Výsledky vyhledávání - "Angela K. W. Lai"

Aldose reductase deficiency leads to oxidative stress-induced dopaminergic neuronal loss and autophagic abnormality in an animal model of Parkinson's disease

Autor: Sookja K. Chung, Angela K. W. Lai, Onyou Hwang, Patrick Ka Kit Yeung, Hyo Jin Son, Xu Zhang, Stephen S.M. Chung

Publikováno v: Neurobiology of Aging. 50:119-133

Fungicide exposure causes degeneration of dopaminergic neurons and contributes to Parkinson's disease (PD). Benomyl inhibits enzymes responsible for detoxifying the reactive dopamine metabolite 3,4-dihydroxyphenylacetaldehyde. Aldose reductase (AR) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f50e7a566b853b521f823b6579e6a5
https://doi.org/10.1016/j.neurobiolaging.2016.11.008

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Exchange protein activated by cAMP 1(Epac1)‐deficient mice develop β‐cell dysfunction and metabolic syndrome

Autor: Xinmei Zhang, Stephen S.M. Chung, Andrew C. P. Tai, Sookja K. Chung, Aimin Xu, Alan K. L. Kai, Angela K. W. Lai, Patrick Ka Kit Yeung, Karen S. Lam, Jian Wang, Sidney Tam, Amy K. M. Lam, Paul M. Vanhoutte, Ying Xian Chen, Johannes L. Bos

Publikováno v: The FASEB Journal. 27:4122-4135

Previously, exchange protein directly activated by cAMP 2 (Epac2) and PKA were known to play a role in glucose-stimulated insulin secretion (GSIS) by pancreatic β cells. The present study shows that Epac1 mRNA is also expressed by β cells. Therefor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a1bfc4e54f13c7a3dd2ee928f341df
https://doi.org/10.1096/fj.13-230433

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H5N1 Influenza Virus–Induced Mediators Upregulate RIG-I in Uninfected Cells by Paracrine Effects Contributing to Amplified Cytokine Cascades

Autor: Yu-Lung Lau, CY Cheung, Renee W. Y. Chan, Huawei Mao, Suki M. Y. Lee, Kenrie P Y Hui, Angela K. W. Lai, Wenwei Tu, Joseph S. M. Peiris, Yi Guan, Michael C. W. Chan

Publikováno v: The Journal of Infectious Diseases. 204:1866-1878

Highly pathogenic avian influenza H5N1 viruses cause severe disease in humans, and dysregulation of cytokine responses is believed to contribute to the pathogenesis of human H5N1 disease. However, mechanisms leading to the increased induction of proi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7927799a35d244eeed77637ca0d6049f
https://doi.org/10.1093/infdis/jir665

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Selective astrocytic endothelin-1 overexpression contributes to dementia associated with ischemic stroke by exaggerating astrocyte-derived amyloid secretion

Autor: Amy C. Y. Lo, Angela K. W. Lai, Ed X. Wu, Chi W Cheung, Stephen S.M. Chung, Patrick Ka Kit Yeung, Sookja K. Chung, Maggie C. Y. Ho, Victor K L Hung, Kevin C. Chan

Endothelin-1 (ET-1) is synthesized by endothelial cells and astrocytes in stroke and in brains of Alzheimer’s disease patients. Our transgenic mice with ET-1 overexpression in the endothelial cells (TET-1) showed more severe blood–brain barrier (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc81cd3d3274d9316b42c1fd0a88e99
http://hdl.handle.net/10722/218637

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