Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells

Autor: Yujian H. Yang, Roman Istomine, Fernando Alvarez, Tho-Alfakar Al-Aubodah, Xiang Qun Shi, Tomoko Takano, Angela M. Thornton, Ethan M. Shevach, Ji Zhang, Ciriaco A. Piccirillo

Publikováno v: Cell Reports, Vol 30, Iss 5, Pp 1515-1529.e4 (2020)

Summary: Regulatory T (Treg) cells integrate diverse environmental signals to modulate their function for optimal suppression. Translational regulation represents a favorable mechanism for Treg cell environmental sensing and adaptation. In this study

Externí odkaz: https://doaj.org/article/8b33c085871f449f89fb91c11d935cc7

Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells

Autor: Marie-Céline Deau, Angela M. Thornton, Stephanie Gras, Leif Carlsson, Vincent Mittelheisser, Susan Chan, Giovanni Cova, Peggy Kirstetter, Chiara Taroni, Bernard Jost, Ethan M. Shevach, Marie Cerciat, Matthieu Jung, Christelle Thibault-Carpentier, Qi Cai, Philippe Kastner, Muriel Philipps

Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, 2021, 218 (10), pp.e20202317. ⟨10.1084/jem.20202317⟩
Journal of Experimental Medicine, Rockefeller University Press, 2021, 218 (10), ⟨10.1084/jem.20202317⟩

International audience; Our understanding of cell fate decisions in hematopoietic stem cells is incomplete. Here, we show that the transcription factor Helios is highly expressed in murine hematopoietic stem and progenitor cells (HSPCs), where it is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa67fa174402716bd69ba0708bdaf889
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-189179

Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3

Autor: Yujian H, Yang, Roman, Istomine, Fernando, Alvarez, Tho-Alfakar, Al-Aubodah, Xiang Qun, Shi, Tomoko, Takano, Angela M, Thornton, Ethan M, Shevach, Ji, Zhang, Ciriaco A, Piccirillo

Publikováno v: Cell reports. 30(5)

Regulatory T (Treg) cells integrate diverse environmental signals to modulate their function for optimal suppression. Translational regulation represents a favorable mechanism for Treg cell environmental sensing and adaptation. In this study, we carr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4572871a118d6b31736949afeb154be
https://pubmed.ncbi.nlm.nih.gov/32023466

Helios expression in CD4+Foxp3− T cells

Autor: Kole Tison, Vinay Penna, Mathias Skadow, Cihan Oguz, Justin Lack, Angela M Thornton, Ethan M Shevach

Publikováno v: The Journal of Immunology. 206:51.15-51.15

The transcription factor Helios is expressed in the majority of Foxp3+ Treg cells, where it is necessary for the maintenance of self-tolerance. Mice with a Foxp3-specific deficiency in Helios develop systemic immune activation with increased T follic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57a6c08e578deb80a44d74dc63786fca
https://doi.org/10.4049/jimmunol.206.supp.51.15

Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells

Autor: Tho-Alfakar Al-Aubodah, Ethan M. Shevach, Xiang Qun Shi, Ji Zhang, Ciriaco A. Piccirillo, Angela M. Thornton, Yujian H. Yang, Roman Istomine, Tomoko Takano, Fernando Alvarez

Publikováno v: Cell Reports, Vol 30, Iss 5, Pp 1515-1529.e4 (2020)

Summary: Regulatory T (Treg) cells integrate diverse environmental signals to modulate their function for optimal suppression. Translational regulation represents a favorable mechanism for Treg cell environmental sensing and adaptation. In this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a0522d597338d110dcf08196b8d9af
https://doi.org/10.1016/j.celrep.2020.01.002