Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Angela Helfricht"'
Autor:
Diana A. Llerena Schiffmacher, Shun-Hsiao Lee, Katarzyna W. Kliza, Arjan F. Theil, Masaki Akita, Angela Helfricht, Karel Bezstarosti, Camila Gonzalo-Hansen, Haico van Attikum, Matty Verlaan-de Vries, Alfred C. O. Vertegaal, Jan H. J. Hoeijmakers, Jurgen A. Marteijn, Hannes Lans, Jeroen A. A. Demmers, Michiel Vermeulen, Titia K. Sixma, Tomoo Ogi, Wim Vermeulen, Alex Pines
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to c
Externí odkaz:
https://doaj.org/article/ae22f3558ad948a0bf15ffe295f5314c
Autor:
Hyeongju Kim, Sophie Lenoir, Angela Helfricht, Taeyang Jung, Zhana K. Karneva, Yejin Lee, Wouter Beumer, Geert B. van der Horst, Herma Anthonijsz, Levi C.M. Buil, Frits van der Ham, Gerard J. Platenburg, Pasi Purhonen, Hans Hebert, Sandrine Humbert, Frédéric Saudou, Pontus Klein, Ji-Joon Song
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Huntington’s disease (HD) is a late-onset neurological disorder for which therapeutics are not available. Its key pathological mechanism involves the proteolysis of polyglutamine-expanded (polyQ-expanded) mutant huntingtin (mHTT), which generates N
Externí odkaz:
https://doaj.org/article/4386a98caf404dd9a84e53f674710b00
Autor:
Cristina Ribeiro-Silva, Mariangela Sabatella, Angela Helfricht, Jurgen A. Marteijn, Arjan F. Theil, Wim Vermeulen, Hannes Lans
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
DNA damage sensors DDB2 and XPC are fundamental factors to initiate global genome nucleotide excision repair and protect DNA from mutagenesis. Here the authors reveal that ubiquitin and TFIIH-stimulated DDB2 dissociation promotes DNA damage handover
Externí odkaz:
https://doaj.org/article/22a70086ef524db897815d6000e52c4e
Autor:
Cristina Ribeiro-Silva, Özge Z. Aydin, Raquel Mesquita-Ribeiro, Jana Slyskova, Angela Helfricht, Jurgen A. Marteijn, Jan H. J. Hoeijmakers, Hannes Lans, Wim Vermeulen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
SWI/SNF genes are commonly found to be mutated in different cancers. Here the authors report that the remodelers BRM and BRG1 are necessary for efficient nucleotide excision repair by promoting the expression of TFIIH subunit GTF2H1.
Externí odkaz:
https://doaj.org/article/eb220f4c08794f88ad5354ea35208f77
Autor:
Wim Vermeulen, Mariangela Sabatella, Cristina Ribeiro-Silva, Hannes Lans, Arjan F. Theil, Jurgen A. Marteijn, Angela Helfricht
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, 11(1):4868. Nature Publishing Group
Nature Communications
Nature Communications, 11(1):4868. Nature Publishing Group
DNA damage sensors DDB2 and XPC initiate global genome nucleotide excision repair (NER) to protect DNA from mutagenesis caused by helix-distorting lesions. XPC recognizes helical distortions by binding to unpaired ssDNA opposite DNA lesions. DDB2 bin
Autor:
Hyeongju Kim, Sophie Lenoir, Angela Helfricht, Taeyang Jung, Zhana K. Karneva, Yejin Lee, Wouter Beumer, Geert B. van der Horst, Herma Anthonijsz, Levi C.M. Buil, Frits van der Ham, Gerard J. Platenburg, Pasi Purhonen, Hans Hebert, Sandrine Humbert, Frédéric Saudou, Pontus Klein, Ji-Joon Song
Publikováno v:
JCI insight. 7(17)
Huntington's disease (HD) is a late-onset neurological disorder for which therapeutics are not available. Its key pathological mechanism involves the proteolysis of polyglutamine-expanded (polyQ-expanded) mutant huntingtin (mHTT), which generates N-t
Autor:
Peter E. Thijssen, Qiang Pan-Hammarström, Mélanie Rogier, Girish M. Shah, Gwendolynn Grootaers, Mirjam van der Burg, Anton J.L. de Groot, Angela Helfricht, Rianca Jak, Alfred C.O. Vertegaal, Monique M. van Ostaijen-ten Dam, Jun Wang, Vincent Heyer, Magdalena B. Rother, Likun Du, Hanna IJspeert, Jacques Moritz, Maarten J. D. van Tol, Haico van Attikum, Bernardo Reina-San-Martin, Pooja Rao, Sanami Takada, Rashmi G. Shah, Martijn S. Luijsterburg, Silvère M. van der Maarel, Chantal Stoepker
Publikováno v:
Journal of Experimental Medicine, 217(11). ROCKEFELLER UNIV PRESS
The Journal of experimental medicine, 217(11)
The Journal of Experimental Medicine
The Journal of experimental medicine, 217(11)
The Journal of Experimental Medicine
Mutations in ZBTB24 cause immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome. Helfricht et al. demonstrate that the loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination, proving a molecular basis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0193041240ab8d67e08c4936d5e79ad
https://hdl.handle.net/1887/3182619
https://hdl.handle.net/1887/3182619
Autor:
Laura K. Herzog, Klára Ács, Annika Pfeiffer, Martijn S. Luijsterburg, Claudia Böttcher, Florian A. Salomons, Angela Helfricht, Haico van Attikum, Nico P. Dantuma, Melania Minoia, Wouter W. Wiegant
Publikováno v:
The EMBO Journal. 36:1066-1083
The SUMO‐targeted ubiquitin ligase RNF4 functions at the crossroads of the SUMO and ubiquitin systems. Here, we report that the deubiquitylation enzyme (DUB) ataxin‐3 counteracts RNF4 activity during the DNA double‐strand break (DSB) response.
Autor:
Maxim A. X. Tollenaere, Audrey Furst, Alfred C.O. Vertegaal, Anton J.L. de Groot, Celine Bonhomme, Evi Soutoglou, Albert Pastink, Angela Helfricht, Martijn S. Luijsterburg, Pierre Caron, Haico van Attikum, Wouter W. Wiegant, Tibor Pankotai
Publikováno v:
Genes and Development
Genes and Development, Cold Spring Harbor Laboratory Press, 2019, 33 (11-12), pp.684-704. ⟨10.1101/gad.321943.118⟩
Genes and Development, 33(11-12), 684-704
Genes & Development, 33(11-12), 684-704. Cold Spring Harbor Laboratory Press
Genes and Development, Cold Spring Harbor Laboratory Press, 2019, 33 (11-12), pp.684-704. ⟨10.1101/gad.321943.118⟩
Genes and Development, 33(11-12), 684-704
Genes & Development, 33(11-12), 684-704. Cold Spring Harbor Laboratory Press
International audience; DNA double-strand breaks (DSBs) at RNA polymerase II (RNAPII) transcribed genes lead to inhibition of transcription. The DNA-dependent protein kinase (DNA-PK) complex plays a pivotal role in transcription inhibition at DSBs by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3fbab6f8cae3536a4ac95c637ef055
https://hal.archives-ouvertes.fr/hal-03476979/file/Genes&Dev_Caron_P.pdf
https://hal.archives-ouvertes.fr/hal-03476979/file/Genes&Dev_Caron_P.pdf
Autor:
Annika, Pfeiffer, Martijn S, Luijsterburg, Klara, Acs, Wouter W, Wiegant, Angela, Helfricht, Laura K, Herzog, Melania, Minoia, Claudia, Böttcher, Florian A, Salomons, Haico, van Attikum, Nico P, Dantuma
Publikováno v:
The EMBO Journal
The SUMO‐targeted ubiquitin ligase RNF4 functions at the crossroads of the SUMO and ubiquitin systems. Here, we report that the deubiquitylation enzyme (DUB) ataxin‐3 counteracts RNF4 activity during the DNA double‐strand break (DSB) response.