Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Angela Queisser"'
Autor:
Pascal Brouillard, Matthieu J. Schlögel, Nassim Homayun Sepehr, Raphaël Helaers, Angela Queisser, Elodie Fastré, Simon Boutry, Sandra Schmitz, Philippe Clapuyt, Frank Hammer, Anne Dompmartin, Annamaria Weitz-Tuoretmaa, Jussi Laranne, Louise Pasquesoone, Catheline Vilain, Laurence M. Boon, Miikka Vikkula
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-12 (2021)
Abstract Background Theragnostic management, treatment according to precise pathological molecular targets, requests to unravel patients’ genotypes. We used targeted next-generation sequencing (NGS) or digital droplet polymerase chain reaction (ddP
Externí odkaz:
https://doaj.org/article/3222fedb0916439490030c10e72aa9b4
Autor:
Sven Perner, Jutta Kirfel, David Adler, Maria A. Svensson, Stefan Duensing, Peter Brossart, Ove Andrén, Jessica Carlsson, Ignacija Vlasic, Elisabeth Sievers, Wenzel Vogel, Axel S. Merseburger, Isabella Syring, Christine Sanders, Angela Queisser, Mario Deng, Diana Böhm, Anne von Mässenhausen, Anne Offermann, Niklas Klümper, Johannes Brägelmann
Purpose:The Mediator complex is a multiprotein assembly, which serves as a hub for diverse signaling pathways to regulate gene expression. Because gene expression is frequently altered in cancer, a systematic understanding of the Mediator complex in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90bc946a951ea14ec379f66aa326524f
https://doi.org/10.1158/1078-0432.c.6525383.v1
https://doi.org/10.1158/1078-0432.c.6525383.v1
Autor:
Sven Perner, Jutta Kirfel, David Adler, Maria A. Svensson, Stefan Duensing, Peter Brossart, Ove Andrén, Jessica Carlsson, Ignacija Vlasic, Elisabeth Sievers, Wenzel Vogel, Axel S. Merseburger, Isabella Syring, Christine Sanders, Angela Queisser, Mario Deng, Diana Böhm, Anne von Mässenhausen, Anne Offermann, Niklas Klümper, Johannes Brägelmann
Supplementary Data from Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d8f017ad7a804a24bc8304a8f44fe0
https://doi.org/10.1158/1078-0432.22463369
https://doi.org/10.1158/1078-0432.22463369
Publikováno v:
Circulation Research. 129:155-173
Vascular and lymphatic malformations represent a challenge for clinicians. The identification of inherited and somatic mutations in important signaling pathways, including the PI3K (phosphoinositide 3-kinase)/AKT (protein kinase B)/mTOR (mammalian ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79070c89639a4c5aaaa859e9f8895368
https://doi.org/10.1161/circresaha.121.318145
https://doi.org/10.1161/circresaha.121.318145
Publikováno v:
Otolaryngologic Clinics of North America, Vol. 51, no. 1, p. 41-53 (2018)
The detection of somatic, activating genetic mutations to underlie development of vascular tumors and malformations led to a better understanding of their pathophysiology. Proteins encoded by the detected mutated genes activate the two major signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44d3d24a7abdb6a73fbb498d79d7549
https://doi.org/10.1016/j.otc.2017.09.006
https://doi.org/10.1016/j.otc.2017.09.006
Autor:
Michael Majores, Stefan Müller, Jörg Ellinger, Angela Queisser, Johannes Brägelmann, Wenzel Vogel, Glen Kristiansen, Diana Boehm, Zaki Shaikhibrahim, Niklas Klümper, Anne von Mässenhausen, Anne Schindler, Isabella Syring, Mario C. Deng, Sven Perner, Anne Offermann, Doris Schmidt, Martin Braun
Publikováno v:
Oncotarget
The Mediator complex is a key regulator of gene transcription and several studies demonstrated altered expressions of particular subunits in diverse human diseases, especially cancer. However a systematic study deciphering the transcriptional express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449673f67d5029a113b0e30fdece0070
http://europepmc.org/articles/PMC5029609
http://europepmc.org/articles/PMC5029609
Autor:
Diana Böhm, Sven Perner, Axel S. Merseburger, Elisabeth Sievers, Angela Queisser, Jessica Carlsson, Christine Sanders, Isabella Syring, Ignacija Vlasic, Maria A. Svensson, Wenzel Vogel, Johannes Brägelmann, Niklas Klümper, Anne von Mässenhausen, Mario C. Deng, Anne Offermann, Peter Brossart, Zaki Shaikhibrahim, Ove Andrén, Jutta Kirfel, Stefan Duensing
Purpose: The Mediator complex is a multiprotein assembly, which serves as a hub for diverse signaling pathways to regulate gene expression. Because gene expression is frequently altered in cancer, a systematic understanding of the Mediator complex in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc748dfdd83ab9f8e0a6c098b9b7dd7
https://doi.org/10.1158/1078-0432.ccr-16-0094
https://doi.org/10.1158/1078-0432.ccr-16-0094
Autor:
Wenzel Vogel, Angela Queisser, Andreas Schröck, Britta Thewes, Anne von Mässenhausen, Sven Perner, Glen Kristiansen, Peter Brossart, Johannes Brägelmann, Jutta Kirfel, Friedrich Bootz, Hannah Billig
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 1; Pages: 7
International Journal of Molecular Sciences, Vol 18, Iss 1, p 7 (2016)
International Journal of Molecular Sciences; Volume 18; Issue 1; Pages: 7
International Journal of Molecular Sciences, Vol 18, Iss 1, p 7 (2016)
Head and neck squamous cell carcinoma (HNSCC) remains a clinical challenge and identification of novel therapeutic targets is necessary. The receptor tyrosine kinase AXL has been implicated in several tumor entities and a selective AXL small molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37dae7e24705562e705726a60fd3436
http://europepmc.org/articles/PMC5297642
http://europepmc.org/articles/PMC5297642
Autor:
Nicolas Wernert, Wenzel Vogel, Glen Kristiansen, Tobias Zellweger, Ove Andrén, Lukas Bubendorf, Maria A. Svensson, Angela Queisser, Kerstin Rüenauver, Jutta Kirfel, Anne Offermann, Diana Boehm, Zaki Shaikhibrahim, Martin Braun, Saskia Biskup, Christian Ruiz, Sven Perner, Roopika Menon
Publikováno v:
International Journal of Cancer. 135:19-26
The mediator complex is an evolutionary conserved key regulator of transcription of protein-coding genes and an integrative hub for diverse signaling pathways. In this study, we investigated whether the mediator subunit MED15 is implicated in castrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64589ce76ef727105c78cfbb4011e358
https://doi.org/10.1002/ijc.28647
https://doi.org/10.1002/ijc.28647
Autor:
Nicole Oberbeckmann, Saskia Biskup, Kerstin Rüenauver, Nicolas Wernert, Wenzel Vogel, Sven Perner, Falko Fend, Diana Boehm, Veit Scheble, Mario C. Deng, Zaki Shaikhibrahim, Anne Offermann, Mark A. Rubin, Angela Queisser, Martin Pfeifer, Roopika Menon, Glen Kristiansen
Publikováno v:
The Journal of Pathology. 231:505-516
Castration-resistant prostate cancer (CRPC) is the most aggressive form of prostate cancer (PCa) and remains a significant therapeutic challenge. The key to the development of novel therapeutic targets for CRPC is to decipher the molecular alteration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a73a794f19a3cea8b00e747f50da7fc
https://doi.org/10.1002/path.4274
https://doi.org/10.1002/path.4274