Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Angela Schippers"'
Autor:
Sudheendra Hebbar Subramanyam, Judit Turyne Hriczko, Angeliki Pappas, Angela Schippers, Nobert Wagner, Kim Ohl, Klaus Tenbrock
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Tofactinib is a JAK inhibitor approved for ulcerative colitis in humans. Despite of its’ proven effectiveness in humans, mechanistic data are scarce on the effectiveness of Tofactinib in experimental colitis in mice. We induced experimenta
Externí odkaz:
https://doaj.org/article/fd2696ae3047486a812ed569421d260d
Autor:
Angela Schippers, Jessica Hübel, Felix Heymann, Thomas Clahsen, Sreepradha Eswaran, Sarah Schlepütz, Robin Püllen, Nikolaus Gaßler, Klaus Tenbrock, Frank Tacke, Norbert Wagner
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1227-1250.e1 (2021)
Background & Aims: Aberrant lymphocyte homing could potentially link inflammatory processes in the intestine and the liver, as distinct hepatobiliary diseases frequently develop as extra-intestinal manifestations in inflammatory bowel disease. In thi
Externí odkaz:
https://doaj.org/article/57a673f1ce494b60b0848a98334febcc
Autor:
Eva Verjans, Stephanie Kanzler, Kim Ohl, Annette D. Rieg, Nadine Ruske, Angela Schippers, Norbert Wagner, Klaus Tenbrock, Stefan Uhlig, Christian Martin
Publikováno v:
BMC Pulmonary Medicine, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background The acute respiratory distress syndrome (ARDS) is a serious disease in critically ill patients that is characterized by pulmonary dysfunctions, hypoxemia and significant mortality. Patients with immunodeficiency (e.g. SCID with T
Externí odkaz:
https://doaj.org/article/20f7a9d54aa64ba9a44efb52b6eaa349
Autor:
Kim Ohl, Helge Nickel, Halima Moncrieffe, Patricia Klemm, Anja Scheufen, Dirk Föll, Viktor Wixler, Angela Schippers, Norbert Wagner, Lucy R. Wedderburn, Klaus Tenbrock
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 16, Iss 1, Pp 1-9 (2018)
Abstract Background Inflammatory effector T cells trigger inflammation despite increased numbers of Treg cells in the synovial joint of patients suffering from juvenile idiopathic arthritis (JIA). The cAMP response element (CREM)α is known to play a
Externí odkaz:
https://doaj.org/article/5e072fbd3fc54050b8bb98a7a51a0503
Autor:
Anshu Babbar, Thomas C. A. Hitch, Oliver Pabst, Thomas Clavel, Jessica Hübel, Sreepradha Eswaran, Norbert Wagner, Angela Schippers
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
The gastrointestinal tract is an ideal habitat for diverse bacterial species that reside in a homeostatic balance with local tissue and significantly contribute to host health. Negative shifts in gut microbiota profiles, also known as dysbiosis, may
Externí odkaz:
https://doaj.org/article/dfcd292c168e49db8d29528efa3d921e
Autor:
Kristina Kuhbandner, Anna Hammer, Stefanie Haase, Elisa Terbrack, Alana Hoffmann, Angela Schippers, Norbert Wagner, Rehana Z. Hussain, William A. Miller-Little, Andrew Y. Koh, Joshua S. Stoolman, Benjamin M. Segal, Ralf A. Linker, Olaf Stüve
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Lymphocyte homing into the intestine is mediated by binding of leukocytes to mucosal addressin cell adhesion molecule 1 (MAdCAM-1), expressed on endothelial cells. Currently, the immune system of the gut is considered a major modulator not only of in
Externí odkaz:
https://doaj.org/article/a60a807de7e744a4ba1b34f3b3f64058
Autor:
Dóra Vojkovics, Zoltán Kellermayer, Fanni Gábris, Angela Schippers, Norbert Wagner, Gergely Berta, Kornélia Farkas, Péter Balogh
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Seeding of leukocytes to developing lymphoid tissues in embryonic and early postnatal age and to the mucosa throughout adulthood depends on the interaction between endothelial MAdCAM-1 addressin and its cognate ligand α4β7 integrin. Nkx2-3 as a tra
Externí odkaz:
https://doaj.org/article/d948d2b497b94492a5ec923c552ace84
Autor:
Hannah K. Drescher, Angela Schippers, Stefanie Rosenhain, Felix Gremse, Laura Bongiovanni, Alain de Bruin, Sreepradha Eswaran, Suchira U. Gallage, Dominik Pfister, Marta Szydlowska, Mathias Heikenwalder, Sabine Weiskirchen, Norbert Wagner, Christian Trautwein, Ralf Weiskirchen, Daniela C. Kroy
Publikováno v:
Cells, Vol 9, Iss 5, p 1106 (2020)
CD62L (L-Selectin) dependent lymphocyte infiltration is known to induce inflammatory bowel disease (IBD), while its function in the liver, especially in non-alcoholic steatohepatitis (NASH), remains unclear. We here investigated the functional role o
Externí odkaz:
https://doaj.org/article/20c11d986273406286d82ad6a8a5d9ab
Autor:
Kim Ohl, Athanassios Fragoulis, Patricia Klemm, Julian Baumeister, Wiebke Klock, Eva Verjans, Svenja Böll, Julia Möllmann, Michael Lehrke, Ivan Costa, Bernd Denecke, Angela Schippers, Johannes Roth, Norbert Wagner, Christoph Wruck, Klaus Tenbrock
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Arising in inflammatory conditions, myeloid-derived suppressor cells (MDSCs) are constantly confronted with intracellular and extracellular reactive oxygen species molecules and oxidative stress. Generating mice with a constitutive activation of Nucl
Externí odkaz:
https://doaj.org/article/d82f2921133947cf87861bdc7f2619c0
Autor:
Kim Ohl, Anastasia Wiener, Ralph Lippe, Carolin Zorn, Johannes Roth, Norbert Wagner, Angela Schippers, Klaus Tenbrock
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
The cAMP responsive element modulator alpha (CREMα) plays a role in autoimmunity and in particular in systemic lupus erythematosus. CREMα negatively regulates IL-2 transcription and activates IL-17 expression by direct transcriptional mechanisms. T
Externí odkaz:
https://doaj.org/article/9acc6e71c6e54c16bb5c6cbfb658f767