Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina

Autor: Andrew C. Kotze, Barney M. Hines, Neil H. Bagnall, Clare A. Anstead, Praveer Gupta, Robert C. Reid, Angela P. Ruffell, David P. Fairlie

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 5, Iss 3, Pp 201-208 (2015)

The Australian sheep blowfly, Lucilia cuprina, is an ecto-parasite that causes significant economic losses in the sheep industry. Emerging resistance to insecticides used to protect sheep from this parasite is driving the search for new drugs that ac

Externí odkaz: https://doaj.org/article/cecbac288ee44d78bf3b75f7ba12170b

Venom composition and bioactive RF-amide peptide toxins of the saddleback caterpillar, Acharia stimulea (Lepidoptera: Limacodidae)

Autor: Mohaddeseh H. Goudarzi, David A. Eagles, Junxian Lim, Kimberley A. Biggs, Andrew C. Kotze, Angela P. Ruffell, David P. Fairlie, Glenn F. King, Andrew A. Walker

Publikováno v: Biochemical Pharmacology. 213:115598

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b58a542fab72d3c96f42cac7ef04e8d
https://doi.org/10.1016/j.bcp.2023.115598

Mutations in the Hco-mptl-1 gene in a field-derived monepantel-resistant isolate of Haemonchus contortus

Autor: Jane Lamb, Timothy P. Elliott, Angela P. Ruffell, Andrew C. Kotze, Ali Raza, Neil H. Bagnall, Peter W. Hunt

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 2, Pp 236-240 (2017)
International Journal for Parasitology: Drugs and Drug Resistance

Resistance to the anthelmintic drug monepantel (Zolvix®) has emerged in parasitic worms infecting sheep and goats. The mechanism of resistance in these cases is unknown. The drug targets nicotinic acetylcholine receptors belonging to the nematode-sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1fe2d2a683627881bbd776e466eada
http://www.sciencedirect.com/science/article/pii/S2211320717300246

Response of drug-susceptible and -resistant Haemonchus contortus larvae to monepantel and abamectin alone or in combination in vitro

Autor: Andrew C. Kotze, Jane Lamb, Angela P. Ruffell, Timothy P. Elliott

Publikováno v: Veterinary parasitology. 249

There is an increasing interest in the use of combination anthelmintic products for the control of intestinal nematode parasites of livestock. These products are seen as attractive options for parasite control in the face of increasing levels of resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b4e120981f171e5f2adb75a11539cb
https://pubmed.ncbi.nlm.nih.gov/29279087

Cloning, recombinant expression and inhibitor profiles of dihydrofolate reductase from the Australian sheep blow fly,Lucilia cuprina

Autor: Roger Pearson, Neil H. Bagnall, Angela P. Ruffell, Andrew C. Kotze

Publikováno v: Medical and Veterinary Entomology. 28:297-306

While dihydrofolate reductase (DHFR) is an important drug target in mammals, bacteria and protozoa, no inhibitors of this enzyme have been developed as commercial insecticides. We therefore examined the potential of this enzyme as a drug target in an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d31038cb4b67abca6912dbfbf25b285f
https://doi.org/10.1111/mve.12041