Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Angela H, DePace"'
Autor:
Francheska López-Rivera, Olivia K. Foster Rhoades, Ben J. Vincent, Edward C. G. Pym, Meghan D. J. Bragdon, Javier Estrada, Angela H. DePace, Zeba Wunderlich
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 12, Pp 4473-4482 (2020)
Externí odkaz:
https://doaj.org/article/7877909398334da2832ed1d253415d15
Autor:
Zeba Wunderlich, Charless C. Fowlkes, Kelly B. Eckenrode, Meghan D. J. Bragdon, Arash Abiri, Angela H. DePace
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 7, Pp 2171-2182 (2019)
Complex spatiotemporal gene expression patterns direct the development of the fertilized egg into an adult animal. Comparisons across species show that, in spite of changes in the underlying regulatory DNA sequence, developmental programs can be main
Externí odkaz:
https://doaj.org/article/9a3bccc7564c43f1bb7f313ed4835c39
Autor:
Md. Abul Hassan Samee, Tara Lydiard-Martin, Kelly M. Biette, Ben J. Vincent, Meghan D. Bragdon, Kelly B. Eckenrode, Zeba Wunderlich, Javier Estrada, Saurabh Sinha, Angela H. DePace
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 236-245 (2017)
Computational models of enhancer function generally assume that transcription factors (TFs) exert their regulatory effects independently, modeling an enhancer as a “bag of sites.” These models fail on endogenous loci that harbor multiple enhancer
Externí odkaz:
https://doaj.org/article/9483d46b30264d13827a992033d7aa7d
Autor:
Jeehae Park, Javier Estrada, Gemma Johnson, Ben J Vincent, Chiara Ricci-Tam, Meghan DJ Bragdon, Yekaterina Shulgina, Anna Cha, Zeba Wunderlich, Jeremy Gunawardena, Angela H DePace
Publikováno v:
eLife, Vol 8 (2019)
Developmental enhancers integrate graded concentrations of transcription factors (TFs) to create sharp gene expression boundaries. Here we examine the hunchback P2 (HbP2) enhancer which drives a sharp expression pattern in the Drosophila blastoderm e
Externí odkaz:
https://doaj.org/article/89490033d56044918068e1ebc5396b93
Autor:
Ben J Vincent, Max V Staller, Francheska Lopez-Rivera, Meghan D J Bragdon, Edward C G Pym, Kelly M Biette, Zeba Wunderlich, Timothy T Harden, Javier Estrada, Angela H DePace
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007644 (2018)
Hunchback is a bifunctional transcription factor that can activate and repress gene expression in Drosophila development. We investigated the regulatory DNA sequence features that control Hunchback function by perturbing enhancers for one of its targ
Externí odkaz:
https://doaj.org/article/5083d378a6224632ac9d51e671b59a36
Autor:
Zeba Wunderlich, Meghan D.J. Bragdon, Ben J. Vincent, Jonathan A. White, Javier Estrada, Angela H. DePace
Publikováno v:
Cell Reports, Vol 12, Iss 11, Pp 1740-1747 (2015)
Many developmental genes are controlled by shadow enhancers—pairs of enhancers that drive overlapping expression patterns. We hypothesized that compensatory evolution can maintain the total expression of a gene, while individual shadow enhancers di
Externí odkaz:
https://doaj.org/article/369d5b478d564c3eab11f13fed7bb429
Autor:
Rosa Martinez-Corral, Minhee Park, Kelly M. Biette, Dhana Friedrich, Clarissa Scholes, Ahmad S. Khalil, Jeremy Gunawardena, Angela H. DePace
Publikováno v:
Cell Systems. 14:324-339.e7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a859d62b3e2f068310c6f1b9c47e2ce9
https://doi.org/10.1016/j.cels.2023.02.003
https://doi.org/10.1016/j.cels.2023.02.003
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151740 (2016)
DNA-binding proteins control many fundamental biological processes such as transcription, recombination and replication. A major goal is to decipher the role that DNA sequence plays in orchestrating the binding and activity of such regulatory protein
Externí odkaz:
https://doaj.org/article/48bd1077048e45f1be4ef9694c9e0a09
Autor:
Zeba Wunderlich, Meghan D Bragdon, Kelly B Eckenrode, Tara Lydiard‐Martin, Sivanne Pearl‐Waserman, Angela H DePace
Publikováno v:
Molecular Systems Biology, Vol 8, Iss 1, Pp 1-15 (2012)
Abstract Gene expression patterns can diverge between species due to changes in a gene's regulatory DNA or changes in the proteins, e.g., transcription factors (TFs), that regulate the gene. We developed a modeling framework to uncover the sources of
Externí odkaz:
https://doaj.org/article/36e33656908e453b8800f14868479ae1
Autor:
Arash Abiri, Zeba Wunderlich, Angela H. DePace, Meghan D. J. Bragdon, Charless C. Fowlkes, Kelly B. Eckenrode
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 7, Pp 2171-2182 (2019)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
Complex spatiotemporal gene expression patterns direct the development of the fertilized egg into an adult animal. Comparisons across species show that, in spite of changes in the underlying regulatory DNA sequence, developmental programs can be main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69ca91e6c60ed346d0788f58daa147d
http://g3journal.org/lookup/doi/10.1534/g3.118.200953
http://g3journal.org/lookup/doi/10.1534/g3.118.200953