Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Angela Rigopoulos"'
Autor:
Peter W. Janes, Adam C. Parslow, Diana Cao, Angela Rigopoulos, Fook-Thean Lee, Sylvia J. Gong, Glenn A. Cartwright, Ingrid J. G. Burvenich, Ulf Eriksson, Terrance G. Johns, Fiona E. Scott, Andrew M. Scott
Publikováno v:
Cancers, Vol 16, Iss 10, p 1902 (2024)
The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are key regulators of blood vessel formation, including in tumors, where their deregulated function can promote the production of aberrant, leaky blood vessels, supporting t
Externí odkaz:
https://doaj.org/article/73f760402f1a4f2cba67b5eecc8d20f9
Autor:
Christian W. Wichmann, Yit Wooi Goh, Adam C. Parslow, Angela Rigopoulos, Nancy Guo, Andrew M. Scott, Uwe Ackermann, Jonathan M. White
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 5, Iss 1, Pp 1-20 (2020)
Abstract Background Targeted therapy of HER2 positive breast cancer has led to clinical success in some cases with primary and secondary resistance being major obstacles. Due to the substantial involvement of mTOR kinase in cell growth and proliferat
Externí odkaz:
https://doaj.org/article/46ec3ba522d9491aa0fbc6b52e05ab56
Autor:
Mercedes Dávalos-Salas, Magdalene K. Montgomery, Camilla M. Reehorst, Rebecca Nightingale, Irvin Ng, Holly Anderton, Sheren Al-Obaidi, Analia Lesmana, Cameron M. Scott, Paul Ioannidis, Hina Kalra, Shivakumar Keerthikumar, Lars Tögel, Angela Rigopoulos, Sylvia J. Gong, David S. Williams, Prusoth Yoganantharaja, Kim Bell-Anderson, Suresh Mathivanan, Yann Gibert, Scott Hiebert, Andrew M. Scott, Matthew J. Watt, John M. Mariadason
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Histone deacetylase 3 (HDAC3) is a regulator of lipid homeostasis in several tissues, however, its role in intestinal lipid metabolism was not yet known. Here the authors study intestine specific HDAC3 knock out mice and report that these animals hav
Externí odkaz:
https://doaj.org/article/517f7ab37ce74aff9258c9ede119de9a
Autor:
Christian Wichmann, Andrew Scott, Fiona Scott, Ingrid Burvenich, Alexander McDonald, Nancy Guo, Angela Rigopoulos, Raul Soikes, Steven Angelides, Reinhard von Roemeling
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/01b02f2da1a94413b01d9c610d15a554
Autor:
Tanmay M. Shekhar, Ingrid J. G. Burvenich, Michael A. Harris, Angela Rigopoulos, Damien Zanker, Alex Spurling, Belinda S. Parker, Carl R. Walkley, Andrew M. Scott, Christine J. Hawkins
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-18 (2019)
Abstract Background Current therapies fail to cure over a third of osteosarcoma patients and around three quarters of those with metastatic disease. “Smac mimetics” (also known as “IAP antagonists”) are a new class of anti-cancer agents. Prev
Externí odkaz:
https://doaj.org/article/99b7b10e16ee4f3fadd02b3425b1778e
Autor:
Katie S. Ardipradja, Christian W. Wichmann, Kevin Hickson, Angela Rigopoulos, Karen M. Alt, Hannah A. Pearce, Xiaowei Wang, Graeme O’Keefe, Andrew M. Scott, Karlheinz Peter, Christoph E. Hagemeyer, Uwe Ackermann
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 6886 (2022)
Positron emission tomography is the imaging modality of choice when it comes to the high sensitivity detection of key markers of thrombosis and inflammation, such as activated platelets. We, previously, generated a fluorine-18 labelled single-chain a
Externí odkaz:
https://doaj.org/article/fd727e31ca3b4ea9a2f6fc6944091232
Autor:
Puey-Ling Chia, Sagun Parakh, Ming-Sound Tsao, Nhu-An Pham, Hui K. Gan, Diana Cao, Ingrid J. G. Burvenich, Angela Rigopoulos, Edward B. Reilly, Thomas John, Andrew M. Scott
Publikováno v:
Pharmaceuticals, Vol 13, Iss 10, p 289 (2020)
Epidermal growth factor receptor (EGFR) is highly overexpressed in malignant mesothelioma (MM). MAb806 is a novel anti-EGFR antibody that selectively targets a tumor-selective epitope. MAb806-derived antibody drug conjugates (ADCs), ABT-414, ABBV-221
Externí odkaz:
https://doaj.org/article/fe2d9f07976d49e8880342331b1b8d0a
Autor:
Fook T. Lee PhD, Ingrid J. G. Burvenich PhD, Nancy Guo MBBS, MSc, Pece Kocovski BSc (Honors), Henri Tochon-Danguy PhD, Uwe Ackermann PhD, Graeme J. O’Keefe PhD, Sylvia Gong PhD, Angela Rigopoulos BSc, MSc, Zhanqi Liu MBBS, PhD, Hui K. Gan MBBS, FRACP, PhD, Andrew M. Scott MBBS, FRACP, MD
Publikováno v:
Molecular Imaging, Vol 15 (2016)
Purpose: The aims of the study were to develop and evaluate a novel residualizing peptide for labeling internalizing antibodies with 124 I to support clinical development using immuno-positron emission tomography (PET). Methods: The anti-epidermal gr
Externí odkaz:
https://doaj.org/article/ec906d2158ff44d483cd65511d1e09d3
Autor:
Catherine G. Fitzgerald Dickmann, Alexander F. McDonald, Nhi Huynh, Angela Rigopoulos, Zhanqi Liu, Nancy Guo, Laura D. Osellame, Michael A. Gorman, Michael W. Parker, Hui K. Gan, Andrew M. Scott, Uwe Ackermann, Ingrid J. G. Burvenich, Jonathan M. White
Publikováno v:
Chemical Communications. 59:3126-3129
A fluorine-18 labelled probe was developed to target bromodomain and extraterminal (BET) proteins for molecular imaging of cancer with positron emission tomography.
Autor:
Christian W. Wichmann, Stan Poniger, Nancy Guo, Peter Roselt, Stacey E. Rudd, Paul S. Donnelly, Benjamin Blyth, Jessica Van Zuylekom, Angela Rigopoulos, Ingrid J.G. Burvenich, Laurence Morandeau, Shifaza Mohamed, Anna K. Nowak, Fiona Hegi-Johnson, Michael MacManus, Andrew M. Scott
Publikováno v:
Nuclear Medicine and Biology. :108351