Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Angela R McLean"'
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 3, p e1006028 (2018)
Although antiretroviral drug therapy suppresses human immunodeficiency virus-type 1 (HIV-1) to undetectable levels in the blood of treated individuals, reservoirs of replication competent HIV-1 endure. Upon cessation of antiretroviral therapy, the re
Externí odkaz:
https://doaj.org/article/3ca9feab25ce47368577f935879c667c
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 9, Pp 22364-22376 (2010)
Many zoonotic, novel infectious diseases in humans appear as sporadic infections with spatially and temporally restricted outbreaks, as seen with influenza A(H5N1). Adaptation is often a key factor for successfully establishing sustained human-to-hum
Externí odkaz:
https://doaj.org/article/33da0d48d324406393243e4729f3e602
Autor:
Hannah E Roberts, Jacob Hurst, Nicola Robinson, Helen Brown, Peter Flanagan, Laura Vass, Sarah Fidler, Jonathan Weber, Abdel Babiker, Rodney E Phillips, Angela R McLean, John Frater, SPARTAC trial investigators
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004914 (2015)
The existence of viral variants that escape from the selection pressures imposed by cytotoxic T-lymphocytes (CTLs) in HIV-1 infection is well documented, but it is unclear when they arise, with reported measures of the time to escape in individuals r
Externí odkaz:
https://doaj.org/article/fb909ad37e3f4906b5258b1013251d66
Autor:
Ruben J Kubiak, Angela R McLean
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30223 (2012)
The "Swine flu" pandemic of 2009 caused world-wide infections and deaths. Early efforts to understand its rate of spread were used to predict the probable future number of cases, but by the end of 2009 it was clear that these predictions had substant
Externí odkaz:
https://doaj.org/article/6845184c27364be585741cba5917adc3
Autor:
Helen R Fryer, Angela R McLean
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 12, p e1002289 (2011)
Because cytotoxic T-lymphocytes (CTLs) have been shown to play a role in controlling human immunodeficiency virus (HIV) infection and because CTL-based simian immunodeficiency virus (SIV) vaccines have proved effective in non-human primates, one goal
Externí odkaz:
https://doaj.org/article/a1ee62189ebc4c4782e727b4fb92e744
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 4, p e1002026 (2011)
We present a method to measure the relative transmissibility ("transmission fitness") of one strain of a pathogen compared to another. The model is applied to data from "competitive mixtures" experiments in which animals are co-infected with a mixtur
Externí odkaz:
https://doaj.org/article/59dfb6ad4dbd48e1bbed3d1962edfcbb
Autor:
Helen R Fryer, Angela R McLean
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23664 (2011)
Understanding the circumstances under which exposure to transmissible spongiform encephalopathies (TSEs) leads to infection is important for managing risks to public health. Based upon ideas in toxicology and radiology, it is plausible that exposure
Externí odkaz:
https://doaj.org/article/8ea30794379e4b46b2bc8a4ca702fae9
Autor:
Helen R Fryer, John Frater, Anna Duda, Mick G Roberts, SPARTAC Trial Investigators, Rodney E Phillips, Angela R McLean
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001196 (2010)
During infection with human immunodeficiency virus (HIV), immune pressure from cytotoxic T-lymphocytes (CTLs) selects for viral mutants that confer escape from CTL recognition. These escape variants can be transmitted between individuals where, depen
Externí odkaz:
https://doaj.org/article/98bae1164c074097b19e006d6645ab7c
Publikováno v:
PLoS Biology, Vol 4, Iss 4, p e90 (2006)
Understanding the role of cytotoxic T lymphocytes (CTLs) in controlling HIV-1 infection is vital for vaccine design. However, it is difficult to assess the importance of CTLs in natural infection. Different human leukocyte antigen (HLA) class I allel
Externí odkaz:
https://doaj.org/article/e5f5662136b641408f6e3e5cf6c43e72
Autor:
Robert May, Angela R. McLean
Robert May's seminal book has played a central role in the development of ecological science. Originally published in 1976, this influential text has overseen the transition of ecology from an observational and descriptive subject to one with a solid
