cGAS-dependent proinflammatory and immune homeostatic effects of the microtubule-targeting agent paclitaxel

Autor: Angela Flavia Serpico, Caterina Pisauro, Domenico Grieco

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Taxanes are Microtubule-Targeting Agents (MTAs) that exert potent anticancer activity by directly killing cancer cells. However, recent evidence suggests that they may also stimulate inflammation and anticancer adaptive immunity and that these action

Externí odkaz: https://doaj.org/article/106bc4c27ade4ccf9fd1ed2755463c60

Recent advances in understanding the role of Cdk1 in the Spindle Assembly Checkpoint [version 1; peer review: 2 approved]

Autor: Angela Flavia Serpico, Domenico Grieco

Publikováno v: F1000Research, Vol 9 (2020)

The goal of mitosis is to form two daughter cells each containing one copy of each mother cell chromosome, replicated in the previous S phase. To achieve this, sister chromatids held together back-to-back at their primary constriction, the centromere

Externí odkaz: https://doaj.org/article/57d2c1665273493380f781c8f937bf9c

On the assembly of the mitotic spindle, bistability and hysteresis

Autor: Angela Flavia Serpico, Caterina Pisauro, Domenico Grieco

During cell division, the transition from interphase to mitosis is dictated by activation of the cyclin B-cdk1 (Cdk1) complex, master mitotic kinase. During interphase, Cdk1 accumulates in an inactive state (pre-Cdk1). When Cdk1 overcomes a certain t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f221166f6306088023a491b3427a9e
https://hdl.handle.net/11588/916066

Exploiting immune-dependent effects of microtubule-targeting agents to improve efficacy and tolerability of cancer treatment

Autor: Domenico Grieco, Roberta Visconti, Angela Flavia Serpico

Publikováno v: Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 5, Pp 1-7 (2020)

Microtubule-targeting agents (MTAs), like taxanes and vinca alkaloids, are tubulin-binding drugs that are very effective in the treatment of various types of cancers. In cell cultures, these drugs appear to affect assembly of the mitotic spindle and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f92926e6e0fb40c6d7ff2e2567342f
https://doi.org/10.1038/s41419-020-2567-0

Evidence that PP2A activity is dispensable for spindle assembly checkpoint-dependent control of Cdk1

Autor: Mario Scaraglio, Rosa Della Monica, Roberta Visconti, Domenico Grieco, Nando Cervone, Cinzia Vetrei, Angela Flavia Serpico

Publikováno v: Oncotarget 9 (2018): 7312–7321. doi:10.18632/oncotarget.23329
info:cnr-pdr/source/autori:Cervone N.; Monica R.D.; Serpico A.F.; Vetrei C.; Scaraglio M.; Visconti R.; Grieco D./titolo:Evidence that PP2A activity is dispensable for spindle assembly checkpoint-dependent control of Cdk1/doi:10.18632%2Foncotarget.23329/rivista:Oncotarget/anno:2018/pagina_da:7312/pagina_a:7321/intervallo_pagine:7312–7321/volume:9
Oncotarget

Progression through mitosis, the cell cycle phase deputed to segregate replicated chromosomes, is granted by a protein phosphorylation wave that follows an activation-inactivation cycle of cyclin B-dependent kinase (Cdk) 1, the major mitosis-promotin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fca52ade486c16bfa2fa2f57f9d56ee
https://doi.org/10.18632/oncotarget.23329