Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Angela R. Corrigan"'
Autor:
Hongying Duan, Angela R. Corrigan, Cheng Cheng, Andrea Biju, Christopher A. Gonelli, Adam S. Olia, I-Ting Teng, Kai Xu, Sijy O’Dell, Sandeep Narpala, Mike Castro, Leonid Serebryannyy, Jennifer Wang, Danealle K. Parchment, Edward K. Sarfo, Jelle van Schooten, John-Paul Todd, Shuishu Wang, Darcy R. Harris, Hui Geng, Alexander J. Jafari, Ruth A. Woodward, Nicole A. Doria-Rose, Kathryn E. Foulds, Adrian B. McDermott, Marit J. van Gils, Richard A. Koup, Theodore C. Pierson, Peter D. Kwong, John R. Mascola
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108877- (2024)
Summary: Soluble ‘SOSIP’-stabilized HIV-1 envelope glycoprotein (Env) trimers elicit dominant antibody responses targeting their glycan-free base regions, potentially diminishing neutralizing responses. Previously, using a nonhuman primate model,
Externí odkaz:
https://doaj.org/article/bc8aa3b518694807a3c5228e93d29f17
Autor:
Adam S. Olia, Cheng Cheng, Tongqing Zhou, Andrea Biju, Darcy R. Harris, Anita Changela, Hongying Duan, Vera B. Ivleva, Wing-Pui Kong, Li Ou, Reda Rawi, Yaroslav Tsybovsky, David J. Van Wazer, Angela R. Corrigan, Christopher A. Gonelli, Myungjin Lee, Krisha McKee, Sandeep Narpala, Sijy O’Dell, Danealle K. Parchment, Erik-Stephane D. Stancofski, Tyler Stephens, Ivy Tan, I-Ting Teng, Shuishu Wang, Qing Wei, Yongping Yang, Zhengrong Yang, Baoshan Zhang, Jan Novak, Matthew B. Renfrow, Nicole A. Doria-Rose, Richard A. Koup, Adrian B. McDermott, Jason G. Gall, Q. Paula Lei, John R. Mascola, Peter D. Kwong
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107403- (2023)
Summary: Soluble HIV-1-envelope (Env) trimers elicit immune responses that target their solvent-exposed protein bases, the result of removing these trimers from their native membrane-bound context. To assess whether glycosylation could limit these ba
Externí odkaz:
https://doaj.org/article/f61151545f45450b8eb0961391496066
Autor:
Katherine V. Houser, Martin R. Gaudinski, Myra Happe, Sandeep Narpala, Raffaello Verardi, Edward K. Sarfo, Angela R. Corrigan, Richard Wu, Ro Shauna Rothwell, Laura Novik, Cynthia S. Hendel, Ingelise J. Gordon, Nina M. Berkowitz, Cora Trelles Cartagena, Alicia T. Widge, Emily E. Coates, Larisa Strom, Somia Hickman, Michelle Conan-Cibotti, Sandra Vazquez, Olga Trofymenko, Sarah Plummer, Judy Stein, Christopher L. Case, Martha Nason, Andrea Biju, Danealle K. Parchment, Anita Changela, Cheng Cheng, Hongying Duan, Hui Geng, I-Ting Teng, Tongqing Zhou, Sarah O'Connell, Chris Barry, Kevin Carlton, Jason G. Gall, Britta Flach, Nicole A. Doria-Rose, Barney S. Graham, Richard A. Koup, Adrian B. McDermott, John R. Mascola, Peter D. Kwong, Julie E. Ledgerwood
Publikováno v:
EClinicalMedicine, Vol 48, Iss , Pp 101477- (2022)
Background: Advances in therapeutic drugs have increased life-expectancies for HIV-infected individuals, but the need for an effective vaccine remains. We assessed safety and immunogenicity of HIV-1 vaccine, Trimer 4571 (BG505 DS-SOSIP.664) adjuvante
Externí odkaz:
https://doaj.org/article/49b7b8d527474cb4acebedb3025b53dc
Autor:
Li Ou, Krishana Gulla, Andrea Biju, Daniel W. Biner, Tatsiana Bylund, Anita Changela, Steven J. Chen, Cheng-Yan Zheng, Nicole Cibelli, Angela R. Corrigan, Hongying Duan, Christopher A. Gonelli, Wing-Pui Kong, Cheng Cheng, Sijy O’Dell, Edward K. Sarfo, Andrew Shaddeau, Shuishu Wang, Alison Vinitsky, Yanhong Yang, Baoshan Zhang, Yaqiu Zhang, Richard A. Koup, Nicole A. Doria-Rose, Jason G. Gall, John R. Mascola, Peter D. Kwong
Publikováno v:
Vaccines, Vol 10, Iss 11, p 1916 (2022)
Conjugate-vaccine immunogens require three components: a carrier protein, an antigen, and a crosslinker, capable of coupling antigen to carrier protein, while preserving both T-cell responses from carrier protein and B-cell responses from antigen. We
Externí odkaz:
https://doaj.org/article/85de9bcde4414298a03518a9e4924ae9
Autor:
Angela R. Corrigan, Hongying Duan, Cheng Cheng, Christopher A. Gonelli, Li Ou, Kai Xu, Megan E. DeMouth, Hui Geng, Sandeep Narpala, Sarah O’Connell, Baoshan Zhang, Tongqing Zhou, Manjula Basappa, Jeffrey C. Boyington, Steven J. Chen, Sijy O’Dell, Amarendra Pegu, Tyler Stephens, Yaroslav Tsybovsky, Jelle van Schooten, John P. Todd, Shuishu Wang, Nicole A. Doria-Rose, Kathryn E. Foulds, Richard A. Koup, Adrian B. McDermott, Marit J. van Gils, Peter D. Kwong, John R. Mascola
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108937- (2021)
Summary: Soluble “SOSIP”-stabilized envelope (Env) trimers are promising HIV-vaccine immunogens. However, they induce high-titer responses against the glycan-free trimer base, which is occluded on native virions. To delineate the effect on base r
Externí odkaz:
https://doaj.org/article/fb8248bcdadc4968b6e0d3308bbd4c7a
Autor:
Cheng Cheng, Hongying Duan, Kai Xu, Gwo-Yu Chuang, Angela R. Corrigan, Hui Geng, Sijy O’Dell, Li Ou, Michael Chambers, Anita Changela, Xuejun Chen, Kathryn E. Foulds, Edward K. Sarfo, Alexander J. Jafari, Kurt R. Hill, Rui Kong, Kevin Liu, John P. Todd, Yaroslav Tsybovsky, Raffaello Verardi, Shuishu Wang, Yiran Wang, Winston Wu, Tongqing Zhou, Frank J. Arnold, Nicole A. Doria-Rose, Richard A. Koup, Adrian B. McDermott, Diana G. Scorpio, Michael Worobey, Lawrence Shapiro, John R. Mascola, Peter D. Kwong
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107981- (2020)
Summary: The HIV fusion peptide (FP) is a promising vaccine target. FP-directed monoclonal antibodies from vaccinated macaques have been identified that neutralize up to ∼60% of HIV strains; these vaccinations, however, have involved ∼1 year with
Externí odkaz:
https://doaj.org/article/bb3774735aad404788e444f06012cb42
Autor:
Mallika Sastry, Anita Changela, Jason Gorman, Kai Xu, Gwo-Yu Chuang, Chen-Hsiang Shen, Cheng Cheng, Hui Geng, Sijy O'Dell, Li Ou, Reda Rawi, Mateo Reveiz, Guillaume B. E. Stewart-Jones, Shuishu Wang, Baoshan Zhang, Tongqing Zhou, Andrea Biju, Michael Chambers, Xuejun Chen, Angela R. Corrigan, Bob C. Lin, Mark K. Louder, Krisha McKee, Alexandra F. Nazzari, Adam S. Olia, Danealle K. Parchment, Edward K. Sarfo, Tyler Stephens, Jonathan Stuckey, Yaroslav Tsybovsky, Raffaello Verardi, Yiran Wang, Cheng-Yan Zheng, Yuling Chen, Nicole A. Doria-Rose, Adrian B. McDermott, John R. Mascola, Peter D. Kwong
Publikováno v:
Journal of Virology. 97
The HIV-1 fusion peptide has been identified as a site for elicitation of broadly neutralizing antibodies, with prior studies demonstrating that priming with fusion peptide-based immunogens and boosting with soluble envelope (Env) trimers can elicit
Autor:
Nicole A. Doria-Rose, Cheng Cheng, Tyler Stephens, Shuishu Wang, Steven J. Chen, Peter D. Kwong, John Paul Todd, Christopher A. Gonelli, Amarendra Pegu, Sijy O'Dell, Richard A. Koup, Vrc Production Program, Kai Xu, Baoshan Zhang, John R. Mascola, Adrian B. McDermott, Hongying Duan, Jelle van Schooten, Li Ou, Jeffrey C. Boyington, Manjula Basappa, Angela R. Corrigan, Sarah O’Connell, Sandeep Narpala, Kathryn E. Foulds, Megan E. DeMouth, Marit J. van Gils, Yaroslav Tsybovsky, Tongqing Zhou, Hui Geng
Publikováno v:
Cell reports, 35(1):108937. Cell Press
Cell Reports, Vol 35, Iss 1, Pp 108937-(2021)
Cell reports
Cell Reports, Vol 35, Iss 1, Pp 108937-(2021)
Cell reports
SUMMARY Soluble “SOSIP”-stabilized envelope (Env) trimers are promising HIV-vaccine immunogens. However, they induce high-titer responses against the glycan-free trimer base, which is occluded on native virions. To delineate the effect on base re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25456efa28d5031ea6efc66dceedf09
https://pure.amc.nl/en/publications/fusion-peptide-priming-reduces-immune-responses-to-hiv1-envelope-trimer-base(8874d9ca-be54-4482-9c96-b1171a7bdf93).html
https://pure.amc.nl/en/publications/fusion-peptide-priming-reduces-immune-responses-to-hiv1-envelope-trimer-base(8874d9ca-be54-4482-9c96-b1171a7bdf93).html
Autor:
Li Ou, Jeffrey C. Boyington, Michael Chambers, Yongping Yang, John R. Mascola, Adam S. Olia, Stephen D. Schmidt, Peter D. Kwong, Shuishu Wang, Anita Changela, Rui Kong, Cheng Cheng, Angela R. Corrigan, Edward K Sarfo, Gwo-Yu Chuang, Nicole A. Doria-Rose, Yaroslav Tsybovsky, Raffaello Verardi, Winston Wu, Reda Rawi, Hui Geng, Adrian B. McDermott, Sandeep Narpala, Baoshan Zhang, Yen-Ting Lai, Kai Xu
Publikováno v:
J Virol
HIV-1 envelope (Env) trimers, stabilized in a prefusion-closed conformation, can elicit humoral responses capable of neutralizing HIV-1 strains closely matched in sequence to the immunizing strain. One strategy to increase elicited neutralization bre
Autor:
Edward K Sarfo, Nicole A. Doria-Rose, Diana G. Scorpio, Raffaello Verardi, Sijy O'Dell, Michael Worobey, Yaroslav Tsybovsky, Kathryn E. Foulds, Gwo-Yu Chuang, Frank J. Arnold, Cheng Cheng, Tongqing Zhou, Li Ou, Hui Geng, Winston Wu, Kevin Liu, John Paul Todd, Alexander J. Jafari, Michael Chambers, Richard A. Koup, Adrian B. McDermott, Peter D. Kwong, Xuejun Chen, Kurt R. Hill, Hongying Duan, Rui Kong, Shuishu Wang, Vrc Production Program, Yiran Wang, Anita Changela, Lawrence Shapiro, Angela R. Corrigan, Kai Xu, John R. Mascola
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107981-(2020)
Summary: The HIV fusion peptide (FP) is a promising vaccine target. FP-directed monoclonal antibodies from vaccinated macaques have been identified that neutralize up to ∼60% of HIV strains; these vaccinations, however, have involved ∼1 year with