Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Angela Mousley"'
Autor:
Luca Golinelli, Ellen Geens, Allister Irvine, Ciaran J. McCoy, Elke Vandewyer, Louise E. Atkinson, Angela Mousley, Liesbet Temmerman, Isabel Beets
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Background The phylum Nematoda is incredibly diverse and includes many parasites of humans, livestock, and plants. Peptide-activated G protein-coupled receptors (GPCRs) are central to the regulation of physiology and numerous behaviors, and
Externí odkaz:
https://doaj.org/article/c2d670455c1b439c9fcacc8998ab993e
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011618 (2023)
Antimicrobial Peptides (AMPs) are key constituents of the invertebrate innate immune system and provide critical protection against microbial threat. Nematodes display diverse life strategies where they are exposed to heterogenous, microbe rich, envi
Externí odkaz:
https://doaj.org/article/0c69fb3f20c247b68de15101389e712b
Autor:
Orawan Phuphisut, Akkarin Poodeepiyasawat, Tippayarat Yoonuan, Dorn Watthanakulpanich, Palang Chotsiri, Onrapak Reamtong, Angela Mousley, Geoffrey N. Gobert, Poom Adisakwattana
Publikováno v:
Parasites & Vectors, Vol 15, Iss 1, Pp 1-18 (2022)
Abstract Background Ascaris lumbricoides causes human ascariasis, the most prevalent helminth disease, infecting approximately 1 billion individuals globally. In 2019 the global disease burden was estimated to be 754,000 DALYs and resulted in 2090 de
Externí odkaz:
https://doaj.org/article/1612e04a6f3443cc80444da1b0ab413f
Autor:
Emily Robb, Erin M McCammick, Duncan Wells, Paul McVeigh, Erica Gardiner, Rebecca Armstrong, Paul McCusker, Angela Mousley, Nathan Clarke, Nikki J Marks, Aaron G Maule
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 11, p e0010854 (2022)
Fasciola spp. liver flukes have significant impacts in veterinary and human medicine. The absence of a vaccine and increasing anthelmintic resistance threaten sustainable control and underscore the need for novel flukicides. Functional genomic approa
Externí odkaz:
https://doaj.org/article/942dd2f73db1407ab6c0e8a48ec46440
Autor:
Bethany A. Crooks, Darrin Mckenzie, Luke C. Cadd, Ciaran J. McCoy, Paul McVeigh, Nikki J. Marks, Aaron G. Maule, Angela Mousley, Louise E. Atkinson
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The endocannabinoid signalling (ECS) system is a complex lipid signalling pathway that modulates diverse physiological processes in both vertebrate and invertebrate systems. In nematodes, knowledge of endocannabinoid (EC) biology is derived primarily
Externí odkaz:
https://doaj.org/article/9c5accc957de4090a4409b0b7fdf9cd0
Autor:
Geoffrey N Gobert, Louise E Atkinson, Andrea Lokko, Tippayarat Yoonuan, Orawan Phuphisut, Akkarin Poodeepiyasawat, Nirundorn Homsuwan, Angela Mousley, Poom Adisakwattana
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 6, p e0010491 (2022)
BackgroundPrevious reports show altered gut bacterial profiles are associated with helminth infected individuals. Our recently published molecular survey of clinical helminthiases in Thailand border regions demonstrated a more comprehensive picture o
Externí odkaz:
https://doaj.org/article/3d66f33d8941403db5ea189729e7a472
Autor:
Paul McCusker, Wasim Hussain, Paul McVeigh, Erin McCammick, Nathan G. Clarke, Emily Robb, Fiona M. McKay, Peter M. Brophy, David J. Timson, Angela Mousley, Nikki J. Marks, Aaron G. Maule
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 14, Iss , Pp 46-55 (2020)
For over a decade RNA interference (RNAi) has been an important molecular tool for functional genomics studies in parasitic flatworms. Despite this, our understanding of RNAi dynamics in many flatworm parasites, such as the temperate liver fluke (Fas
Externí odkaz:
https://doaj.org/article/6adc572dca29437098a0058fa1081fd4
Autor:
Poom Adisakwattana, Tippayarat Yoonuan, Orawan Phuphisut, Akkarin Poodeepiyasawat, Nirundorn Homsuwan, Catherine A. Gordon, Donald P. McManus, Louise E. Atkinson, Angela Mousley, Geoffrey N. Gobert
Publikováno v:
Parasites & Vectors, Vol 13, Iss 1, Pp 1-10 (2020)
Abstract Background Under-regulated national borders in Southeast Asia represent potential regions for enhanced parasitic helminth transmission and present barriers to helminthiasis disease control. Methods Three Thailand border regions close to Myan
Externí odkaz:
https://doaj.org/article/c63a2e5a8d46447792cf6d7f9fb8283e
Autor:
Louise E. Atkinson, Ciaran J. McCoy, Bethany A. Crooks, Fiona M. McKay, Paul McVeigh, Darrin McKenzie, Allister Irvine, John Harrington, Bruce A. Rosa, Makedonka Mitreva, Nikki J. Marks, Aaron G. Maule, Angela Mousley
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Nematode parasites undermine human health and global food security. The frontline anthelmintic portfolio used to treat parasitic nematodes is threatened by the escalation of anthelmintic resistance, resulting in a demand for new drug targets for para
Externí odkaz:
https://doaj.org/article/8a21f17362a64b8da5c79e86ac91e8cd
Autor:
Paul McVeigh, Erin McCammick, Paul McCusker, Duncan Wells, Jane Hodgkinson, Steve Paterson, Angela Mousley, Nikki J. Marks, Aaron G. Maule
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 1, Pp 87-103 (2018)
G protein-coupled receptors (GPCRs) are established drug targets. Despite their considerable appeal as targets for next-generation anthelmintics, poor understanding of their diversity and function in parasitic helminths has thwarted progress towards
Externí odkaz:
https://doaj.org/article/6c49fc116d124b2ca6df6512d296b7ea