Výsledky vyhledávání - "Angela L. Gaviglio"

Heparin‐binding epidermal growth factor‐like growth factor promotes neuroblastoma differentiation

Autor: Angela L. Gaviglio, Erik H. Knelson, Gerard C. Blobe

Publikováno v: The FASEB Journal. 31:1903-1915

High-risk neuroblastoma is characterized by undifferentiated neuroblasts and low schwannian stroma content. The tumor stroma contributes to the suppression of tumor growth by releasing soluble factors that promote neuroblast differentiation. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e8970755dffebe195e7708423fef8a
https://doi.org/10.1096/fj.201600828r

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Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth

Autor: Erik H. Knelson, Stephen G. Marcus, Gerard C. Blobe, Andrew B. Nixon, Angela L. Gaviglio, Jasmine C. Nee, Mark D. Starr

Publikováno v: Journal of Clinical Investigation. 124:3016-3031

Neuroblastoma prognosis is dependent on both the differentiation state and stromal content of the tumor. Neuroblastoma tumor stroma is thought to suppress neuroblast growth via release of soluble differentiating factors. Here, we identified critical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3de7102b0427bf67b5b0f70eef8c666
https://doi.org/10.1172/jci74270

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Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes

Autor: Carol A. Lange, Andrea R. Daniel, Douglas Yee, Julie H. Ostrander, Antonino B. D'Assoro, Angela L. Gaviglio, Yan Peng, Ganesh V. Raj, Todd P. Knutson, Preethi Ravindranathan

Publikováno v: Oncogene

Progesterone and estrogen are important drivers of breast cancer proliferation. Herein, we probed estrogen receptor-α (ER) and progesterone receptor (PR) cross-talk in breast cancer models. Stable expression of PR-B in PR-low/ER+ MCF7 cells increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12caa07ca9fa2b9559d3e794be00e64
http://europepmc.org/articles/PMC4112172

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Type III TGF-Î² receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma

Autor: Erik H. Knelson, Angela L. Gaviglio, Michael B. Armstrong, Alok K. Tewari, Karthikeyan Mythreye, Gerard C. Blobe

Publikováno v: Journal of Clinical Investigation. 123:4786-4798

Growth factors and their receptors coordinate neuronal differentiation during development, yet their roles in the pediatric tumor neuroblastoma remain unclear. Comparison of mRNA from benign neuroblastic tumors and neuroblastomas revealed that expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed11490f1de19458e55bce1da904703
https://doi.org/10.1172/jci69657

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The Progesterone Receptor Hinge Region Regulates the Kinetics of Transcriptional Responses Through Acetylation, Phosphorylation, and Nuclear Retention

Autor: Lauren Czaplicki, Carol A. Lange, Andrea R. Daniel, Angela L. Gaviglio, Christopher J. Hillard, Daniel Housa

Publikováno v: Molecular Endocrinology. 24:2126-2138

Progesterone receptors (PRs) are critical regulators of mammary gland development and contributors to breast cancer progression. Posttranslational modifications of PR have been shown to alter hormone responsiveness. Site-directed mutagenesis demonstr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac168aa725ddb898b1b77d4d90e5714c
https://doi.org/10.1210/me.2010-0170

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Abstract 2674: Stroma biology identifies heparins as differentiating agents in neuroblastoma

Autor: Erik H. Knelson, Stephen G. Marcus, Angela L. Gaviglio, Andrew B. Nixon, Gerard C. Blobe, Mark D. Starr, Jasmine C. Nee

Publikováno v: Cancer Research. 74:2674-2674

The neuroblastoma tumor stroma is thought to suppress neuroblast growth via release of soluble differentiating factors. Here we identify these factors and design a novel therapy based on their mechanism of action. We show that expression of heparan-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66c0a7cf93977fd577f942c506883fe7
https://doi.org/10.1158/1538-7445.am2014-2674

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Abstract 3572: Unliganded progesterone receptors augment estrogen-induced growth of breast cancer cells via co-regulation of estrogen receptor target genes

Autor: Todd P. Knutson, Andrea R. Daniel, Douglas Yee, Julie H. Ostrander, Angela L. Gaviglio, Carol A. Lange

Publikováno v: Cancer Research. 73:3572-3572

The ovarian steroid hormone receptors, Progesterone and Estrogen Receptors (PR, ER), are important drivers of breast cancer proliferation. Recently, ER and IGF1R were shown to function within the same signaling pathways. Notably, PR cross-talk with t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebf6667b1a33ad52c1b793ccba1fd550
https://doi.org/10.1158/1538-7445.am2013-3572

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Abstract 5041: The type III TGF-beta receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma

Autor: Mark D. Starr, Karthikeyan Mythreye, Andrew B. Nixon, Alok K. Tewari, Gerard C. Blobe, Angela L. Gaviglio, Erik H. Knelson, Michael B. Armstrong

Publikováno v: Cancer Research. 73:5041-5041

Growth factors and their receptors coordinate neuronal differentiation during development, yet their roles in the pediatric tumor neuroblastoma remain unclear. Here we report that expression of type III TGF-beta receptor (TβRIII) mRNA and protein de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adbf847c033ebea0047cf06a7a34f94a
https://doi.org/10.1158/1538-7445.am2013-5041

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