Zobrazeno 1 - 10
of 602
pro vyhledávání: '"Angela M Gronenborn"'
Autor:
Xin Meng, Gongpu Zhao, Ernest Yufenyuy, Danxia Ke, Jiying Ning, Maria Delucia, Jinwoo Ahn, Angela M Gronenborn, Christopher Aiken, Peijun Zhang
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002886 (2012)
During retrovirus particle maturation, the assembled Gag polyprotein is cleaved by the viral protease into matrix (MA), capsid (CA), and nucleocapsid (NC) proteins. To form the mature viral capsid, CA rearranges, resulting in a lattice composed of he
Externí odkaz:
https://doaj.org/article/4ba7f10758c64024af642a710629eb87
Autor:
Gongpu Zhao, Danxia Ke, Thomas Vu, Jinwoo Ahn, Vaibhav B Shah, Ruifeng Yang, Christopher Aiken, Lisa M Charlton, Angela M Gronenborn, Peijun Zhang
Publikováno v:
PLoS Pathogens, Vol 7, Iss 3, p e1002009 (2011)
TRIM proteins play important roles in the innate immune defense against retroviral infection, including human immunodeficiency virus type-1 (HIV-1). Rhesus macaque TRIM5α (TRIM5α(rh)) targets the HIV-1 capsid and blocks infection at an early post-e
Externí odkaz:
https://doaj.org/article/fdf7626b6bc34083ba2352640dadd6bb
Autor:
Khanh K Dao, Angel L Pey, Anja Underhaug Gjerde, Knut Teigen, In-Ja L Byeon, Stein O Døskeland, Angela M Gronenborn, Aurora Martinez
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17602 (2011)
BackgroundThe regulatory subunit (R) of cAMP-dependent protein kinase (PKA) is a modular flexible protein that responds with large conformational changes to the binding of the effector cAMP. Considering its highly dynamic nature, the protein is rathe
Externí odkaz:
https://doaj.org/article/31c7d72bd67e4781abe6317a5e2de01e
Autor:
Sucharita Sarkar, Kaneil K. Zadrozny, Roman Zadorozhnyi, Ryan W. Russell, Caitlin M. Quinn, Alex Kleinpeter, Sherimay Ablan, Hamed Meshkin, Juan R. Perilla, Eric O. Freed, Barbie K. Ganser-Pornillos, Owen Pornillos, Angela M. Gronenborn, Tatyana Polenova
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
HIV maturation inhibitors such as bevirimat (BVM) interfering with Gag processing are emerging as alternative anti-retroviral drug candidates. Here, the authors report structures of assemblies of HIV-1 Gag fragments spanning the CA C-terminal domain
Externí odkaz:
https://doaj.org/article/cbb35289f9cb46858a493c1534ae911c
Autor:
Chunting Zhang, Changmiao Guo, Ryan W. Russell, Caitlin M. Quinn, Mingyue Li, John C. Williams, Angela M. Gronenborn, Tatyana Polenova
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
In this work the authors report the structure of nucleotide-free kinesin-1 motor domain (apo-KIF5B) in complex with paclitaxel-stabilized microtubules using magic-angle-spinning (MAS) NMR spectroscopy. The study provides insights into the dynamic cha
Externí odkaz:
https://doaj.org/article/5f467ec8a94a4825aea7f44870602f10
Autor:
Darian Yang, Angela M Gronenborn
Publikováno v:
Journal of the American Chemical Society. 145:4564-4569
Autor:
Manman Lu, Dmitri Toptygin, Yufei Xiang, Yi Shi, Charles D. Schwieters, Emma C. Lipinski, Jinwoo Ahn, In-Ja L. Byeon, Angela M. Gronenborn
Publikováno v:
Journal of the American Chemical Society. 144:10809-10816
Fluorosubstituted tryptophans serve as valuable probes for fluorescence and nuclear magnetic resonance (NMR) studies of proteins. Here, we describe an unusual photoreactivity introduced by replacing the single tryptophan in cyclophilin A with 7-fluor
Autor:
Manas Seal, Wenkai Zhu, Arina Dalaloyan, Akiva Feintuch, Alexey Bogdanov, Veronica Frydman, Xun‐Cheng Su, Angela M. Gronenborn, Daniella Goldfarb
Publikováno v:
Angewandte Chemie International Edition. 62
Publikováno v:
The Journal of Physical Chemistry A. 126:2286-2297
We developed force field parameters for fluorinated, aromatic amino acids enabling molecular dynamics (MD) simulations of fluorinated proteins. These parameters are tailored to the AMBER ff15ipq protein force field and enable the modeling of 4, 5, 6,
Autor:
Angela M. Gronenborn
Publikováno v:
Biophys Rev
As an incoming IUPAB Councilor, I have been asked to write a short commentary describing myself and my career in science. Throughout my scientific life, my interests have evolved from initially trying to understand the physical and chemical propertie