Výsledky vyhledávání - "Angela Henkensiefken"

Akademický článek

613 HER2-XPAT, a novel protease-activatable prodrug T cell engager (TCE), with potent T-cell activation and efficacy in solid tumors and large predicted safety margins in non-human primate (NHP)

Autor: Fiore Cattaruzza, Ayesha Nazeer, Zachary Lange, Caitlin Koski, Mikhail Hammond, Trang Dao-Pick, Angela Henkensiefken, Mika Derynck, Volker Schellenberger, Bryan Irving

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Externí odkaz: https://doaj.org/article/251cfc5cf7644032b9a3fd31021d0f8c

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Precision-activated T-cell engagers targeting HER2 or EGFR and CD3 mitigate on-target, off-tumor toxicity for immunotherapy in solid tumors

Autor: Fiore Cattaruzza, Ayesha Nazeer, Milton To, Mikhail Hammond, Caitlin Koski, Lucas Y. Liu, V. Pete Yeung, Deena A. Rennerfeldt, Angela Henkensiefken, Michael Fox, Sharon Lam, Kari M. Morrissey, Zachary Lange, Vladimir N. Podust, Mika K. Derynck, Bryan A. Irving, Volker Schellenberger

Publikováno v: Nature Cancer. 4:485-501

To enhance the therapeutic index of T-cell engagers (TCEs), we engineered masked, precision-activated TCEs (XPAT proteins), targeting a tumor antigen (human epidermal growth factor receptor 2 (HER2) or epidermal growth factor receptor (EGFR)) and CD3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d08fc750f9f56209e1642cb13b83c12b
https://doi.org/10.1038/s43018-023-00536-9

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XPAT® proteins, conditionally activated T-cell engagers engineered to mitigate on-target, off-tumor toxicity for immunotherapy of solid tumors

Autor: Fiore Cattaruzza, Ayesha Nazeer, Milton To, Mikhail Hammond, Caitlin Koski, Lucas Liu, V. Pete Yeung, Deena Rennerfeldt, Angela Henkensiefken, Michael Fox, Sharon Lam, Kari Morrissey, Zachary Lange, Vladimir Podust, Mika Derynck, Bryan Irving, Volker Schellenberger

To enhance the therapeutic index of T-cell engagers (TCE), we engineered masked, conditionally active TCEs (XPAT proteins), targeting a tumor antigen (human epidermal growth factor receptor 2 [HER2] or epidermal growth factor receptor 2 [EGFR]) and C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9fbef64ebfb9ce12787efd733daeaf5
https://doi.org/10.21203/rs.3.rs-2045998/v1

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Abstract PS17-11: Her2-xpat, a novel protease-activatable prodrug t-cell engager (tce), exhibits potent t-cell activation and efficacy in her2 tumors, yielding large predicted safety margins based on non-human primate (nhp)

Autor: Mikhail Hammond, Ayesha Nazeer, Trang Dao-Pick, Mika K. Derynck, Caitlin Koski, Zachary Lange, Volker Schellenberger, Fiore Cattaruzza, Angela Henkensiefken, Bryan Irving

Publikováno v: Cancer Research. 81:PS17-11

Background TCEs are effective at inducing remissions in hematologic cancers but have been challenging in solid tumors due to on-target, off-tumor toxicity. Attempts to circumvent CRS include fractionated or step-up dosing and/or complex molecular des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46d7d683bff007e98c6fc5c0e2555bad
https://doi.org/10.1158/1538-7445.sabcs20-ps17-11

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Abstract 3376: HER2-XPAT and EGFR-XPAT: Pro-drug T-cell engagers (TCEs) engineered to address on-target, off-tumor toxicity with potent efficacy in vitro and in vivo and large safety margins in NHP

Autor: Ayesha Nazeer, Fiore Cattaruzza, Zachary Lange, Angela Henkensiefken, Bryan Irving, Mika K. Derynck, Mikhail Hammond, Volker Schellenberger, Caitlin Koski

Publikováno v: Cancer Research. 80:3376-3376

Background: TCEs have proven to be effective in creating durable remissions in hematologic malignancies but have been challenging in solid tumors due to on-target, off-tumor toxicity. To circumvent the toxicity, many have tried step-up, fractionated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d77c267077cbde98e9c5b85a3400c80
https://doi.org/10.1158/1538-7445.am2020-3376

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