Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Angela M Yu"'
Autor:
Lihua Shi, Zhe Zhang, Angela M Yu, Wei Wang, Zhi Wei, Ehtisham Akhter, Kelly Maurer, Patrícia Costa Reis, Li Song, Michelle Petri, Kathleen E Sullivan
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e93846 (2014)
Gene expression studies of peripheral blood mononuclear cells from patients with systemic lupus erythematosus (SLE) have demonstrated a type I interferon signature and increased expression of inflammatory cytokine genes. Studies of patients with Aica
Externí odkaz:
https://doaj.org/article/bb2c653ce9fa455a8ba4b735e59379fb
Autor:
Liang Liu, Angela M Yu, Xiuye Wang, Lindsey V. Soles, Yiling Chen, Yoseop Yoon, Kristianna S.K. Sarkan, Marielle Cárdenas Valdez, Johannes Linder, Ivan Marazzi, Zhaoxia Yu, Feng Qiao, Wei Li, Georg Seelig, Yongsheng Shi
Publikováno v:
bioRxiv
JTE-607 is a small molecule compound with anti-inflammation and anti-cancer activities. Upon entering the cell, it is hydrolyzed to Compound 2, which directly binds to and inhibits CPSF73, the endonuclease for the cleavage step in pre-mRNA 3′ proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7673b4aecc8ad486eea8b9225af718a8
https://europepmc.org/articles/PMC10120630/
https://europepmc.org/articles/PMC10120630/
Publikováno v:
Nucleic acids research. 50(21)
RNA folds cotranscriptionally to traverse out-of-equilibrium intermediate structures that are important for RNA function in the context of gene regulation. To investigate this process, here we study the structure and function of the Bacillus subtilis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204a957449ee8c33461fb05db8fce32d
https://pubmed.ncbi.nlm.nih.gov/35348734
https://pubmed.ncbi.nlm.nih.gov/35348734
Publikováno v:
Bioinformatics
MotivationRNA molecules can undergo complex structural dynamics, especially during transcription, which influence their biological functions. Recently developed high-throughput chemical probing experiments study RNA cotranscriptional folding to gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4e317f466272b9fa436fffe9b71daf
http://europepmc.org/articles/PMC6954663
http://europepmc.org/articles/PMC6954663
Publikováno v:
Nat Rev Genet
The broad roles of RNA in performing and regulating fundamental life processes are being uncovered at a rapid pace. This has sparked profound questions about how RNA function is enacted through RNA structures that orchestrate processes in the complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1800a36cf3de5f7b5d1015b77cd73b0
https://doi.org/10.1038/s41576-018-0034-x
https://doi.org/10.1038/s41576-018-0034-x
Autor:
Angela M, Yu, Julius B, Lucks
Publikováno v:
Nature structuralmolecular biology. 26(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f1f42414d7f3d4bbb8c6d644f0ba7720
https://pubmed.ncbi.nlm.nih.gov/30936529
https://pubmed.ncbi.nlm.nih.gov/30936529
Autor:
Angela M Yu, Lien B. Lai, Julius B. Lucks, Luyi Cheng, Simi Kaur, Alan A. Chen, Paul M. Gasper, Venkat Gopalan
Publikováno v:
Mol Cell
Summary The series of RNA folding events that occur during transcription can critically influence cellular RNA function. Here, we present reconstructing RNA dynamics from data (R2D2), a method to uncover details of cotranscriptional RNA folding. We m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324ea4aa8d0ba0002f6b460c5ef378e2
https://doi.org/10.1016/j.molcel.2020.12.017
https://doi.org/10.1016/j.molcel.2020.12.017
Publikováno v:
Nature structural & molecular biology
RNAs can begin to fold immediately as they emerge from RNA polymerase. During cotranscriptional folding, interactions between nascent RNAs and ligands are able to direct the formation of alternative RNA structures, a feature exploited by noncoding RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8bc77a24e1804bdf07334f6d23ac1ce
https://doi.org/10.1038/nsmb.3316
https://doi.org/10.1038/nsmb.3316
SummaryThe series of RNA folding events that occur during transcription, or a cotranscriptional folding pathway, can critically influence the functional roles of RNA in the cell. Here we present a method, Reconstructing RNA Dynamics from Data (R2D2),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4b697c384b175fd9a79ed5648fd04f
Chemical probing experiments interrogate RNA structures by creating covalent adducts on RNA molecules in structure-dependent patterns. Adduct positions are then detected through conversion of the modified RNAs into complementary DNA (cDNA) by reverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b505c1e088b0d7a90d5ed8670b5474a3
https://doi.org/10.1101/292532
https://doi.org/10.1101/292532