Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Angela Kallenbach"'
1
Integrated Fourier Transform Infrared Imaging and Proteomics for Identification of a Candidate Histochemical Biomarker in Bladder Cancer
Autor: Frederik Großerueschkamp, Heiko U. Käfferlein, Hendrik Jütte, Thomas Brüning, Klaus Gerwert, Karin Schork, Joachim Noldus, Martin Eisenacher, Kathrin E. Witzke, Angela Kallenbach-Thieltges, Katrin Marcus, Thilo Bracht, Melanie Horn, Andrea Tannapfel, Nicolas von Landenberg, Florian Roghmann, Barbara Sitek
Publikováno v: The American journal of pathology. 189(3)
Histopathological differentiation between severe urocystitis with reactive urothelial atypia and carcinoma in situ (CIS) can be difficult, particularly after a treatment that deliberately induces an inflammatory reaction, such as intravesical instill
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0198f3cbc741caa7f47c7b8f11e76b
https://pubmed.ncbi.nlm.nih.gov/30770125
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2
Quantum Cascade Laser-Based Infrared Microscopy for Label-Free and Automated Cancer Classification in Tissue Sections
Autor: Frederik Großerueschkamp, Andrea Tannapfel, Claus Kuepper, Angela Kallenbach-Thieltges, Hendrik Juette, Klaus Gerwert
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
A feasibility study using a quantum cascade laser-based infrared microscope for the rapid and label-free classification of colorectal cancer tissues is presented. Infrared imaging is a reliable, robust, automated, and operator-independent tissue clas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c7bc7807a3988831cd65eb12f008ef
https://doi.org/10.1038/s41598-018-26098-w
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4
Label-free classification of colon cancer grading using infrared spectral histopathology
Autor: Andrea Tannapfel, Angela Kallenbach-Thieltges, Klaus Gerwert, Axel Mosig, Claus Kuepper, Frederik Großerueschkamp
Publikováno v: Faraday discussions. 187
In recent years spectral histopathology (SHP) has been established as a label-free method to identify cancer within tissue. Herein, this approach is extended. It is not only used to identify tumour tissue with a sensitivity of 94% and a specificity o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d29248c01fbf94fb59bbd4e26bff29
https://pubmed.ncbi.nlm.nih.gov/27064063
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5
Systematic approach to group-specific isotopic labeling of proteins for vibrational spectroscopy
Autor: Angela Kallenbach, Sven Brucker, Klaus Gerwert, Carsten Kötting, Helmut E. Meyer, Bettina Warscheid
Publikováno v: Vibrational Spectroscopy. 48:28-36
Group-specific isotopic labeling of proteins using stable isotopes such as 15 N, 13 C, or 2 H is a widely applied method for the accurate assignment of signals in FTIR spectroscopy. In this work, we report a systematic study on the metabolic incorpor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78d8b15c4821d0238b8e74a1704bdd35
https://doi.org/10.1016/j.vibspec.2007.11.003
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6
The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy
Autor: Carsten Kötting, Klaus Gerwert, Yan Suveyzdis, Alfred Wittinghofer, Angela Kallenbach
Publikováno v: Proceedings of the National Academy of Sciences. 105:6260-6265
Members of the Ras superfamily of small G proteins play key roles in signal transduction pathways, which they control by GTP hydrolysis. They are regulated by GTPase activating proteins (GAPs). Mutations that prevent hydrolysis cause severe diseases
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f86d537554eee227f5475eeeffa8e9
https://doi.org/10.1073/pnas.0712095105
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7
Marker-free automated histopathological annotation of lung tumour subtypes by FTIR imaging
Autor: Dirk Theegarten, Matthias Altmayer, Frederik Großerueschkamp, Thomas Behrens, Klaus Gerwert, Angela Kallenbach-Thieltges, Thomas Brüning, Georgios Stamatis
Publikováno v: The Analyst. 140(7)
By integration of FTIR imaging and a novel trained random forest classifier, lung tumour classes and subtypes of adenocarcinoma are identified in fresh-frozen tissue slides automated and marker-free. The tissue slices are collected under standard ope
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab657ba77db9a4e97fdac8bbe59c989f
https://pubmed.ncbi.nlm.nih.gov/25529256
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8
Immunohistochemistry, histopathology and infrared spectral histopathology of colon cancer tissue sections
Autor: Klaus Gerwert, Andrea Tannapfel, Angela Kallenbach-Thieltges, Axel Mosig, Frederik Großerüschkamp, Max Diem
Publikováno v: Journal of biophotonics. 6(1)
During the past years, many studies have shown that infrared spectral histopathology (SHP) can distinguish different tissue types and disease types independently of morphological criteria. In this manuscript, we report a comparison of immunohistochem
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7131aa8fb3f5387a95dabb62bd0278af
https://pubmed.ncbi.nlm.nih.gov/23225612
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10
Surface change of Ras enabling effector binding monitored in real time at atomic resolution
Autor: Carsten Kötting, Yan Suveyzdis, Klaus Gerwert, Carolin Eichholz, Angela Kallenbach
Publikováno v: Chembiochem : a European journal of chemical biology. 8(7)
Ras, the prototype of the Ras superfamily, acts as a molecular switch for cell growth. External growth signals induce a GDP-to-GTP exchange. This modifies the Ras surface (Ras(on)GTP) and enables effector binding, which then activates signal-transduc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb97266b06cb6b3cea4f4837ffa82b5a
https://pubmed.ncbi.nlm.nih.gov/17385754
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