Zobrazeno 1 - 10
of 255
pro vyhledávání: '"Angela L Jefferson"'
Autor:
Alex G Nackenoff, Timothy J Hohman, Sarah M Neuner, Carolyn S Akers, Nicole C Weitzel, Alena Shostak, Shawn M Ferguson, Bret Mobley, David A Bennett, Julie A Schneider, Angela L Jefferson, Catherine C Kaczorowski, Matthew S Schrag
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009406 (2021)
Phospholipase D3 (PLD3) is a protein of unclear function that structurally resembles other members of the phospholipase D superfamily. A coding variant in this gene confers increased risk for the development of Alzheimer's disease (AD), although the
Externí odkaz:
https://doaj.org/article/5332a5a2c04747fa938b639208224775
Autor:
Timothy J Hohman, Logan Dumitrescu, Amy Oksol, Madison Wagener, Katherine A Gifford, Angela L Jefferson, Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188501 (2017)
Biomarker definitions for preclinical Alzheimer's disease (AD) have identified individuals with neurodegeneration (ND+) without β-amyloidosis (Aβ-) and labeled them with suspected non-AD pathophysiology (SNAP). We evaluated Apolipoprotein E (APOE)
Externí odkaz:
https://doaj.org/article/13c9703896ed43f2a9525c3cb80ad240
Autor:
Rebecca L. Winfree, Emma Nolan, Logan Dumitrescu, Kaj Blennow, Henrik Zetterberg, Katherine A. Gifford, Kimberly R. Pechman, Mabel Seto, Vladislav A. Petyuk, Yanling Wang, Julie Schneider, David A. Bennett, Angela L. Jefferson, Timothy J. Hohman, the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract Recent evidence suggests that Alzheimer’s disease (AD) genetic risk variants (rs1582763 and rs6591561) of the MS4A locus are genome-wide significant regulators of soluble TREM2 levels such that the minor allele of the protective variant (r
Externí odkaz:
https://doaj.org/article/7f931778e48b4a1db9dee9d86d867c84
Autor:
Katherine A Gifford, Dandan Liu, Timothy J Hohman, Meng Xu, Xue Han, Raymond R Romano, Laura R Fritzsche, Ty Abel, Angela L Jefferson
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141831 (2015)
BackgroundThis study examines whether different sources of cognitive complaint (i.e., self and informant) predict Alzheimer's disease (AD) neuropathology in elders with mild cognitive impairment (MCI).MethodsData were drawn from the National Alzheime
Externí odkaz:
https://doaj.org/article/411d7cb7422943d1ab5a1bc0cdc5b8cc
Autor:
Derek B. Archer, Kurt Schilling, Niranjana Shashikumar, Varuna Jasodanand, Elizabeth E. Moore, Kimberly R. Pechman, Murat Bilgel, Lori L. Beason‐Held, Yang An, Andrea Shafer, Luigi Ferrucci, Shannon L. Risacher, Katherine A. Gifford, Bennett A. Landman, Angela L. Jefferson, Andrew J. Saykin, Susan M. Resnick, Timothy J. Hohman, for the Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 4, Pp n/a-n/a (2023)
Abstract Introduction It is unclear how rates of white matter microstructural decline differ between normal aging and abnormal aging. Methods Diffusion MRI data from several well‐established longitudinal cohorts of aging (Alzheimer's Disease Neuroi
Externí odkaz:
https://doaj.org/article/20540831140341e68e8fcfd1aa55351e
Autor:
Katie E. Osborn, Omair A. Khan, Hailey A. Kresge, Corey W. Bown, Dandan Liu, Elizabeth E. Moore, Katherine A. Gifford, Lealani Mae Y. Acosta, Susan P. Bell, Timothy J. Hohman, Kaj Blennow, Henrik Zetterberg, Angela L. Jefferson
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 700-709 (2019)
Abstract Introduction Neuroaxonal damage may contribute to cognitive changes preceding clinical dementia. Accessible biomarkers are critical for detecting such damage. Methods Plasma and cerebrospinal fluid (CSF) neurofilament light (NFL) were relate
Externí odkaz:
https://doaj.org/article/f5a717ea79574a539830b9626e99931b
Autor:
Mabel Seto, Logan Dumitrescu, Emily R. Mahoney, Annah M. Sclafani, Philip L. De Jager, Vilas Menon, Mary E.I. Koran, Renã A. Robinson, Douglas M. Ruderfer, Nancy J. Cox, Nicholas T. Seyfried, Angela L. Jefferson, Julie A. Schneider, David A. Bennett, Vladislav A. Petyuk, Timothy J. Hohman
Publikováno v:
Neurobiol Aging
The Vascular Endothelial Growth Factor (VEGF) signaling family has been implicated in neuroprotection and clinical progression in Alzheimer’s disease (AD). Previous work in postmortem human dorsolateral prefrontal cortex demonstrated that higher tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b99cf7020232587c4fd9718cdee149
https://doi.org/10.1016/j.neurobiolaging.2023.01.010
https://doi.org/10.1016/j.neurobiolaging.2023.01.010
Autor:
Julia B. Libby, Mabel Seto, Omair A. Khan, Dandan Liu, Vlad Petyuk, Nekesa C. Oliver, Min Ji Choi, Marsalas Whitaker, Khiry L. Patterson, Albert B. Arul, Katherine A. Gifford, Kaj Blennow, Henrik Zetterberg, Logan Dumitrescu, Renã AS Robinson, Angela L. Jefferson, Timothy J. Hohman
Publikováno v:
Neurobiol Aging
The vascular endothelial growth factor (VEGF) family of genes has been implicated in the clinical development of Alzheimer’s Disease (AD). A previous study identified associations between gene expression of VEGF family members in the prefrontal cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b5a6ba45e9edd16a07d590830bc5b0
https://doi.org/10.1016/j.neurobiolaging.2023.01.002
https://doi.org/10.1016/j.neurobiolaging.2023.01.002
Autor:
Corey W. Bown, Omair A. Khan, Dandan Liu, Samuel W. Remedios, Kimberly R. Pechman, James G Terry, Sangeeta Nair, L. Taylor Davis, Bennett A. Landman, Katherine A. Gifford, Timothy J. Hohman, John Jeffrey Carr, Angela L. Jefferson
Publikováno v:
Neurobiology of Aging. 124:85-97
Enlarged perivascular spaces (ePVS) are difficult to quantify, and their etiologies and consequences are poorly understood. Vanderbilt Memory and Aging Project participants (n = 327, 73 ± 7 years) completed 3T brain MRI to quantify ePVS volume and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5785b11101aacc5a6fc132627f127f70
https://doi.org/10.1016/j.neurobiolaging.2022.10.014
https://doi.org/10.1016/j.neurobiolaging.2022.10.014
Autor:
Rebecca L. Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A. Bennett, Angela L. Jefferson, Timothy J. Hohman
Publikováno v:
Acta Neuropathologica. 145:733-747
Previous post-mortem assessments of TREM2 expression and its association with brain pathologies have been limited by sample size. This study sought to correlate region-specific TREM2 mRNA expression with diverse neuropathological measures at autopsy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ebe424365d605fa547ad2607ae52c40
https://doi.org/10.1007/s00401-023-02564-2
https://doi.org/10.1007/s00401-023-02564-2