Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Angela I. Padilla"'
Autor:
Xavier Léry, L. Niño, D. Dardon, I. Merlin, Stéphane Dupas, Angela I. Padilla, Y. Gómez, Jean-Louis Zeddam, Magally Torres-Leguizamon, Jean-François Silvain, Claire Capdevielle-Dulac, A. Fossoud, A. Carnero, Olivier Dangles
Publikováno v:
Biological Invasions. 13:1505-1519
Tecia solanivora (Lepidoptera: Gelechiidae) is an invasive species that attacks the tubers of the potato Solanum tuberosum. It is considered a serious pest of potato crops and stocks in all countries where it occurs. In the present study, we sequence
Autor:
F.G. Njoroge, Weidong Pan, Angela I. Padilla, Anil K. Saksena, Stephane L. Bogen, Ashok Arasappan, Sumei Ruan, V. Girijavallabhan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4219-4223
Substitutions on the P(1) cyclobutyl side chain of SCH 503034 were studied by introduction of hydroxyl and fluoro substituents. Additionally, effects of fluoro substitution on other P1 moieties were evaluated.
Autor:
Angela I. Padilla, Yan Jin, Wanli Wu, Ashok Arasappan, Srikanth Venkatraman, Andrew Prongay, Viyyoor M. Girijavallabhan, F. George Njoroge, Jesse Wong, Tao Meng
Publikováno v:
Tetrahedron Letters. 48:6343-6347
A practical and efficient route toward synthesis of amino acid derivatives containing β-quaternary center has been developed using diastereoselective Strecker reaction. The method was employed for preparation of >100 g of β-methylcyclohexyl glycine
Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor
Autor:
Francisco Velazquez, Jianshe Kong, Regina Huelgas, Kuo-Chi Cheng, Hendrata Siska, Russell E. Pike, Ashok Arasappan, Neng-Yang Shih, Anil K. Saksena, Wanli Wu, Weidong Pan, Stephane L. Bogen, Tao Meng, Yuhua Huang, Latha G. Nair, Xiao Tong, Jesse Wong, F. George Njoroge, Viyyoor M. Girijavallabhan, Bruce A. Malcolm, Patrick Pinto, Srikanth Venkatraman, Bancha Vibulbhan, Paul McNamara, Robert Ralston, Sumei Ruan, Mousumi Sannigrahi, Piwinski John J, Kevin X. Chen, Yan Jin, Richard Morrison, Weiying Yang, Frank Bennett, Angela I. Padilla, Melissa Blackman, Vincent Madison, Andrew Prongay
Publikováno v:
ACS medicinal chemistry letters. 1(2)
Boceprevir (SCH 503034), 1, a novel HCV NS3 serine protease inhibitor discovered in our laboratories, is currently undergoing phase III clinical trials. Detailed investigations toward a second generation protease inhibitor culminated in the discovery
Autor:
Angela I. Padilla, Russell E. Pike, Frank Bennett, Stephane L. Bogen, Srikanth Venkatraman, Bancha Vibulbhan, Kevin X. Chen, Xiao Tong, F. George Njoroge, Anil K. Saksena, Viyyoor M. Girijavallabhan, Mousumi Sannigrahi, Edwin Jao, Joana Soares, Ashok Arasappan, Kuo-Chi Cheng
Publikováno v:
Journal of medicinal chemistry. 52(9)
Hepatitis C virus (HCV) infection is a global health crisis leading to liver cirrhosis, hepatocellular carcinoma, and liver failure in humans. Recently, we disclosed the discovery of Boceprevir, SCH 503034 (1), a novel, potent, selective, orally bioa
Autor:
Wanli Wu, Xiao Tong, Angela I. Padilla, Kevin X. Chen, Stephane L. Bogen, Viyyoor M. Girijavallabhan, Kuo-Chi Cheng, Mellissa Blackman, F. George Njoroge, Ashok Arasappan, John Pichardo, Latha G. Nair, Srikanth Venkatraman, Frank Bennett, Andrew Prongay
Publikováno v:
Bioorganicmedicinal chemistry. 17(13)
Hepatitis C Virus (HCV) infection is the major cause of chronic liver disease, leading to cirrhosis and hepatocellular carcinoma, which affects more than 200 million people worldwide. Currently the only therapeutic regimens are subcutaneous interfero
Autor:
Weidong Pan, Frank Bennett, Stephane L. Bogen, Xiao Tong, Latha G. Nair, Srikanth Venkatraman, Andrew Prongay, Bancha Vibulbhan, Neng-Yang Shih, Weiying Yang, Angela I. Padilla, Melissa Blackman, Kuo-Chi Cheng, Kevin X. Chen, F. George Njoroge, Ashok Arasappan
Publikováno v:
Journal of medicinal chemistry. 52(5)
The hepatitis C virus (HCV) infection is a leading cause of chronic liver disease. The moderate efficacy along with side effects of the current pegylated interferon and ribavirin combination therapy underscores the need for more effective and safer n
Autor:
Philip Magnus, Angela I. Padilla
Publikováno v:
Organic letters. 8(16)
[reaction: see text] A model study to support the intermediacy of the aziridinium ion in the proposed biogenetic origin of secu'amamine A from allosecurinine is described.
Autor:
Ashok Arasappan, Angela I. Padilla, Edwin Jao, Frank Bennett, Stephane L. Bogen, Kevin X. Chen, Russell E. Pike, Mousumi Sannigrahi, Joana Soares, Srikanth Venkatraman, Bancha Vibulbhan, Anil K. Saksena, Viyyoor Girijavallabhan, Xiao Tong, Kuo-Chi Cheng, F. George Njoroge
Publikováno v:
Journal of Medicinal Chemistry; May2009, Vol. 52 Issue 9, p2806-2817, 12p
Autor:
Kevin X. Chen, Latha Nair, Bancha Vibulbhan, Weiying Yang, Ashok Arasappan, Stephane L. Bogen, Srikanth Venkatraman, Frank Bennett, Weidong Pan, Melissa L. Blackman, Angela I. Padilla, Andrew Prongay, Kuo-Chi Cheng, Xiao Tong, Neng-Yang Shih, F. George Njoroge
Publikováno v:
Journal of Medicinal Chemistry; Mar2009, Vol. 52 Issue 5, p1370-1379, 10p