girard, Zheng Huang, Mervyn J. Turner, Michel Gallant, William M. Abraham, K. Ng, Thomas R. Jones, F. Laliberte, Robert N. Young, Donald W. Nicholson
Publikováno v:
Biochemical Pharmacology. 73:1971-1981
Type 4 phosphodiesterases (PDE4) inhibitors are emerging therapeutics in the treatment of a number of chronic disorders including asthma, chronic obstructive pulmonary disease (COPD) and cognitive disorders. This study delineates the preclinical prof
Autor:
Donald W. Nicholson, Andrea L.O. Hebb, George S. Robertson, Joseph A. Mancini, Trevor Owens, Nathalie Earl, Craig S. Moore, Richard Frenette, Angela Styhler
Publikováno v:
Moore, C S, Earl, N, Frenette, R, Styhler, A, Mancini, J A, Nicholson, D W, Hebb, A, Owens, T & Robertson, G S 2006, ' Peripheral phosphodiesterase 4 inhibition produced by 4-[2-(3,4-Bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) prevents experimental autoimmune encephalomyelitis ', Journal of Pharmacology and Experimental Therapeutics, vol. 319, no. 1, pp. 63-72 . https://doi.org/10.1124/jpet.106.106096
Administration of phosphodiesterase 4 (PDE4) inhibitors suppresses the pathogenesis associated with experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). In the present study, we compared the effects of rolipram
Autor:
Dwight Macdonald, Anthony Mastracchio, Hélène Perrier, Daniel Dubé, Michel Gallant, Patrick Lacombe, Denis Deschênes, Bruno Roy, John Scheigetz, Kevin Bateman, Chun Li, Laird A. Trimble, Stephen Day, Nathalie Chauret, Deborah A. Nicoll-Griffith, Jose M. Silva, Zheng Huang, France Laliberté, Susana Liu, Diane Ethier, Doug Pon, Eric Muise, Louise Boulet, Chi Chung Chan, Angela Styhler, Stella Charleson, Joseph Mancini, Paul Masson, David Claveau, Donald Nicholson, Mervyn Turner, Robert N. Young, Yves Girard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5241-5246
The discovery and SAR of a new series of substituted 8-arylquinoline PDE4 inhibitors are herein described. This work has led to the identification of several compounds with excellent in vitro and in vivo profiles, including a good therapeutic window
Autor:
Dennis M. Zaller, Stephen J. O'Keefe, Susana Liu, Shiow Chen, Donald W. Nicholson, David Claveau, Zheng Huang, Angela Styhler, Joseph A. Mancini
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 310:752-760
L-826,141 [4-(2-(3,4-bis-difluromethoxyphenyl)-2-(4-(1,1,1, 3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl)-3-methylpyridine-1-oxide] is a selective and potent inhibitor of phosphodiesterase 4 (PDE4) with an IC(50) value of 0.26 to 2.4 nM for i
Autor:
Yves Ducharme, Richard W Friesen, Marc Blouin, Bernard Côté, Daniel Dubé, Diane Ethier, Richard Frenette, France Laliberté, Joseph A Mancini, Paul Masson, Angela Styhler, Robert N Young, Yves Girard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1923-1926
The synthesis and the phosphodiesterase-4 (PDE4) inhibitory activity of 2-pyridinemethanol derivatives is described. The evaluation of the structure–activity relationship (SAR) in this series of novel PDE4 inhibitors led to the identification of co
Autor:
Richard W. Friesen, Yves Ducharme, Richard G. Ball, Marc Blouin, Louise Boulet, Bernard Côté, Richard Frenette, Mario Girard, Daniel Guay, Zheng Huang, Thomas R. Jones, France Laliberté, Joseph J. Lynch, Joseph Mancini, Evelyn Martins, Paul Masson, Eric Muise, Douglas J. Pon, Peter K. S. Siegl, Angela Styhler, Nancy N. Tsou, Mervyn J. Turner, Robert N. Young, Yves Girard
Publikováno v:
Journal of Medicinal Chemistry. 46:2413-2426
A SAR study on the tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors related to 1 is described. In addition to inhibitory potency against PDE4 and the lipopolysaccharide-induced production of TNFalpha in human whole blood, the binding
Publikováno v:
British Journal of Pharmacology. 126:979-988
The aim of this study was to assess the inhibitory activities of phosphodiesterase type 4 (PDE4) inhibitors on tumour necrosis factor-α (TNF-α) and leukotriene B4 (LTB4) production in a novel human whole blood assay. Lipopolysaccharide (LPS) stimul