Variable domain mutational analysis to probe the molecular mechanisms of high viscosity of an IgG1 antibody

Autor: Jing Dai, Saeed Izadi, Jonathan Zarzar, Patrick Wu, Angela Oh, Paul J. Carter

Publikováno v: mAbs, Vol 16, Iss 1 (2024)

ABSTRACTSubcutaneous injection is the preferred route of administration for many antibody therapeutics for reasons that include its speed and convenience. However, the small volume limit (typically [Formula: see text]2 mL) for subcutaneous delivery o

Externí odkaz: https://doaj.org/article/a50ad440254f4b97bb89e51aeaf46a98

Structural basis for resistance to diverse classes of NAMPT inhibitors.

Autor: Weiru Wang, Kristi Elkins, Angela Oh, Yen-Ching Ho, Jiansheng Wu, Hong Li, Yang Xiao, Mandy Kwong, Mary Coons, Bobby Brillantes, Eric Cheng, Lisa Crocker, Peter S Dragovich, Deepak Sampath, Xiaozhang Zheng, Kenneth W Bair, Thomas O'Brien, Lisa D Belmont

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109366 (2014)

Inhibiting NAD biosynthesis by blocking the function of nicotinamide phosphoribosyl transferase (NAMPT) is an attractive therapeutic strategy for targeting tumor metabolism. However, the development of drug resistance commonly limits the efficacy of

Externí odkaz: https://doaj.org/article/bb7aac885fbb499794f3ed2668eeafc5

Dendritic Melanocytic Hyperplasia in Pterygia- A Potential Source of Diagnostic Confusion with Primary Acquired Melanosis

Autor: Angela Oh, Ben Glasgow

Publikováno v: Ocular Oncology and Pathology.

Purpose: To report the nearly ubiquitous prevalence of melanocytic hyperplasia in benign pterygia/pingueculae and establish that is insufficiently recognized. Methods: This is a retrospective immunohistochemical pathology case series of 30 consecutiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::702e320a93e47e29d95aea406f5f2ba4
https://doi.org/10.1159/000530514

Increased ER Stress After Experimental Ischemic Optic Neuropathy and Improved RGC and Oligodendrocyte Survival After Treatment With Chemical Chaperon

Autor: Louise A. Mesentier-Louro, Varun Kumar, Kathleen Heng, Mohammad Ali Shariati, Yaping Joyce Liao, Haoliang Huang, Angela Oh, Yang Hu

Publikováno v: Investigative Ophthalmology & Visual Science

Purpose Increased endoplasmic reticulum (ER) stress is one of the earliest subcellular changes in neuro-ophthalmic diseases. In this study, we investigated the expression of key molecules in the ER stress pathways following nonarteritic anterior isch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a58df3873a3af278a1cb0f608405f67
http://europepmc.org/articles/PMC6735778

Consumers’ Implicit and Explicit Recall, Understanding and Perceptions of Products with Nutrition-Related Messages: An Online Survey

Autor: Beatriz Franco-Arellano, Angela Oh, Mary R. L’Abbé, Lana Vanderlee, Mavra Ahmed

Publikováno v: International Journal of Environmental Research and Public Health
Volume 17
Issue 21
International Journal of Environmental Research and Public Health, Vol 17, Iss 8213, p 8213 (2020)

This study aimed to assess consumers&rsquo
implicit and explicit recall, understanding and perceptions of products with a nutrition claim and a symbol depicting &lsquo
health,&rsquo
and to determine whether these perceptions differed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4504e37517a79a6bcd64c58e09d0f4