Zobrazeno 1 - 10 of 180 pro vyhledávání: '"Angela J. Russell"'
1
Akademický článek
A tubulin binding molecule drives differentiation of acute myeloid leukemia cells
Autor: Thomas R. Jackson, Aini Vuorinen, Laia Josa-Culleré, Katrina S. Madden, Daniel Conole, Thomas J. Cogswell, Isabel V.L. Wilkinson, Laura M. Kettyle, Douzi Zhang, Alison O’Mahony, Deanne Gracias, Lorna McCall, Robert Westwood, Georg C. Terstappen, Stephen G. Davies, Edward W. Tate, Graham M. Wynne, Paresh Vyas, Angela J. Russell, Thomas A. Milne
Publikováno v: iScience, Vol 25, Iss 8, Pp 104787- (2022)
Summary: Despite much progress in developing better drugs, many patients with acute myeloid leukemia (AML) still die within a year of diagnosis. This is partly because it is difficult to identify therapeutic targets that are effective across multiple
Externí odkaz: https://doaj.org/article/41383f2f5a8d4ffeb2940ad8bb573d15
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2
Akademický článek
Anthelmintic drug discovery: target identification, screening methods and the role of open science
Autor: Frederick A. Partridge, Ruth Forman, Carole J. R. Bataille, Graham M. Wynne, Marina Nick, Angela J. Russell, Kathryn J. Else, David B. Sattelle
Publikováno v: Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1203-1224 (2020)
Helminths, including cestodes, nematodes and trematodes, are a huge global health burden, infecting hundreds of millions of people. In many cases, existing drugs such as benzimidazoles, diethylcarbamazine, ivermectin and praziquantel are insufficient
Externí odkaz: https://doaj.org/article/00c5a4befa5e42acba226a9346c95457
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3
Akademický článek
Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment
Autor: Camilo E. Quevedo, Abimael Cruz-Migoni, Nicolas Bery, Ami Miller, Tomoyuki Tanaka, Donna Petch, Carole J. R. Bataille, Lydia Y. W. Lee, Phillip S. Fallon, Hanna Tulmin, Matthias T. Ehebauer, Narcis Fernandez-Fuentes, Angela J. Russell, Stephen B. Carr, Simon E. V. Phillips, Terence H. Rabbitts
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Intracellular antibodies can inhibit disease-relevant protein interactions, but inefficient cellular uptake limits their utility. Using a RAS-targeting intracellular antibody as a screening tool, the authors here identify small molecules that inhibit
Externí odkaz: https://doaj.org/article/67c80be1d0a14b3aa0feecf6b7e3b832
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4
Akademický článek
An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes
Autor: Frederick A. Partridge, Anwen E. Brown, Steven D. Buckingham, Nicky J. Willis, Graham M. Wynne, Ruth Forman, Kathryn J. Else, Alison A. Morrison, Jacqueline B. Matthews, Angela J. Russell, David A. Lomas, David B. Sattelle
Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 1, Pp 8-21 (2018)
Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of therapeutic compounds is limited and parasite resistance to the existing anthelmintic comp
Externí odkaz: https://doaj.org/article/c42f40dcf1474713bfa44bf04087ce17
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5
Akademický článek
Identification and Preliminary Structure-Activity Relationship Studies of 1,5-Dihydrobenzo[e][1,4]oxazepin-2(3H)-ones That Induce Differentiation of Acute Myeloid Leukemia Cells In Vitro
Autor: Laia Josa-Culleré, Thomas J. Cogswell, Irene Georgiou, Morgan Jay-Smith, Thomas R. Jackson, Carole J. R. Bataille, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
Publikováno v: Molecules, Vol 26, Iss 21, p 6648 (2021)
Acute myeloid leukemia (AML) is the most aggressive type of blood cancer, and there is a continued need for new treatments that are well tolerated and improve long-term survival rates in patients. Induction of differentiation has emerged as a promisi
Externí odkaz: https://doaj.org/article/371c3b38b9e44be49d8dc114324e28ce
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6
Pilot Study to Quantify Palladium Impurities in Lead-like Compounds Following Commonly Used Purification Techniques
Autor: Maria Chatzopoulou, Katrina S. Madden, Liam J. Bromhead, Christopher Greaves, Thomas J. Cogswell, Solange Da Silva Pinto, Sébastien R. G. Galan, Irene Georgiou, Matthew S. Kennedy, Alice Kennett, Geraint Apps, Angela J. Russell, Graham M. Wynne
Publikováno v: ACS Medicinal Chemistry Letters. 13:262-270
Palladium-catalyzed reactions are among the most commonly used procedures in organic synthesis. The products have a range of uses, including as intermediates in total synthesis and as screening compounds for drug discovery or agrochemical projects. D
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0314b69ec7fbe32e5300d6f3aae3078
https://doi.org/10.1021/acsmedchemlett.1c00638
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