Lonidamine Causes Inhibition of Angiogenesis-Related Endothelial Cell Functions

Autor: Donatella Del Bufalo, Daniela Trisciuoglio, Marco Scarsella, Giulia D'Amati, Antonio Candiloro, Angela Iervolino, Carlo Leonetti, Gabriella Zupi

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 6, Iss 5, Pp 513-522 (2004)

The aim of this study was to assess whether lonidamine (LND) interferes with some steps in angiogenesis progression. We report here, for the first time, that LND inhibited angiogenic-related endothelial cell functions in a dose-dependent manner (1-50

Externí odkaz: https://doaj.org/article/fa8f9e2ff973440088bc46cd77bec953

Kidins220/ARMS interacts with Pdzrn3, a protein containing multiple binding domains

Autor: Beatrice D'Orsi, Gaia Gestri, Marianna Vitiello, Massimiliano Andreazzoli, Manuela Barilari, Angela Iervolino, Luciana Dente, Elena Landi, Stephen W. Wilson

Publikováno v: Biochimie. 94(9):2054-2057

We report the identification of a novel partner of Kidins220/ARMS (Kinase D-interacting substrate of 220 kDa/Ankyrin Repeat-rich Membrane Spanning) an adaptor of neurotrophin receptors playing crucial roles during neurogenesis. Screening a phage disp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e461d5e3d346975c321913fe02f17f

Lonidamine Causes Inhibition of Angiogenesis-Related Endothelial Cell Functions

Autor: Daniela Trisciuoglio, Marco Scarsella, Angela Iervolino, Giulia d'Amati, Donatella Del Bufalo, Gabriella Zupi, Carlo Leonetti, Antonio Candiloro

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 6, Iss 5, Pp 513-522 (2004)

The aim of this study was to assess whether lonidamine (LND) interferes with some steps in angiogenesis progression. We report here, for the first time, that LND inhibited angiogenic-related endothelial cell functions in a dose-dependent manner (1-50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61220b5b965d33608a7f6d47ca34663d
https://doi.org/10.1593/neo.04133

BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2

Autor: Kenneth Campbell, Rossana Trotta, Danilo Perrotti, Vincenzo Cesi, Carlo Gambacorti-Passerini, Giorgia Santilli, Angela Iervolino, Bruno Calabretta, Clara Guerzoni, Fabrizio Condorelli, Michael A. Caligiuri

Publikováno v: Nature Genetics. 30:48-58

The arrest of differentiation is a feature of both chronic myelogenous leukemia cells in myeloid blast crisis and myeloid precursors that ectopically express the p210BCR-ABL oncoprotein; however, its underlying mechanisms remain poorly understood. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e43e6f23dc830935cdc04d985cdd5d9
https://doi.org/10.1038/ng791

Enhanced Glutathione Levels and Oxidoresistance Mediated by Increased Glucose-6-phosphate Dehydrogenase Expression

Autor: Salvatore Salzano, Matilde Valeria Ursini, Francesca Salvemini, Angela Iervolino, Stefania Filosa, Annamaria Franzè

Publikováno v: The Journal of biological chemistry
274 (1999): 2750–2757.
info:cnr-pdr/source/autori:Salvemini F, Franzé A, Iervolino A, Filosa S, Salzano S, Ursini MV./titolo:Enhanced glutathione levels and oxidoresistance mediated by increased glucose-6-phosphate dehydrogenase expression./doi:/rivista:The Journal of biological chemistry (Print)/anno:1999/pagina_da:2750/pagina_a:2757/intervallo_pagine:2750–2757/volume:274
274 (1999): 2750–2757. doi:10.1074/jbc.274.5.2750
info:cnr-pdr/source/autori:SALVEMINI F, FRANZE A, IERVOLINO A, FILOSA S, SALZANO S, URSINI MV/titolo:Enhanced glutathione levels oxidoresistance mediated by increased glucose-6-phosphate dehydrogenase expression/doi:10.1074%2Fjbc.274.5.2750/rivista:The Journal of biological chemistry (Print)/anno:1999/pagina_da:2750/pagina_a:2757/intervallo_pagine:2750–2757/volume:274

Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway that is responsible for the generation of NADPH, which is required in many detoxifying reactions. We have recently demonstrated that G6PD expression is induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb07789939ebf0e3beba3370521e5df6
https://doi.org/10.1074/jbc.274.5.2750