Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Angela M. Gocher-Demske"'
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101890- (2022)
Summary: Signaling cascades can act in series or in parallel. Here, we describe a convenient and robust protocol for dual, sequential knockdown of two proteins using RNA interference. We detail the steps for a quantitative mapping of signaling circui
Externí odkaz:
https://doaj.org/article/d2083cabe06041da9be3259bc9b61e09
Autor:
Angela M. Gocher-Demske, Jian Cui, Andrea L. Szymczak-Workman, Kate M. Vignali, Julianna N. Latini, Gwen P. Pieklo, Jesse C. Kimball, Lyndsay Avery, Ellyse M. Cipolla, Brydie R. Huckestein, Lee Hedden, Marlies Meisel, John F. Alcorn, Lawrence P. Kane, Creg J. Workman, Dario A. A. Vignali
Publikováno v:
Nat Immunol
Regulatory T (T(reg)) cells are an immunosuppressive population that are required to maintain peripheral tolerance and prevent tissue damage from immunopathology, via anti-inflammatory cytokines, inhibitor receptors and metabolic disruption. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317856fa71787b2cd7f75b69af66d144
https://doi.org/10.1038/s41590-023-01453-w
https://doi.org/10.1038/s41590-023-01453-w
Publikováno v:
Nat Immunol
The binding of PD-L1 to CD80 on antigen-presenting cells prevents PD-1 ligation on T cells. Therapeutic blockade of the cis-PD-L1–CD80 interaction liberates PD-L1 to bind to PD-1, inhibits autoreactive T cells and robustly alleviates autoimmune sym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531b27bb370445c0349e1b99746d6f72
https://doi.org/10.1038/s41590-022-01140-2
https://doi.org/10.1038/s41590-022-01140-2
Autor:
Mackenzie J. Bender, Alex C. McPherson, Catherine M. Phelps, Surya P. Pandey, Colin R. Laughlin, Jake H. Shapira, Luzmariel Medina Sanchez, Mohit Rana, Tanner G. Richie, Tahliyah S. Mims, Angela M. Gocher-Demske, Luisa Cervantes-Barragan, Steven J. Mullett, Stacy L. Gelhaus, Tullia C. Bruno, Nikki Cannon, John A. McCulloch, Dario A.A. Vignali, Reinhard Hinterleitner, Alok V. Joglekar, Joseph F. Pierre, Sonny T.M. Lee, Diwakar Davar, Hassane M. Zarour, Marlies Meisel
Publikováno v:
Cell. 186:1846-1862.e26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c602601337b3b15471cb1ee257b9d43
https://doi.org/10.1016/j.cell.2023.03.011
https://doi.org/10.1016/j.cell.2023.03.011