Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Angela M. Jarrett"'
Autor:
Jianchen Yang, Jack Virostko, Junyan Liu, Angela M. Jarrett, David A. Hormuth, Thomas E. Yankeelov
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Glucose plays a central role in tumor metabolism and development and is a target for novel therapeutics. To characterize the response of cancer cells to blockade of glucose uptake, we collected time-resolved microscopy data to track the grow
Externí odkaz:
https://doaj.org/article/df4fe1d9799942a9801f98eb223ad66c
Autor:
John Virostko, Anna G. Sorace, Kalina P. Slavkova, Anum S. Kazerouni, Angela M. Jarrett, Julie C. DiCarlo, Stefanie Woodard, Sarah Avery, Boone Goodgame, Debra Patt, Thomas E. Yankeelov
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-12 (2021)
Abstract Background The purpose of this study was to determine whether advanced quantitative magnetic resonance imaging (MRI) can be deployed outside of large, research-oriented academic hospitals and into community care settings to predict eventual
Externí odkaz:
https://doaj.org/article/82deaf63a0e6424a945d9c5d7d128036
Autor:
Angela M. Jarrett, David A. Hormuth, II, Chengyue Wu, Anum S. Kazerouni, David A. Ekrut, John Virostko, Anna G. Sorace, Julie C. DiCarlo, Jeanne Kowalski, Debra Patt, Boone Goodgame, Sarah Avery, Thomas E. Yankeelov
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 820-830 (2020)
The ability to accurately predict response and then rigorously optimize a therapeutic regimen on a patient-specific basis, would transform oncology. Toward this end, we have developed an experimental-mathematical framework that integrates quantitativ
Externí odkaz:
https://doaj.org/article/17a79e5efe4e466a8d55e196250c77f9
Autor:
Angela M. Jarrett, David A. Hormuth, Vikram Adhikarla, Prativa Sahoo, Daniel Abler, Lusine Tumyan, Daniel Schmolze, Joanne Mortimer, Russell C. Rockne, Thomas E. Yankeelov
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract While targeted therapies exist for human epidermal growth factor receptor 2 positive (HER2 +) breast cancer, HER2 + patients do not always respond to therapy. We present the results of utilizing a biophysical mathematical model to predict tu
Externí odkaz:
https://doaj.org/article/b0d9d0ed140743fbab8a82a362ac28df
Autor:
Meghan J. Bloom, Angela M. Jarrett, Todd A. Triplett, Anum K. Syed, Tessa Davis, Thomas E. Yankeelov, Anna G. Sorace
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Therapy targeted to the human epidermal growth factor receptor type 2 (HER2) is used in combination with cytotoxic therapy in treatment of HER2+ breast cancer. Trastuzumab, a monoclonal antibody that targets HER2, has been shown p
Externí odkaz:
https://doaj.org/article/e4b25aa93b244549ae202f5975b1e3d2
Publikováno v:
Radiation Oncology, Vol 15, Iss 1, Pp 1-14 (2020)
Abstract Background Intra-and inter-tumoral heterogeneity in growth dynamics and vascularity influence tumor response to radiation therapy. Quantitative imaging techniques capture these dynamics non-invasively, and these data can initialize and const
Externí odkaz:
https://doaj.org/article/0f7be69821454086b3d9acdded03ab10
Autor:
Anum S. Kazerouni, Manasa Gadde, Andrea Gardner, David A. Hormuth, II, Angela M. Jarrett, Kaitlyn E. Johnson, Ernesto A.B. F. Lima, Guillermo Lorenzo, Caleb Phillips, Amy Brock, Thomas E. Yankeelov
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101807- (2020)
Summary: We provide an overview on the use of biological assays to calibrate and initialize mechanism-based models of cancer phenomena. Although artificial intelligence methods currently dominate the landscape in computational oncology, mathematical
Externí odkaz:
https://doaj.org/article/117782a5120f4037a605eb88706cb82b
Autor:
Zicheng Hu, Yu Li, Annemarie Van Nieuwenhuijze, Hilary J. Selden, Angela M. Jarrett, Anna G. Sorace, Thomas E. Yankeelov, Adrian Liston, Lauren I.R. Ehrlich
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 168-180 (2017)
Upon recognition of auto-antigens, thymocytes are negatively selected or diverted to a regulatory T cell (Treg) fate. CCR7 is required for negative selection of auto-reactive thymocytes in the thymic medulla. Here, we describe an unanticipated contri
Externí odkaz:
https://doaj.org/article/25d11f79f27b4d3fbca6883e6c7e9b5c
Autor:
Julie C. DiCarlo, Angela M. Jarrett, Anum S. Kazerouni, John Virostko, Anna Sorace, Kalina P. Slavkova, Stefanie Woodard, Sarah Avery, Debra Patt, Boone Goodgame, Thomas E. Yankeelov
Publikováno v:
Magnetic Resonance in Medicine. 89:1134-1150
A method is presented to select the optimal time points at which to measure DCE-MRI signal intensities, leaving time in the MR exam for high-spatial resolution image acquisition.Simplicial complexes are generated from the Kety-Tofts model pharmacokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0469b7b25cc64068d16a394335895c30
https://doi.org/10.1002/mrm.29511
https://doi.org/10.1002/mrm.29511
Autor:
Chengyue Wu, David A. Hormuth, Guillermo Lorenzo, Angela M. Jarrett, Federico Pineda, Frederick M. Howard, Gregory S. Karczmar, Thomas E. Yankeelov
Publikováno v:
IEEE Transactions on Biomedical Engineering
This study establishes a fluid dynamics model personalized with patient-specific imaging data to optimize neoadjuvant therapy (i.e., doxorubicin) protocols for breast cancers.Ten patients recruited at the University of Chicago were included in this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566e9ccfb318cfb2005e1ebde3b3c3e5
https://doi.org/10.1109/tbme.2022.3168402
https://doi.org/10.1109/tbme.2022.3168402