Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Angela Relogio"'
Publikováno v:
EBioMedicine, Vol 110, Iss , Pp 105451- (2024)
Summary: The circadian clock, a fundamental cellular mechanism, regulates the rhythmic expression of numerous genes and biological processes across various organs. Disruptions in this system, driven by genetic or environmental factors, have been repo
Externí odkaz:
https://doaj.org/article/250b6ee6d621477d8c8e4818e1ecf8e5
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-17 (2022)
Abstract Emerging evidence points towards a regulatory role of the circadian clock in alternative splicing (AS). Whether alterations in core-clock components may contribute to differential AS events is largely unknown. To address this, we carried out
Externí odkaz:
https://doaj.org/article/34738d771b284b6eb58f43a2560c805b
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5170-5183 (2021)
Scheduling anticancer drug administration over 24 h may critically impact treatment success in a patient-specific manner. Here, we address personalization of treatment timing using a novel mathematical model of irinotecan cellular pharmacokinetics an
Externí odkaz:
https://doaj.org/article/d99649a237284b679a0573aca4da6df1
Autor:
Müge Yalçin, Annakarina Mundorf, Freya Thiel, Sandra Amatriain-Fernández, Ida Schulze Kalthoff, Jan-Carl Beucke, Henning Budde, Susan Garthus-Niegel, Jutta Peterburs, Angela Relógio
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
A variety of organisms including mammals have evolved a 24h, self-sustained timekeeping machinery known as the circadian clock (biological clock), which enables to anticipate, respond, and adapt to environmental influences such as the daily light and
Externí odkaz:
https://doaj.org/article/a1d43ea8a25842b3b75ff80d6ec6707e
Autor:
Laetitia S. Gaspar, Janina Hesse, Müge Yalçin, Bárbara Santos, Catarina Carvalhas-Almeida, Mafalda Ferreira, Joaquim Moita, Angela Relógio, Cláudia Cavadas, Ana Rita Álvaro
Publikováno v:
EBioMedicine, Vol 65, Iss , Pp 103248- (2021)
Background: Obstructive Sleep Apnea (OSA) is a highly prevalent and underdiagnosed sleep disorder. Recent studies suggest that OSA might disrupt the biological clock, potentially causing or worsening OSA-associated comorbidities. However, the effect
Externí odkaz:
https://doaj.org/article/36f3ff3af7304563ae003a8712b79787
Autor:
Alireza Basti, Müge Yalçin, David Herms, Janina Hesse, Ouda Aboumanify, Yin Li, Zita Aretz, Josefin Garmshausen, Rukeia El-Athman, Maria Hastermann, Dieter Blottner, Angela Relógio
Publikováno v:
BMJ Open Sport & Exercise Medicine, Vol 7, Iss 1 (2021)
Objectives In this study, we investigated daily fluctuations in molecular (gene expression) and physiological (biomechanical muscle properties) features in human peripheral cells and their correlation with exercise performance.Methods 21 healthy part
Externí odkaz:
https://doaj.org/article/8a41bc736916486b8ffc89002d93fcd0
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101551- (2020)
Summary: Impairment of circadian rhythms impacts carcinogenesis. SMAD4, a clock-controlled gene and central component of the TGFβ canonical pathway, is frequently mutated in pancreatic ductal adenocarcinoma (PDA), leading to decreased survival. Here
Externí odkaz:
https://doaj.org/article/d459808ebaea48598888d1cefc720b7e
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract A bidirectional interaction between the circadian network and effector mechanisms of immunity brings on a proper working of both systems. In the present study, we used Hodgkin lymphoma (HL) as an experimental model for a type of cancer invol
Externí odkaz:
https://doaj.org/article/2c1c7ad1f07245c49786e246d325ae18
Autor:
Luise Fuhr, Rukeia El-Athman, Rosella Scrima, Olga Cela, Annalucia Carbone, Henning Knoop, Yin Li, Karen Hoffmann, Mikko O. Laukkanen, Francesco Corcione, Ralf Steuer, Thomas F. Meyer, Gianluigi Mazzoccoli, Nazzareno Capitanio, Angela Relógio
Publikováno v:
EBioMedicine, Vol 33, Iss , Pp 105-121 (2018)
An endogenous molecular clockwork drives various cellular pathways including metabolism and the cell cycle. Its dysregulation is able to prompt pathological phenotypes including cancer. Besides dramatic metabolic alterations, cancer cells display sev
Externí odkaz:
https://doaj.org/article/ef1dbb151a5a449aa1c455cb4bcb8751
Publikováno v:
EBioMedicine, Vol 33, Iss , Pp 68-81 (2018)
Accumulating evidence points to a significant role of the circadian clock in the regulation of splicing in various organisms, including mammals. Both dysregulated circadian rhythms and aberrant pre-mRNA splicing are frequently implicated in human dis
Externí odkaz:
https://doaj.org/article/8ec81f668bbb4668b336db3f8fc00836