Zobrazeno 1 - 10
of 570
pro vyhledávání: '"Angela M. Christiano"'
Autor:
Yask Gupta, Anna Lara Ernst, Artem Vorobyev, Foteini Beltsiou, Detlef Zillikens, Katja Bieber, Simone Sanna-Cherchi, Angela M. Christiano, Christian D. Sadik, Ralf J. Ludwig, Tanya Sezin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
In this study, 591 mice from an advanced-intercross mouse line were used to provide evidence that fungi are regulated by host genetics, while uncovering a regulatory role of diet on the composition of fungi in the murine gut.
Externí odkaz:
https://doaj.org/article/f9d4b29bc4eb41828406e434b6057330
Autor:
Stephanie O. Erjavec, Sahar Gelfman, Alexa R. Abdelaziz, Eunice Y. Lee, Isha Monga, Anna Alkelai, Iuliana Ionita-Laza, Lynn Petukhova, Angela M. Christiano
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Common variants have been discovered to be associated with Alopecia Areata; however, rare variants have been less well studied. Here, the authors use whole-exome sequencing to identify associated rare variants in the hair keratin gene KRT82. Further,
Externí odkaz:
https://doaj.org/article/58936acbeeb64f05a18c9a9185f31d6c
Autor:
Zhenpeng Dai, Tanya Sezin, Yuqian Chang, Eunice Y. Lee, Eddy Hsi Chun Wang, Angela M. Christiano
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Alopecia areata (AA) is an autoimmune disease caused by T cell-mediated destruction of the hair follicle (HF). Therefore, approaches that effectively disrupt pathogenic T cell responses are predicted to have therapeutic benefit for AA treatment. T ce
Externí odkaz:
https://doaj.org/article/06ceda2989ab47ce85b4bd591af68703
Autor:
Hideyuki Ujiie, David Rosmarin, Michael P. Schön, Sonja Ständer, Katharina Boch, Martin Metz, Marcus Maurer, Diamant Thaci, Enno Schmidt, Connor Cole, Kyle T. Amber, Dario Didona, Michael Hertl, Andreas Recke, Hanna Graßhoff, Alexander Hackel, Anja Schumann, Gabriela Riemekasten, Katja Bieber, Gant Sprow, Joshua Dan, Detlef Zillikens, Tanya Sezin, Angela M. Christiano, Kerstin Wolk, Robert Sabat, Khalaf Kridin, Victoria P. Werth, Ralf J. Ludwig
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
An estimated 20–25% of the population is affected by chronic, non-communicable inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most frequent chronic inflammatory skin diseases are atopic dermatitis, psoriasis, urtic
Externí odkaz:
https://doaj.org/article/b4d49925740d40d997ea17caa001b46a
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4751-4758 (2021)
Not all therapeutics are created equal in regards to individual patients. The problem of identifying which compound will work best with which patient is a significant burden across all disease contexts. In the context of autoimmune diseases such as a
Externí odkaz:
https://doaj.org/article/5c88013cf3bd432f9b7a8c61e1e53e88
Autor:
Catherine Do, Emmanuel L. P. Dumont, Martha Salas, Angelica Castano, Huthayfa Mujahed, Leonel Maldonado, Arunjot Singh, Sonia C. DaSilva-Arnold, Govind Bhagat, Soren Lehman, Angela M. Christiano, Subha Madhavan, Peter L. Nagy, Peter H. R. Green, Rena Feinman, Cornelia Trimble, Nicholas P. Illsley, Karen Marder, Lawrence Honig, Catherine Monk, Andre Goy, Kar Chow, Samuel Goldlust, George Kaptain, David Siegel, Benjamin Tycko
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-39 (2020)
Abstract Background Mapping of allele-specific DNA methylation (ASM) can be a post-GWAS strategy for localizing regulatory sequence polymorphisms (rSNPs). The advantages of this approach, and the mechanisms underlying ASM in normal and neoplastic cel
Externí odkaz:
https://doaj.org/article/5eb3ee3f1c404b03b00592b77756c21c
Autor:
Zongyou Guo, Chi‐Kun Tong, Joanna Jacków, Yanne S. Doucet, Hasan E. Abaci, Wangyong Zeng, Corey Hansen, Ryota Hayashi, Dominick DeLorenzo, Avina Rami, Alberto Pappalardo, Ellen A. Lumpkin, Angela M. Christiano
Publikováno v:
Bioengineering & Translational Medicine, Vol 7, Iss 1, Pp n/a-n/a (2022)
Abstract Atopic dermatitis (AD), driven by interleukins (IL‐4/IL‐13), is a chronic inflammatory skin disease characterized by intensive pruritus. However, it is unclear how immune signaling and sensory response pathways cross talk with each other
Externí odkaz:
https://doaj.org/article/e02dbcb9a03e4f028a42af44b195894e
Autor:
Hasan Erbil Abaci, Abigail Coffman, Yanne Doucet, James Chen, Joanna Jacków, Etienne Wang, Zongyou Guo, Jung U. Shin, Colin A. Jahoda, Angela M. Christiano
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Human skin constructs hold potential for regenerative medicine, but the incorporation of hair follicles into such constructs is a challenge. Here, the authors use 3D printed molds to pattern hair follicle cell types in a physiological organization, a
Externí odkaz:
https://doaj.org/article/58390131d3fc465c8beb113b90dc07a2
Publikováno v:
JCI Insight, Vol 6, Iss 7 (2021)
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) are key intracellular mediators in the signal transduction of many cytokines and growth factors. Common γ chain cytokines and interferon-γ that use the JAK/STAT pathway
Externí odkaz:
https://doaj.org/article/f9b08b7851c048cc82310571d593c4c0
Autor:
Ali Jabbari, Jane E. Cerise, James C. Chen, Julian Mackay-Wiggan, Madeleine Duvic, Vera Price, Maria Hordinsky, David Norris, Raphael Clynes, Angela M. Christiano
Publikováno v:
EBioMedicine, Vol 7, Iss C, Pp 240-247 (2016)
Alopecia areata (AA) is an autoimmune disease typified by nonscarring hair loss with a variable clinical course. In this study, we conducted whole genome gene expression analysis of 96 human scalp skin biopsy specimens from AA or normal control subje
Externí odkaz:
https://doaj.org/article/0fc219e55d03415f861643f4a0e52000