Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Angela Steel"'
Publikováno v:
Biochemical and Biophysical Research Communications. 272:726-730
Histidyl residues in peptide transporters PepT1 and PepT2 are believed to participate in proton and substrate binding and to be crucial to the transporters' functional activities. In the present study, we performed mutagenesis of rabbit PepT1. We mut
Publikováno v:
Pharmaceutical Research. 17:526-532
Purpose. To examine the mechanism of inhibition of glycylsarcosine(GlySar) transport by quinapril and enalapril, and whether or notangiotensin converting enzyme (ACE) inhibitors are transported by PEPT2as well as by PEPT1.
Autor:
Angela Steel, Matthias A. Hediger
Publikováno v:
Physiology. 13:123-131
The expression of cloned Na+- and H+-coupled solute transporters in Xenopus laevis oocytes has permitted detailed molecular and biophysical analysis and illuminated unique mechanistic features. The identification of missense mutations in inherited di
Publikováno v:
Journal of Controlled Release. 46:31-38
The cellular uptake of small peptides such as di-, tri- and tetrapeptides and peptidomimetic drugs proceeds via specialized proton-coupled transporters (Refs. 1 , 2 , 3 , 4 , 5 , 6 ). The cDNA clones encoding the oligopeptide transporters PepT1 and P
Autor:
Andrew T. Gewirtz, Didier Merlin, James L. Madara, Mustapha Si-Tahar, Angela Steel, Matthias A. Hediger
Publikováno v:
The Journal of clinical investigation. 102(11)
Intestinal epithelial cells express hPepT1, an apical transporter responsible for the uptake of a broad array of small peptides. As these could conceivably include n-formyl peptides, we examined whether hPepT1 could transport the model n-formylated p
Autor:
Matthias A. Hediger, Michael F. Romero, Walter F. Boron, Davide Trotti, Angela Steel, Stephan Nussberger
Publikováno v:
The Journal of biological chemistry. 272(12)
Ion-coupled solute transporters exhibit pre-steady-tate currents that resemble those of voltage-dependent ion channels. These currents were assumed to be mostly due to binding and dissociation of the coupling ion near the extracellular transporter su
Autor:
Walter F. Boron, M. F. Romero, Stephan Nussberger, C. A. R. Boyd, Matthias A. Hediger, Angela Steel
Publikováno v:
Scopus-Elsevier
1. The intestinal H(+)-coupled peptide transporter PepT1, displays a broad substrate specificity and accepts most charged and neutral di- and tripeptides. To study the proton-to-peptide stoichiometry and the dependence of the kinetic parameters on ex
Autor:
Giles E. M. Martin, T. P. Mcdonald, Angela Steel, Michael T. Cairns, Gary J. Litherland, Peter J. F. Henderson
Publikováno v:
Biochemical Society transactions. 22(3)
Hormone Group, Membrane Group and Regulation in Metabolism Group Joint Colloquium Organized by S. A. Baldwin (University of Leeds), A. Burchell (University of Dundee), K. Docherty (Queen Elizabeth Hospital, Birmingham) and S. P. Shirazi-Beechey (Univ
Autor:
Giles E. M. Martin, Peter J. F. Henderson, Adrian R. Walmsley, Angela Steel, Terence P. McDonald
Publikováno v:
Antonie van Leeuwenhoek. 65(4)
GalP is the membrane protein responsible for H(+)-driven uptake of galactose into Escherichia coli. It is suggested to be the bacterial equivalent of the mammalian glucose transporter, GLUT1, since these proteins share sequence homology, recognise an
Publikováno v:
Biochemical Society Transactions. 26:S306-S306