Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Angela Scafonas"'
Autor:
William J. Ray, Chang Bai, Stephen E. Alves, Tara E. Cusick, Brenda L Pennypacker, Evan E. Opas, Michael J. Chisamore, Carlo J. Gambone, Damien Ferraro, David J. Bettoun, Azriel Schmidt, Hilary A. Wilkinson, Angela Scafonas, Michael A. Gentile, Osvaldo A. Flores, Paul Hodor, Meissner Robert S, James J. Perkins
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 143:29-39
Prostate cancer (PCa) initially responds to inhibition of androgen receptor (AR) signaling, but inevitably progresses to hormone ablation-resistant disease. Much effort is focused on optimizing this androgen deprivation strategy by improving hormone
Autor:
Pascale V. Nantermet, Thomayant Prueksaritanont, William J. Ray, James J. Perkins, Chih-Tai Leu, Fang Chen, Azriel Schmidt, Mark E. Duggan, Viera Kasparcova, Sharon Adamski, Donald B. Kimmel, Leonard P. Freedman, SuJane Rutledge, T. Cusick, Brenda L Pennypacker, George D. Hartman, Jiabing Wang, P. Masarachia, Meissner Robert S, Shun-ichi Harada, Paul Hodor, Robert L. Vogel, Chang Bai, Hai-Zhuan Zhang, Sheila McElwee-Witmer, Helen J. Mitchell, Michael A. Gentile, Evan E. Opas, Angela Scafonas, Yuntae Kim
Publikováno v:
Journal of Biological Chemistry. 285:17054-17064
Selective androgen receptor modulators (SARMs) are androgen receptor (AR) ligands that induce anabolism while having reduced effects in reproductive tissues. In various experimental contexts SARMs fully activate, partially activate, or even antagoniz
Autor:
Soumya P. Sahoo, Donald B. Kimmel, P. Masarachia, Pascale V. Nantermet, Meissner Robert S, Fang Chen, William J. Ray, Dwight A. Towler, Shun Ichi Harada, Chang Bai, Angela Scafonas, Mark E. Duggan, Brenda L Pennypacker, Su Jane Rutledge, Azriel Schmidt, Gideon A. Rodan, Sheila McElwee-Witmer, Robert L. Vogel, Michael A. Gentile, George D. Hartman, Yuntae Kim
Publikováno v:
Journal of Biological Chemistry. 284:36367-36376
Androgen replacement therapy is a promising strategy for the treatment of frailty; however, androgens pose risks for unwanted effects including virilization and hypertrophy of reproductive organs. Selective Androgen Receptor Modulators (SARMs) retain
Autor:
Gideon A. Rodan, Dwight A. Towler, Azriel Schmidt, Elizabeth T. Birzin, Pascale V. Nantermet, Evan E. Opas, James M. Schaeffer, Hilary A. Wilkinson, Lawrence F. Colwell, Robert R. Wilkening, Angela Scafonas
Publikováno v:
Maturitas. 64:46-51
Objective To test the role of ERβ in the control of estrogen-dependent thermoregulation in rats. Methods Test the ability of an ERβ-selective ligand to suppress the elevation in basal rat tail skin temperature (TST) caused by ovariectomy (OVX). Res
Autor:
Azriel Schmidt, Chang Bai, Angela Scafonas, Carlo J. Gambone, Su Jane Rutledge, Leonard P. Freedman, Sheila McElwee-Witmer, Robert L. Vogel, Paul Hodor, Oliver Chen, David J. Bettoun
Publikováno v:
Journal of Biological Chemistry. 280:38898-38901
Signaling by androgens and interferons (IFN) plays an important role in prostate cancer initiation and progression. Using microarray analysis, we describe here a functional cross-talk between dihydrotestosterone and interferon signaling. Glutathione
Autor:
Kristin Knecht, Chang Bai, Chih-Tai Leu, Shun-ichi Harada, H. Zhang, Angela Scafonas, Azriel Schmidt, Alfred A. Reszka, Su Jane Rutledge, Leonard P. Freedman, Fang Chen, Carlo J. Gambone, Robert L. Vogel, Viera Kasparcova
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 91:247-257
Androgens play important endocrine roles in development and physiology. Here, we characterize activities of two “Andro” prohormones, androstenedione (A-dione) and 4-androsten-3β,17β-diol (A-diol) in MDA-MB-453 (MDA) and LNCaP cells. A-dione and
Autor:
Kenneth J. Soprano, Jerome L. Gabriel, Dianne Robert Soprano, Christopher L. Wolfgang, Angela Scafonas
Publikováno v:
Journal of Biological Chemistry. 272:11244-11249
The diverse biological actions of retinoic acid (RA) are mediated by retinoic acid receptors (RARs) and retinoid X receptors. Although it has been suggested that the ligand binding domains (LBDs) of RARs share the same novel folding pattern, many RAR
Autor:
Gideon A. Rodan, Seongkon Kim, Frank P. DiNinno, Elizabeth T. Birzin, Donald B. Kimmel, Qin Su, Milton L. Hammond, Qiang Tan, Azriel Schmidt, Xiaoli Shirley Hou, Angela Scafonas, Helen Chen, Alfred A. Reszka, Dwight A. Towler, Susan P. Roher
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 110(3-5)
Estradiol receptors (ER), ERalpha and ERbeta, are ligand-dependent transcription factors that regulate gene expression. Human and murine genetics suggest that ERalpha is the key target for estradiol action on bone, uterus and breast. To date, the mol
Autor:
Joel Yudkovitz, Helen Chen, Azriel Schmidt, Milton L. Hammond, Lorraine Lipfert, Qiang Tan, Frank P. DiNinno, Nan Wei, Sudha Warrier, Alfred A. Reszka, John E. Fisher, Qin Su, Leonard P. Freedman, Gideon A. Rodan, Seongkon Kim, Fang Chen, Angela Scafonas, Elizabeth T. Birzin, Susan P. Rohrer
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 20(3)
Estrogen receptor alpha (ERalpha) serine 118 (Ser118) phosphorylation modulates activation function-1 (AF1) function. Correct positioning of helix 12 promotes agonist-dependent recruitment of cyclin-dependent kinase-7 to catalyze this event. In this
Autor:
Zhen-ping Zhang, Lan X. Chen, Kenneth J. Soprano, Dianne Robert Soprano, Jerome L. Gabriel, Angela Scafonas, R. Christopher Cavalli
Publikováno v:
The Journal of biological chemistry. 270(9)
Cellular retinoic acid-binding protein type II (CRABP-II) is one of two small molecular weight, cytosolic proteins which specifically bind retinoic acid (RA). Crystallographic and site-directed mutagenesis studies of several related proteins have ind