Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Angela R Stermer"'
Autor:
Susan J. Hall, Kathleen Hwang, Enrica Bianchi, Hui Li, Mark Sigman, Angela R Stermer, Kim Boekelheide, Timothy Nolan
Publikováno v:
Reproductive Toxicology. 104:44-51
Assessing male reproductive toxicity of environmental and therapeutic agents relies on the histopathology of the testis and epididymis in a pre-clinical setting. Animal histopathology poorly correlates with human sperm parameters, and none of these c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4654fe318f9a1e6100651c8afc7a63a
https://doi.org/10.1016/j.reprotox.2021.06.012
https://doi.org/10.1016/j.reprotox.2021.06.012
Publikováno v:
Toxicol Sci
Testicular histology and semen parameters are considered the gold standards when determining male reproductive toxicity. Ethylene glycol monomethyl ether (EGME) is a testicular toxicant with well-described effects on histopathology and sperm paramete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eeffcaa608531a2395dc001ae530bb8
https://doi.org/10.1093/toxsci/kfz041
https://doi.org/10.1093/toxsci/kfz041
Publikováno v:
Reproduction. 156:35-46
The testis is an organ that maintains an immune suppressive environment. We previously revealed that exposure of pre-pubertal rats to an acute dose of a well-described Sertoli cell toxicant, mono-(2-ethylhexyl) phthalate (MEHP), leads to an accumulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b1e92efa816c108d0b55f5f94ce52d
https://doi.org/10.1530/rep-18-0093
https://doi.org/10.1530/rep-18-0093
Autor:
Samantha J. Madnick, Enrica Bianchi, Weihsueh A. Chiu, Angela R Stermer, Chimeddulam Dalaijamts, Shelby Wilson, Cathy Yue Bai, Susan J. Hall, David Klein, Kim Boekelheide
Publikováno v:
Environ Toxicol Pharmacol
Trichloroethylene (TCE) is a persistent environmental contaminant that causes male reproductive toxicity. We investigated whether transient increases in TCE exposure modulated male reproductive toxicity by exposing rats via daily oral to repeated gav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f685b7096331a6dfdb31d866a8b584fe
https://doi.org/10.1016/j.etap.2019.02.003
https://doi.org/10.1016/j.etap.2019.02.003
Autor:
Caitlin J. Murphy, Kristin R. Di Bona, Angela R Stermer, Jorine J L P Voss, Rashin Ghaffari, John H. Richburg
Publikováno v:
Reproductive Toxicology. 69:150-158
Exposure of rodents to the Sertoli cell (SC) toxicant mono-(2-ethylhexyl) phthalate (MEHP) has been reported to trigger an infiltration of macrophages into the testis in an age- and species-dependent manner. Here we challenge the hypothesis that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735b481685c4251f11eadb1b5c87c2fd
https://doi.org/10.1016/j.reprotox.2017.02.013
https://doi.org/10.1016/j.reprotox.2017.02.013
Publikováno v:
Biol Reprod
Histone three lysine four dimethylation (H3k4me2) in sperm is conserved across species and is linked to transgenerational epigenetic inheritance. To test whether H3K4me2 is a target for transgenerational inheritance of toxicity, a daily gavage bolus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3080286a812d9a4fa6e12ea055608f1b
https://pubmed.ncbi.nlm.nih.gov/31426087
https://pubmed.ncbi.nlm.nih.gov/31426087
Autor:
Kristin R. Di Bona, John H. Richburg, Caitlin J. Murphy, Angela R Stermer, Lydia E. Matesic, Jessica L. Myers
Publikováno v:
Experimental Biology and Medicine. 241:367-374
Major progress in deciphering the role of the E3 ligase, ITCH, in animal physiology has come from the generation and identification of Itch loss-of-function mutant mice ( itchy). Mutant mice display an autoimmune-like phenotype characterized by chron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76b04514bc4634d3196307ccb82e11b8
https://doi.org/10.1177/1535370215610656
https://doi.org/10.1177/1535370215610656
Autor:
Enrica Bianchi, Angela R Stermer, Kathleen Hwang, Edward Dere, Mark Sigman, Gerardo Reyes, Kim Boekelheide, Susan J. Hall
Publikováno v:
Andrology. 6(2)
Sperm RNA is a sensitive monitoring endpoint for male reproductive toxicants, and a potential biomarker to assess male infertility and sperm quality. However, isolation of sperm RNA is a challenging procedure due to the heterogeneous population of ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e15a3d790a5005c82987665603b87d
https://pubmed.ncbi.nlm.nih.gov/29470852
https://pubmed.ncbi.nlm.nih.gov/29470852
Publikováno v:
The Journal of Immunology. 200:102.5-102.5
The testis is an immune-privileged organ that maintains an immune suppressive environment. We have previously shown that exposure of postnatal day (PND) 28 Fischer rats to an acute dose of the Sertoli cell toxicant MEHP leads to an accumulation of CD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2cbe28ae76c8fc6149320b432f560a
https://doi.org/10.4049/jimmunol.200.supp.102.5
https://doi.org/10.4049/jimmunol.200.supp.102.5
Publikováno v:
Biology of Reproduction. 91
The mechanism by which noninfectious testicular inflammation results in infertility is poorly understood. Here the infiltration of CD11b+ immunoreactive testicular interstitial cells (neutrophil, macrophages, dendritic cells) in immature (Postnatal D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99a8e9783b15e07ace65b49872da1ed7
https://doi.org/10.1095/biolreprod.113.115527
https://doi.org/10.1095/biolreprod.113.115527