Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Angela M Arensdorf"'
Autor:
Suresh Marada, Gemma Navarro, Ashley Truong, Daniel P Stewart, Angela M Arensdorf, Sigrid Nachtergaele, Edgar Angelats, Joseph T Opferman, Rajat Rohatgi, Peter J McCormick, Stacey K Ogden
Publikováno v:
PLoS Genetics, Vol 11, Iss 8, p e1005473 (2015)
The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the evolutionarily conserved Hedgehog (Hh) pathway. Although aspects of Smo signaling are conserved from Drosophila to vertebrates, significant differences h
Externí odkaz:
https://doaj.org/article/4c423f7fb3a84caa9fc72b796bf9aaa3
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
The unfolded protein response (UPR) responds to disruption of endoplasmic reticulum (ER) function by initiating signaling cascades that ultimately culminate in extensive transcriptional regulation. Classically, this regulation includes genes encoding
Externí odkaz:
https://doaj.org/article/879aa4ac819e4f74888ecc6514d44c27
Autor:
Diane DeZwaan-McCabe, Jesse D Riordan, Angela M Arensdorf, Michael S Icardi, Adam J Dupuy, D Thomas Rutkowski
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1003937 (2013)
Viral hepatitis, obesity, and alcoholism all represent major risk factors for hepatocellular carcinoma (HCC). Although these conditions also lead to integrated stress response (ISR) or unfolded protein response (UPR) activation, the extent to which t
Externí odkaz:
https://doaj.org/article/607b8f25d76e47069dd9b7ccf42ab584
Autor:
Janine M. Simmons, Dana Schloesser, Lisbeth Nielsen, James W. Gnadt, Todd S. Horowitz, Coryse St Hillaire-Clarke, Helene M. Langevin, Wen G. Chen, Yolanda F. Vallejo, Rita J. Valentino, Changhai Cui, Angela M. Arensdorf, Victoria M. Spruance
Publikováno v:
Trends Neurosci
Interoception refers to the representation of the internal states of an organism, and includes the processes by which it senses, interprets, integrates, and regulates signals from within itself. This review presents a unified research framework and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521be4dd0b8b33f79a8aded2fc2f82e0
https://pubmed.ncbi.nlm.nih.gov/33378655
https://pubmed.ncbi.nlm.nih.gov/33378655
Autor:
Matthew W. Frank, Angela M. Arensdorf, Jacob M. Menke, Miriam E. Dillard, Stacey K. Ogden, Charles O. Rock
Publikováno v:
Cell Reports, Vol 19, Iss 10, Pp 2074-2087 (2017)
Summary The G protein-coupled receptor Smoothened (Smo) is the signal transducer of the Sonic Hedgehog (Shh) pathway. Smo signals through G protein-dependent and -independent routes, with G protein-independent canonical signaling to Gli effectors req
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b026bfe4d985295ba416d74ab7397c89
https://europepmc.org/articles/PMC5520665/
https://europepmc.org/articles/PMC5520665/
The G protein-coupled receptor (GPCR) Smoothened (Smo) is the signal transducer of the developmentally and therapeutically relevant Hedgehog (Hh) pathway. Although recent structural analyses have advanced our understanding of Smo biology, several que
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3606536c35a9aab4c861fc2570e1319
https://europepmc.org/articles/PMC4593303/
https://europepmc.org/articles/PMC4593303/
Autor:
D. Thomas Rutkowski, Diane DeZwaan-McCabe, Adam J. Dupuy, Angela M. Arensdorf, Michael S. Icardi, Jesse D. Riordan
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 9, Iss 12, p e1003937 (2013)
PLoS Genetics, Vol 9, Iss 12, p e1003937 (2013)
Viral hepatitis, obesity, and alcoholism all represent major risk factors for hepatocellular carcinoma (HCC). Although these conditions also lead to integrated stress response (ISR) or unfolded protein response (UPR) activation, the extent to which t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298e49344c22ade5293bea857275d067
http://europepmc.org/articles/PMC3868529
http://europepmc.org/articles/PMC3868529
Publikováno v:
Journal of cell science. 126(Pt 17)
Activation of the unfolded protein response (UPR) by endoplasmic reticulum (ER) stress culminates in extensive gene regulation, with transcriptional upregulation of genes that improve the protein folding capacity of the organelle. However, a substant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8f71e851a74f3c3354c3f93fa120a5
https://pubmed.ncbi.nlm.nih.gov/23813955
https://pubmed.ncbi.nlm.nih.gov/23813955
Publikováno v:
Frontiers in Genetics
Frontiers in Genetics, Vol 4 (2013)
Frontiers in Genetics, Vol 4 (2013)
The mammalian unfolded protein response (UPR) is propagated by three ER-resident transmembrane proteins, each of which initiates a signaling cascade that ultimately culminates in production of a transcriptional activator. The UPR was originally chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326bdcbde059db2bf7e67070b339fe29
https://doi.org/10.3389/fgene.2013.00256
https://doi.org/10.3389/fgene.2013.00256
Autor:
Molly J. Pollpeter, Patrick L. Sinn, D. Thomas Rutkowski, Angela M. Arensdorf, Paul B. McCray, Janice M. Staber
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Hemophilia A, caused by a deficiency in factor VIII (FVIII), is the most severe inherited bleeding disorder. Hemophilia A is an attractive gene therapy candidate because even small increases in FVIII levels will positively alter the phenotype. While
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645c5a4487616cc41a3d779b88e6aeac
https://doi.org/10.1038/mtm.2014.42
https://doi.org/10.1038/mtm.2014.42