Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Angela M Crawley"'
Autor:
Julian Little, Michaeline McGuinty, Curtis L Cooper, Raphael Saginur, Marc-André Langlois, Erin Collins, Yannick Galipeau, Corey Arnold, Cameron Bosveld, Aliisa Heiskanen, Alexa Keeshan, Kiran Nakka, Khatereh Shir-Mohammadi, Frederic St-Denis-Bissonnette, Laura Tamblyn, Agatha Vranjkovic, Leah C Wood, Ronald Booth, C Arianne Buchan, Angela M Crawley
Publikováno v:
BMJ Open, Vol 12, Iss 9 (2022)
Purpose To investigate the robustness and longevity of SARS-CoV-2 immune responses conferred by natural infection and vaccination among priority populations such as immunocompromised individuals and people with post-acute sequelae of COVID-19 in a pr
Externí odkaz:
https://doaj.org/article/1e287f3c916a4672bc86af3d21d7ade5
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188427 (2017)
The use of interleukin-7 (IL-7) as an immunorestorative therapeutic has proven effective in HIV infection, cancer and bone marrow transplantation. Mediating its activity through membrane-bound IL-7 receptor α (mCD127), IL-7 therapy increases T-cell
Externí odkaz:
https://doaj.org/article/daa649a65063483b9a65ac199f7f8e62
Autor:
Miroslava Cuperlovic-Culf, Steffany A.L. Bennett, Yannick Galipeau, Pauline S. McCluskie, Corey Arnold, Salman Bagheri, Curtis L. Cooper, Marc-André Langlois, Jörg H. Fritz, Ciriaco A. Piccirillo, Angela M. Crawley
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110484- (2024)
Summary: Prevention of negative COVID-19 infection outcomes is associated with the quality of antibody responses, whose variance by age and sex is poorly understood. Network approaches identified sex and age effects in antibody responses and neutrali
Externí odkaz:
https://doaj.org/article/518eeac978cf4cdfb3505928c36ddd3d
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157055 (2016)
Generalized CD8+ T-cell impairment in chronic hepatitis C virus (HCV) infection and the contribution of liver-infiltrating CD8+ T-cells to the immunopathogenesis of this infection remain poorly understood. It is hypothesized that this impairment is p
Externí odkaz:
https://doaj.org/article/049c3c1aab8d4b6a8949aca103d9cf7a
Autor:
Manoj M. Lalu, Dawn Richards, Madison Foster, Brittany French, Angela M. Crawley, Kirsten M. Fiest, Kathryn Hendrick, Kimberly F. Macala, Asher A. Mendelson, Pat Messner, Stuart G. Nicholls, Justin Presseau, Cheryle A. Séguin, Patrick Sullivan, Bernard Thébaud, Dean A. Fergusson
Publikováno v:
Research Involvement and Engagement, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Background Patient engagement in research is the meaningful and collaborative interaction between patients and researchers throughout the research process. Patient engagement can help to ensure patient-oriented values and perspectives are in
Externí odkaz:
https://doaj.org/article/d1346b77fe94404e9245270fe80b7977
Autor:
Jiafeng Li, Agatha Vranjkovic, Daniel Read, Sean P. Delaney, William L. Stanford, Curtis L. Cooper, Angela M. Crawley
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe impact of chronic hepatic infection on antigen non-specific immune cells in circulation remains poorly understood. We reported lasting global hyperfunction of peripheral CD8 T cells in HCV-infected individuals with cirrhosis. Whether ge
Externí odkaz:
https://doaj.org/article/1e5fb1ff98184fb6a106294f2c5f8edf
Autor:
Erin Collins, Yannick Galipeau, Corey Arnold, Anne Bhéreur, Ronald Booth, Arianne C. Buchan, Curtis Cooper, Angela M. Crawley, Pauline S. McCluskie, Michaeline McGuinty, Martin Pelchat, Lynda Rocheleau, Raphael Saginur, Chris Gravel, Steven Hawken, Marc-André Langlois, Julian Little
Publikováno v:
Frontiers in Public Health, Vol 12 (2024)
IntroductionMore than 3 years into the pandemic, there is persisting uncertainty as to the etiology, biomarkers, and risk factors of Post COVID-19 Condition (PCC). Serological research data remain a largely untapped resource. Few studies have investi
Externí odkaz:
https://doaj.org/article/03769940dcf7465a9cf8e66c1dcde6b6
Autor:
Sylvie Faucher, Angela M Crawley, Wendy Decker, Alice Sherring, Dragica Bogdanovic, Tao Ding, Michele Bergeron, Jonathan B Angel, Paul Sandstrom
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6690 (2009)
BACKGROUND: IL-7 is an essential cytokine in T-cell development and homeostasis. It binds to the IL-7R receptor, a complex of the IL-7Ralpha (CD127) and common gamma (CD132) chains. There is significant interest in evaluating the expression of CD127
Externí odkaz:
https://doaj.org/article/11d27312ce42448ebde9721e0afc3f68
Autor:
Natasha A. Trzaskalski, Branka Vulesevic, My-Anh Nguyen, Natasha Jeraj, Evgenia Fadzeyeva, Nadya M. Morrow, Cassandra A.A. Locatelli, Nicole Travis, Antonio A. Hanson, Julia R.C. Nunes, Conor O’Dwyer, Jelske N. van der Veen, Ilka Lorenzen-Schmidt, Rick Seymour, Serena M. Pulente, Andrew C. Clément, Angela M. Crawley, René L. Jacobs, Mary-Anne Doyle, Curtis L. Cooper, Kyoung-Han Kim, Morgan D. Fullerton, Erin E. Mulvihill
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Elevated circulating dipeptidyl peptidase-4 (DPP4) is a biomarker for liver disease, but its involvement in gluconeogenesis and metabolic associated fatty liver disease progression remains unclear. Here, we identified that DPP4 in hepatocytes but not
Externí odkaz:
https://doaj.org/article/40cdcc7f6d5742ecbe16d60323de171c
Autor:
Yulia Alexandrova, Alexis Yero, Ralph-Sydney Mboumba Bouassa, Eve Comeau, Suzanne Samarani, Zabrina L. Brumme, Mark Hull, Angela M. Crawley, Marc-André Langlois, Jonathan B. Angel, Curtis L. Cooper, Judy Needham, Terry Lee, Joel Singer, Aslam H. Anis, Cecilia T. Costiniuk, Mohammad-Ali Jenabian
Publikováno v:
Viruses, Vol 15, Iss 2, p 575 (2023)
People living with HIV (PLWH) may be at risk for poor immunogenicity to certain vaccines, including the ability to develop immunological memory. Here, we assessed T-cell immunogenicity following three SARS-CoV-2 vaccine doses in PLWH versus uninfecte
Externí odkaz:
https://doaj.org/article/fb04cfcda06b48c0a9d4349e9ec31f7c