Výsledky vyhledávání - "Angela Schukar"

Plasmid DNA fermentation strain and process-specific effects on vector yield, quality, and transgene expression

Autor: Sheryl Anderson, Clague P. Hodgson, James A. Williams, Angela Schukar, Jeremy Luke, Aaron E. Carnes, Justin M. Vincent

Publikováno v: Biotechnology and Bioengineering. 108:354-363

Industrial plasmid DNA manufacturing processes are needed to meet the quality, economy, and scale requirements projected for future commercial products. We report development of a modified plasmid fermentation copy number induction profile that incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822afb3f86140102fdd797083f636096
https://doi.org/10.1002/bit.22936

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Critical design criteria for minimal antibiotic-free plasmid vectors necessary to combine robust RNA Pol II and Pol III-mediated eukaryotic expression with high bacterial production yields

Autor: Sheryl Anderson, Aaron E. Carnes, James A. Williams, Angela Schukar, Justin M. Vincent, Jeremy Luke, Clague P. Hodgson

Publikováno v: The Journal of Gene Medicine. 12:818-831

Background For safety considerations, regulatory agencies recommend the elimination of antibiotic resistance markers and non-essential sequences from plasmid DNA-based gene medicines. In the present study, we analyzed antibiotic-free (AF) vector desi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520dc08ccf261fe8600f0321627f19fb
https://doi.org/10.1002/jgm.1499

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