Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Angela Hoslin"'
Autor:
Paul K. Potter, Michael R. Bowl, Prashanthini Jeyarajan, Laura Wisby, Andrew Blease, Michelle E. Goldsworthy, Michelle M. Simon, Simon Greenaway, Vincent Michel, Alun Barnard, Carlos Aguilar, Thomas Agnew, Gareth Banks, Andrew Blake, Lauren Chessum, Joanne Dorning, Sara Falcone, Laurence Goosey, Shelley Harris, Andy Haynes, Ines Heise, Rosie Hillier, Tertius Hough, Angela Hoslin, Marie Hutchison, Ruairidh King, Saumya Kumar, Heena V. Lad, Gemma Law, Robert E. MacLaren, Susan Morse, Thomas Nicol, Andrew Parker, Karen Pickford, Siddharth Sethi, Becky Starbuck, Femke Stelma, Michael Cheeseman, Sally H. Cross, Russell G. Foster, Ian J. Jackson, Stuart N. Peirson, Rajesh V. Thakker, Tonia Vincent, Cheryl Scudamore, Sara Wells, Aziz El-Amraoui, Christine Petit, Abraham Acevedo-Arozena, Patrick M. Nolan, Roger Cox, Anne-Marie Mallon, Steve D. M. Brown
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Random mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute
Externí odkaz:
https://doaj.org/article/fa97ab87303c498f824c8286a0325379
Autor:
Dana Ranta, Jean Donadieu, Pekka Jaako, Alan J. Warren, Etienne Lengliné, Laetitia Kermasson, Christine Bellanné-Chantelot, Angela Hoslin, Alexandre Faille, Hubert Ducou Le Pointe, Patrick Revy, Abraham Acevedo-Arozena, Christine Bole-Feysot, Caroline Kannengiesser, Blandine Beaupain, Shengjiang Tan, Patrick Nitschke, Odile Fenneteau, Jean-Pierre de Villartay, Stefano Fumagalli, Maryline Poirée
Publikováno v:
Blood
Blood, American Society of Hematology, 2019, 134 (3), pp.277-290. ⟨10.1182/blood.2018893404⟩
Blood, American Society of Hematology, 2019, 134 (3), pp.277-290. ⟨10.1182/blood.2018893404⟩
Shwachman-Diamond syndrome (SDS) is a recessive disorder typified by bone marrow failure and predisposition to hematological malignancies. SDS is predominantly caused by deficiency of the allosteric regulator Shwachman-Bodian-Diamond syndrome that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb653f416e3aa410880bc9b4919cbdd
https://hal.archives-ouvertes.fr/hal-02347758
https://hal.archives-ouvertes.fr/hal-02347758
Autor:
Carlos A. Aguilar, Becky Starbuck, Siddharth Sethi, Paul Potter, Gemma Law, Marie Hutchison, Ruairidh King, Gareth Banks, Anne-Marie Mallon, Ines Heise, Thomas Agnew, Vincent Michel, Rosie Hillier, Femke Stelma, Patrick M. Nolan, Aziz El-Amraoui, Michelle Simon, Laura Wisby, Shelley Harris, Susan Morse, Laurence Goosey, Ian J. Jackson, Steve D. M. Brown, Lauren Chessum, Michelle Goldsworthy, Robert E MacLaren, Saumya Kumar, Michael Cheeseman, Andrew Parker, Sara Wells, Christine Petit, Sally H. Cross, Cheryl L. Scudamore, Stuart N. Peirson, Simon Greenaway, Heena V. Lad, Rajesh V. Thakker, Prashanthini Jeyarajan, Abraham Acevedo-Arozena, Andrew Blake, Karen Pickford, Sara Falcone, T Nicol, Angela Hoslin, Andy Haynes, Alun R. Barnard, Tonia L. Vincent, Russell G. Foster, Tertius Hough, Joanne Dorning, Michael R. Bowl, Roger D. Cox, A Blease
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications, 2016, 7, pp.12444. ⟨10.1038/ncomms12444⟩
Potter, P K, Bowl, M R, Jeyarajan, P, Wisby, L, Blease, A, Goldsworthy, M E, Simon, M M, Greenaway, S, Michel, V, Barnard, A, Aguilar, C, Agnew, T, Banks, G, Blake, A, Chessum, L, Dorning, J, Falcone, S, Goosey, L, Harris, S, Haynes, A, Heise, I, Hillier, R, Hough, T, Hoslin, A, Hutchison, M, King, R, Kumar, S, Lad, H V, Law, G, MacLaren, R E, Morse, S, Nicol, T, Parker, A, Pickford, K, Sethi, S, Starbuck, B, Stelma, F, Cheeseman, M, Cross, S H, Foster, R G, Jackson, I J, Peirson, S N, Thakker, R V, Vincent, T, Scudamore, C, Wells, S, El-Amraoui, A, Petit, C, Acevedo-Arozena, A, Nolan, P M, Cox, R, Mallon, A-M & Brown, S D M 2016, ' Novel gene function revealed by mouse mutagenesis screens for models of age-related disease ', Nature Communications, vol. 7, 12444 . https://doi.org/10.1038/ncomms12444
Nature Communications
Nature Communications, 2016, 7, pp.12444. ⟨10.1038/ncomms12444⟩
Potter, P K, Bowl, M R, Jeyarajan, P, Wisby, L, Blease, A, Goldsworthy, M E, Simon, M M, Greenaway, S, Michel, V, Barnard, A, Aguilar, C, Agnew, T, Banks, G, Blake, A, Chessum, L, Dorning, J, Falcone, S, Goosey, L, Harris, S, Haynes, A, Heise, I, Hillier, R, Hough, T, Hoslin, A, Hutchison, M, King, R, Kumar, S, Lad, H V, Law, G, MacLaren, R E, Morse, S, Nicol, T, Parker, A, Pickford, K, Sethi, S, Starbuck, B, Stelma, F, Cheeseman, M, Cross, S H, Foster, R G, Jackson, I J, Peirson, S N, Thakker, R V, Vincent, T, Scudamore, C, Wells, S, El-Amraoui, A, Petit, C, Acevedo-Arozena, A, Nolan, P M, Cox, R, Mallon, A-M & Brown, S D M 2016, ' Novel gene function revealed by mouse mutagenesis screens for models of age-related disease ', Nature Communications, vol. 7, 12444 . https://doi.org/10.1038/ncomms12444
Determining the genetic bases of age-related disease remains a major challenge requiring a spectrum of approaches from human and clinical genetics to the utilization of model organism studies. Here we report a large-scale genetic screen in mice emplo