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pro vyhledávání: '"Angela Marie Gocher"'
Autor:
Angela Marie Gocher, Jian Cui, Andrea Szymczak-Workman, Kate Vignali, Julianna N Latini, Gwen P Pieklo, Lyndsay Avery, Ellyse L Cipolla, Brydie R Huckestein, Lee Hedden, Marlies Meisel, John F Alcorn, Lawrence P Kane, Creg J. Workman, Dario A. A. Vignali
Publikováno v:
The Journal of Immunology. 208:53.23-53.23
Regulatory T cells (Tregs) are an immunosuppressive cell population that inhibits immune cell function to maintain peripheral tolerance and homeostasis. We have previously shown that Treg-- response to interferon gamma (IFNγ) is required for respons
Publikováno v:
The Journal of Immunology. 204:244.8-244.8
We have shown that murine regulatory T cells (Tregs) produce the cytokine interferon gamma (IFNγ) during anti-PD1 immunotherapy and that IFNγ-driven Treg dysfunction is necessary for tumor clearance by anti-PD1. However, it is unknown how Treg prod