Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Angela Granelli-Piperno"'
Autor:
María Colmenares, Elena Sierra-Filardi, Ralph M. Steinman, Angela Granelli-Piperno, Elena Fernández-Ruiz, Angel L. Corbí, Rafael Samaniego, Ana Estecha, Paloma Sánchez-Mateos
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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DC-SIGN (dendritic cell-specific ICAM-3-grabbing non-integrin) is a myeloid pathogen-attachment factor C-type lectin which recognizes mannose- and fucose-containing oligosaccharide ligands on clinically relevant pathogens. Intracellular signaling ini
Autor:
Frederick P. Siegal, Ralph M. Steinman, Saurabh Mehandru, Mary Carrington, Angela Granelli Piperno, Leonia Bozzacco, Christine Trumpfheller, Martin Markowitz, Michel C. Nussenzweig
Publikováno v:
Proceedings of the National Academy of Sciences. 104:1289-1294
Optimal HIV vaccines should elicit CD8 + T cells specific for HIV proteins presented on MHC class I products, because these T cells contribute to host resistance to viruses. We had previously found that the targeting of antigen to dendritic cells (DC
Autor:
Romaine Stalder, Rafael Correa, Ralph M. Steinman, Vincent Piguet, Marjorie Pion, Angela Granelli-Piperno, Bastien Mangeat
Publikováno v:
The Journal of Experimental Medicine
HIV-1 infects immature dendritic cells (iDCs), but infection is inefficient compared with activated CD4+ T cells and only involves a small subset of iDCs. We analyzed whether this could be attributed to specific cellular restrictions during the viral
Autor:
Yaoxing Huang, Chae Gyu Park, Helena Soares, Bruno Moltedo, Angela Granelli-Piperno, Thomas M. Moran, Carolina B. López, Christine Trumpfheller, Michel C. Nussenzweig, Sarah J. Schlesinger, Ralph M. Steinman, Jennifer S. Finke
Publikováno v:
The Journal of Experimental Medicine
Current human immunodeficiency virus (HIV) vaccine approaches emphasize prime boost strategies comprising multiple doses of DNA vaccine and recombinant viral vectors. We are developing a protein-based approach that directly harnesses principles for g
Autor:
Angela Granelli-Piperno, Maggi Pack, Irina Shimeliovich, Christine Trumpfheller, Ralph M. Steinman
Publikováno v:
The Journal of Immunology. 176:991-998
The infection of cultured monocyte-derived dendritic cells (DCs) with HIV-1 involves CD4 and CCR5 receptors, while transmission to T cells is enhanced at least in part by the lectin DC-SIGN/CD209. In the present study, we studied BDCA-1+ myeloid DCs
Autor:
Michel C. Nussenzweig, Kang Liu, Angela Granelli-Piperno, Ralph M. Steinman, Laura Bonifaz, Jennifer S. Finke, Christine Trumpfheller
Publikováno v:
International Congress Series. 1285:19-27
To initiate immunity, dendritic cells (DCs) must capture antigens and respond to additional stimuli that induce their differentiation or maturation. Maturation allows DCs to switch from their steady state function of tolerance to the induction of dif
Autor:
Vincent Piguet, Chae Gyu Park, Thomas M. Moran, Alla Pritsker, Ralph M. Steinman, Jean-François Arrighi, Angela Granelli-Piperno, Christine Trumpfheller, Irina Shimeliovich, Maggi Pack
Publikováno v:
The Journal of Immunology. 175:4265-4273
The C-type lectin dendritic cell-specific ICAM 3-grabbing nonintegrin (DC-SIGN)/CD209 efficiently binds several pathogens, including HIV-1. DC-SIGN is expressed on monocyte-derived DCs in culture, and importantly, it is able to sequester HIV-1 within
Autor:
Angela Granelli-Piperno, Ralph M. Steinman, Frederick P. Siegal, Christine Trumpfheller, Angelika Golebiowska
Publikováno v:
Proceedings of the National Academy of Sciences. 101:7669-7674
Dendritic cells (DCs) undergo maturation during virus infection and thereby become potent stimulators of cell-mediated immunity. HIV-1 replicates in immature DCs, but we now find that infection is not accompanied by many components of maturation in e
Autor:
Zhiwei Chen, Jie Zhang, Angela Granelli-Piperno, George Lin, Stefan Pöhlmann, Frédéric Baribaud, Robert W. Doms, Charles M. Rice, Jane A. McKeating, George J. Leslie
Publikováno v:
Journal of Virology. 77:4070-4080
DC-SIGN and DC-SIGNR are two closely related membrane-associated C-type lectins that bind human immunodeficiency virus (HIV) envelope glycoprotein with high affinity. Binding of HIV to cells expressing DC-SIGN or DC-SIGNR can enhance the efficiency o
Autor:
Wellington Sun, Michael A. Eller, Kovit Pattanapanyasat, S Sarasombath, Angela Granelli-Piperno, Jennifer S. Finke, Timothy Burgess, Deborah L. Birx, Boonrat Tassaneetrithep, Ralph M. Steinman, Sarah J. Schlesinger, Mary A. Marovich, Christine Trumpfheller
Publikováno v:
The Journal of Experimental Medicine
Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin,