Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Angela K. Odle"'
Autor:
Jewel Banik, Ana Rita Silva Moreira, Juchan Lim, Sophia Tomlinson, Linda L. Hardy, Alex Lagasse, Anessa Haney, Meghan R. Crimmins, Ulrich Boehm, Angela K. Odle, Melanie C. MacNicol, Gwen V. Childs, Angus M. MacNicol
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The pituitary functions as a master endocrine gland that secretes hormones critical for regulation of a wide variety of physiological processes including reproduction, growth, metabolism and stress responses. The distinct hormone-producing c
Externí odkaz:
https://doaj.org/article/367dcc30f1c442de93a8c3febc716b13
Autor:
Tiffany K. Miles, Melody L. Allensworth, Ana Rita Silva Moreira, Angela K. Odle, Anessa Haney, Alexandra Lagasse, Angus M. MacNicol, Gwen V. Childs
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 79-79 (2022)
OBJECTIVES/GOALS: Maternal undernutrition, a form of malnutrition, can alter neonatal leptin signaling and result in metabolic dysfunction in adulthood. We developed a mild undernutrition model to relate more to societys nutritional challenges and to
Externí odkaz:
https://doaj.org/article/d52dc189fc304e85b63bd8c695ca0821
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3312 (2021)
The proper expression of gonadotropin-releasing hormone receptors (GnRHRs) by pituitary gonadotropes is critical for maintaining maximum reproductive capacity. GnRH receptor expression must be tightly regulated in order to maintain the normal pattern
Externí odkaz:
https://doaj.org/article/e0d211d958b644f79fc339e83b9043e7
Autor:
Angela K. Odle, Noor Akhter, Mohsin M. Syed, Melody L. Allensworth-James, Helen Beneš, Andrea I. Melgar Castillo, Melanie C. MacNicol, Angus M. MacNicol, Gwen V. Childs
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2018)
The adipokine leptin signals the body’s nutritional status to the brain, and particularly, the hypothalamus. However, leptin receptors (LEPRs) can be found all throughout the body and brain, including the pituitary. It is known that leptin is permi
Externí odkaz:
https://doaj.org/article/aa3d92d26f8d4d89974fcf1b93f185fa
Autor:
Thomas Groves, Antiño R. Allen, Steven W. Barger, Yang Ou, Jakeira E. Davis, Angela K. Odle, Rachel D. Hendrix, Gwen V. Childs
Publikováno v:
Neurobiology of aging
Alzheimer’s disease (AD) is associated with disturbances in blood glucose regulation, and type-2 diabetes elevates the risk for dementia. A role for amyloid-β peptide (Aβ) in linking these age-related conditions has been proposed, tested primaril
Autor:
Melanie C. MacNicol, Melody Allensworth-James, Gwen V. Childs, Tiffany K. Miles, Anessa Haney, Angus M. MacNicol, Ana Rita Silva Moreira, Angela K. Odle
Publikováno v:
J Endocrinol
Anterior pituitary somatotropes are important metabolic sensors responding to leptin by secreting growth hormone (GH). However, reduced leptin signals caused by fasting have not always correlated with reduced serum GH. Reports show that fasting may s
Autor:
Elena Ambrogini, Michela Palmieri, Teenamol E Joseph, Horacio Gomez-Acevedo, Gwen V Childs, Angela K Odle, Tiffany Miles, Stavros C Manolagas
Publikováno v:
Journal of the Endocrine Society. 6:A420-A420
Oxidative stress-induced lipid peroxidation generates oxidized phospholipids (OxPL), such as oxidized phosphatidylcholine, that are pro-inflammatory moieties present on oxidized low density lipoproteins and apoptotic cells. OxPL have been implicated
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3312, p 3312 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The proper expression of gonadotropin-releasing hormone receptors (GnRHRs) by pituitary gonadotropes is critical for maintaining maximum reproductive capacity. GnRH receptor expression must be tightly regulated in order to maintain the normal pattern
Autor:
Anessa Haney, Angela K. Odle, Gwen V. Childs, Tiffany K Miles, Ana Rita Silva Moreira, Melody Allensworth, Alexandra Lagasse, Angus M. MacNicol
Publikováno v:
Journal of the Endocrine Society
Malnutrition alters leptin signaling, resulting in dysregulation of pituitary somatotropes that may be sex-specific. We reported sex differences in acute fasting responses with reductions in serum leptin in males, but not females (1). Maternal undern
Publikováno v:
Endocrinology
A healthy nutritional state is required for all aspects of reproduction and is signaled by the adipokine leptin. Leptin acts in a relatively narrow concentration range: too much or too little will compromise fertility. The leptin signal timing is imp