Výsledky vyhledávání - "Angela L. Mote"

THE SYSTEMIC EXPOSURE OF ANN-METHYL-d-ASPARTATE RECEPTOR ANTAGONIST IS LIMITED IN MICE BY THE P-GLYCOPROTEIN AND BREAST CANCER RESISTANCE PROTEIN EFFLUX TRANSPORTERS

Autor: Robert J. Barnaby, Cosette J. Serabjit-Singh, Luigina Bertolotti, Joseph W. Polli, Todd M. Baughman, Joan E. Humphreys, Angela L. Mote, Giovanni Vitulli, Kevin D. Read, Lindsey O. Webster, Kelly H. Jordan

Publikováno v: Drug Metabolism and Disposition. 32:722-726

This article is available online at http://dmd.aspetjournals.org ABSTRACT: GV196771 (E-4,6-dichloro-3-(2-oxo-1-phenyl-pyrrolidin-3-glyden- emethyl)-1H-indole-2 carboxylic acid) is a potent antagonist of the modulatory glycine site of the N-methyl-D-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c45942d2fe954230dcbcd882f0391e
https://doi.org/10.1124/dmd.32.7.722

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P‐glycoprotein Influences the Brain Concentrations of Cetirizine (Zyrtec®), a Second‐Generation Non‐Sedating Antihistamine

Autor: Jo A. Salisbury, Joan E. Humphreys, Cosette J. Serabjit-Singh, Todd M. Baughman, Timothy K. Tippin, Kelly H. Jordan, Joseph W. Polli, Angela L. Mote

Publikováno v: Journal of Pharmaceutical Sciences. 92:2082-2089

Recent in vitro studies have suggested that P-glycoprotein (Pgp) and passive membrane permeability may influence the brain concentrations of non-sedating (second-generation) antihistamines. The purpose of this study was to determine the importance of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5448bc4ec1f72563033849add475017
https://doi.org/10.1002/jps.10453

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