Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Angela Philippen"'
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Akademický článek
Protein expression analysis of chronic lymphocytic leukemia defines the effect of genetic aberrations and uncovers a correlation of CDK4, P27 and P53 with hierarchical risk
Autor: Dirk Winkler, Christof Schneider, Manuela Zucknick, Daniela Bögelein, Kerstin Schulze, Thorsten Zenz, Julia Mohr, Angela Philippen, Henriette Huber, Andreas Bühler, Annett Habermann, Axel Benner, Hartmut Döhner, Stephan Stilgenbauer, Daniel Mertens
Publikováno v: Haematologica, Vol 95, Iss 11 (2010)
Background Chronic lymphocytic leukemia has a variable clinical course. Genomic aberrations identify prognostic subgroups, pointing towards distinct underlying biological mechanisms that are poorly understood. In particular it remains unclear whether
Externí odkaz: https://doaj.org/article/8e74ebe1ab234edf9221380166cc1d62
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3
The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning
Autor: Harald Saumweber, Man Mohan, Nina Heinl, Robert A. H. White, Rainer Renkawitz, Joerg Leers, Angela Philippen, Imke Bardenhagen, Martin Herold, Marek Bartkuhn, Renate Renkawitz-Pohl
Publikováno v: The EMBO Journal. 26:4203-4214
Insulator sequences guide the function of distantly located enhancer elements to the appropriate target genes by blocking inappropriate interactions. In Drosophila, five different insulator binding proteins have been identified, Zw5, BEAF-32, GAGA fa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b985491555e20fd54e7ba29b26c2f784
https://doi.org/10.1038/sj.emboj.7601851
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5
Chronic lymphocytic leukemia and 13q14: miRs and more
Autor: Nupur Bhattacharya, Thorsten Zenz, Cordula Tschuch, Stephan Wolf, Danilo Allegra, Melanie Ruppel, Daniel Mertens, Stephan Stilgenbauer, Irina Idler, Angela Philippen
Publikováno v: Leukemialymphoma. 50(3)
Loss of a critical region in 13q14.3 [del(13q)] is the most common genomic aberration in chronic lymphocytic leukemia (CLL), occurring in more than 50% of patients (Stilgenbauer et al., Oncogene 1998;16:1891 - 1897, Dohner et al., N Engl J Med 2000;3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9547dc94d96804aab1025aeac39ff5
https://pubmed.ncbi.nlm.nih.gov/19347735
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6
Maturation of the miR15a/miR16-1 Family Is Impaired In Chronic Lymphocytic Leukaemia
Autor: Danilo Allegra, Stephan Stilgenbauer, Hartmut Döhner, Daniel Mertens, Thorsten Zenz, Angela Philippen
Publikováno v: Blood. 116:53-53
Abstract 53 A role as tumor suppressor has been proposed for the miR15a/miR-16-1 family of miRNA genes localized in a critical region in 13q14 that is deleted in more than 50% of CLL patients. These two miRNA genes regulate cell cycle progression and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b597fc497a3c5cdd0b6253e61fd0ff5e
https://doi.org/10.1182/blood.v116.21.53.53
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7
Epimutation of the Tumor Suppressor Mechanism in 13q14.3 Involves Monoallelic Expression, Non-Coding RNA Genes and Deregulation of NFkB Signalling
Autor: Angela Philippen, Hartmut Doehner, Daniel Mertens, Stephan Stilgenbauer, Melanie Ruppel, Peter Lichter, Nupur Bhattacharya, Cordula Tschuch
Publikováno v: Blood. 112:783-783
Deletions in chromosomal band 13q14.3 occur in a variety of human neoplasms like chronic lymphocytic leukaemia (CLL), indicating a tumor suppressor mechanism (TSM) in this region. Intriguingly, several characteristics of the region of interest point
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f9494d5720893d290e15d9b573ebc68
https://doi.org/10.1182/blood.v112.11.783.783
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