Výsledky vyhledávání - "Angela K. Namenuk"

High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR

Autor: Josephine P. Briggs, Kyu Hong, Leonard G. Presta, Betty Li, Angela K. Namenuk, Judith A. Fox, Dong Xie, Julie Rae, Y. Gloria Meng, Jadine Lai, Andrew Stadlen, Robert L. Shields

Publikováno v: Journal of Biological Chemistry. 276:6591-6604

Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human FcγRI, FcγRIIA, FcγRIIB, FcγRIIIA, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef7f21b94ef831ce45a573066d3f0fd3
https://doi.org/10.1074/jbc.m009483200

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Rapid assembly of 'subtiligase' substrates to elucidate optimal ligation junctures

Autor: J. Kevin Judice, John Burnier, Angela K. Namenuk

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:1961-1966

A method allowing for the rapid selection of optimal ligation junctures for the enzyme “subtiligase” is described. To expedite production of the glycolate ester substrate peptides for subtiligase, we have modified the protocols for compatibility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f6431e0584510637c796f5fae94ad9f
https://doi.org/10.1016/0960-894x(96)00351-4

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Engineering therapeutic antibodies for improved function

Autor: Robert L. Shields, Angela K. Namenuk, Y. G. Meng, Kyu Hong, L. G. Presta

Publikováno v: Biochemical Society transactions. 30(4)

The binding sites on human IgG1 for human Fc gamma receptor (Fc gamma R) I, Fc gamma RIIa, Fc gamma RIIb, Fc gamma RIIIa and neonatal FcR have been mapped. A common set of IgG1 residues is involved in binding to all Fc gamma Rs, while Fc gamma RII an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e61f9cc63c74e37bfac30bf398b741
https://pubmed.ncbi.nlm.nih.gov/12196120

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Analysis of mixture sequences derived from edman degradation data

Autor: Susan C. Wong, James Yashio, John T. Stults, Angela K. Namenuk, Colin K. Watanabe, William J. Henzel

Publisher Summary The adaptation of polyvinylidene difluoride (PVDF) for electroblotting proteins from gels has facilitated the use of Edman degradation for protein analysis. The two algorithms that are designed to sort mixture sequences are SEQSORT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::175c3ef3467f6a084ad933cf35eb5bcf
https://doi.org/10.1016/s1080-8914(96)80038-x

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