Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Angela Serra"'
Autor:
Giorgia Migliaccio, Jack Morikka, Giusy del Giudice, Maaret Vaani, Lena Möbus, Angela Serra, Antonio Federico, Dario Greco
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 25, Iss , Pp 143-152 (2024)
Macrophage plasticity allows the adoption of distinct functional states in response to environmental cues. While unique transcriptomic profiles define these states, focusing solely on transcription neglects potential long-term effects. The investigat
Externí odkaz:
https://doaj.org/article/6bce4f91d2d447fda049f858a40f4f0c
Autor:
Giusy del Giudice, Angela Serra, Alisa Pavel, Marcella Torres Maia, Laura Aliisa Saarimäki, Michele Fratello, Antonio Federico, Harri Alenius, Bengt Fadeel, Dario Greco
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Hazard assessment is the first step in evaluating the potential adverse effects of chemicals. Traditionally, toxicological assessment has focused on the exposure, overlooking the impact of the exposed system on the observed toxicity. However
Externí odkaz:
https://doaj.org/article/3113aa82df4d44aaa47e36e21619b12f
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract The categorization of human diseases is mainly based on the affected organ system and phenotypic characteristics. This is limiting the view to the pathological manifestations, while it neglects mechanistic relationships that are crucial to d
Externí odkaz:
https://doaj.org/article/bb369be3e7084753a198b6d53ec88340
Autor:
Laura Aliisa Saarimäki, Michele Fratello, Alisa Pavel, Seela Korpilähde, Jenni Leppänen, Angela Serra, Dario Greco
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-8 (2023)
Abstract Adverse outcome pathways (AOPs) are emerging as a central framework in modern toxicology and other fields in biomedicine. They serve as an extension of pathway-based concepts by depicting biological mechanisms as causally linked sequences of
Externí odkaz:
https://doaj.org/article/d3ad4a6396b54178b02831faca984815
Autor:
Giusy del Giudice, Giorgia Migliaccio, Nicoletta D’Alessandro, Laura Aliisa Saarimäki, Marcella Torres Maia, Maria Emilia Annala, Jenni Leppänen, Lena Mӧbus, Alisa Pavel, Maaret Vaani, Anna Vallius, Laura Ylä‐Outinen, Dario Greco, Angela Serra
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
Assessing chemical safety is essential to evaluate the potential risks of chemical exposure to human health and the environment. Traditional methods relying on animal testing are being replaced by 3R (reduction, refinement, and replacement) principle
Externí odkaz:
https://doaj.org/article/835e8d1ef5494b02822cd4880376bad0
Autor:
Vittorio Fortino, Pia Anneli Sofia Kinaret, Michele Fratello, Angela Serra, Laura Aliisa Saarimäki, Audrey Gallud, Govind Gupta, Gerard Vales, Manuel Correia, Omid Rasool, Jimmy Ytterberg, Marco Monopoli, Tiina Skoog, Peter Ritchie, Sergio Moya, Socorro Vázquez-Campos, Richard Handy, Roland Grafström, Lang Tran, Roman Zubarev, Riitta Lahesmaa, Kenneth Dawson, Katrin Loeschner, Erik Husfeldt Larsen, Fritz Krombach, Hannu Norppa, Juha Kere, Kai Savolainen, Harri Alenius, Bengt Fadeel, Dario Greco
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Nanomaterials have a range of potential applications, however, toxicity remains a concern, limiting application and requiring extensive testing. Here, the authors report on a predictive framework made using a range of tests linking materials properti
Externí odkaz:
https://doaj.org/article/cd868a81e9ec4d95b4b5c073cf9197e3
Autor:
Angela Serra, Laura Aliisa Saarimäki, Alisa Pavel, Giusy del Giudice, Michele Fratello, Luca Cattelani, Antonio Federico, Omar Laurino, Veer Singh Marwah, Vittorio Fortino, Giovanni Scala, Pia Anneli Sofia Kinaret, Dario Greco
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1413-1426 (2022)
The recent advancements in toxicogenomics have led to the availability of large omics data sets, representing the starting point for studying the exposure mechanism of action and identifying candidate biomarkers for toxicity prediction. The current l
Externí odkaz:
https://doaj.org/article/7024c22e1ca4432d9e811816d36ed4d3
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4837-4849 (2022)
Big Data pervades nearly all areas of life sciences, yet the analysis of large integrated data sets remains a major challenge. Moreover, the field of life sciences is highly fragmented and, consequently, so is its data, knowledge, and standards. This
Externí odkaz:
https://doaj.org/article/43350388dcf84573a21327d56763af50
Autor:
Laura Aliisa Saarimäki, Antonio Federico, Iseult Lynch, Anastasios G. Papadiamantis, Andreas Tsoumanis, Georgia Melagraki, Antreas Afantitis, Angela Serra, Dario Greco
Publikováno v:
Scientific Data, Vol 8, Iss 1, Pp 1-10 (2021)
Measurement(s) microarray data • transcriptome • RNA • Toxicogenomics Technology Type(s) digital curation Factor Type(s) exposure to engineered nanomaterials Sample Characteristic - Organism Homo sapiens • Mus musculus • Rattus Machine-acce
Externí odkaz:
https://doaj.org/article/cc32931846cf4b098d33d4356ac0c2a8
Autor:
Antreas Afantitis, Georgia Melagraki, Panagiotis Isigonis, Andreas Tsoumanis, Dimitra Danai Varsou, Eugenia Valsami-Jones, Anastasios Papadiamantis, Laura-Jayne A. Ellis, Haralambos Sarimveis, Philip Doganis, Pantelis Karatzas, Periklis Tsiros, Irene Liampa, Vladimir Lobaskin, Dario Greco, Angela Serra, Pia Anneli Sofia Kinaret, Laura Aliisa Saarimäki, Roland Grafström, Pekka Kohonen, Penny Nymark, Egon Willighagen, Tomasz Puzyn, Anna Rybinska-Fryca, Alexander Lyubartsev, Keld Alstrup Jensen, Jan Gerit Brandenburg, Stephen Lofts, Claus Svendsen, Samuel Harrison, Dieter Maier, Kaido Tamm, Jaak Jänes, Lauri Sikk, Maria Dusinska, Eleonora Longhin, Elise Rundén-Pran, Espen Mariussen, Naouale El Yamani, Wolfgang Unger, Jörg Radnik, Alexander Tropsha, Yoram Cohen, Jerzy Leszczynski, Christine Ogilvie Hendren, Mark Wiesner, David Winkler, Noriyuki Suzuki, Tae Hyun Yoon, Jang-Sik Choi, Natasha Sanabria, Mary Gulumian, Iseult Lynch
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 583-602 (2020)
Nanotechnology has enabled the discovery of a multitude of novel materials exhibiting unique physicochemical (PChem) properties compared to their bulk analogues. These properties have led to a rapidly increasing range of commercial applications; this
Externí odkaz:
https://doaj.org/article/81b6870ad37945198bc7dfd358f34de2